What clinical and laboratory parameters determine significant intra abdominal pathology for patients assessed in hospital with acute abdominal pain?
© Abbas et al; licensee BioMed Central Ltd. 2007
Received: 30 May 2007
Accepted: 25 September 2007
Published: 25 September 2007
Abdominal pain is a common cause for emergency admission. While some patients have serious abdominal pathology, a significant group of those patients have no specific cause for the pain. This study was conducted to identify those who have non-specific abdominal pain who can be either admitted short term for observation or reassured and discharged for outpatient management.
Patients and methods
A prospective documentation of clinical and laboratory data was obtained on a consecutive cohort of 286 patients who were admitted to a surgical unit over a nine month period with symptoms of abdominal pain regarded severe enough for full assessment in the casualty department and admission to a surgical ward. The patients were followed until a definite diagnosis was made or the patient's condition and abdominal pain improved and the patient discharged. The hospital where the study took place is a small peripheral general hospital draining a population of 120,000 people in a rural area in New Zealand.
There were 286 admissions to the emergency department. Logistic regression multivariate statistical analysis showed that guarding raised white cells count, tachycardia and vomiting were the only variables associated with significant pathology.
Patients with no vomiting, no guarding, who have normal pulse rates and normal white cell counts are unlikely to have significant pathology requiring further active intervention either medical or surgical.
Abdominal pain is very common presentation to emergency department. It is vital that the physician has an understanding and be familiar with the presentations of common diseases that cause abdominal pain [1, 2]. Patients with acute abdominal pain are a heterogeneous group that consumes a great deal of a surgical department's resources. To streamline efficiency and provide maximum cost effectiveness it would be of benefit to identify clinical and laboratory parameters in patients admitted with acute abdominal pain that would indicate no significant intra abdominal pathology and thereby encourage early discharge back to the community [3, 4].
Women of childbearing age commonly present with right iliac fossa pain, most of them do not have appendicitis . Those who do not have the classical features of appendicitis with no evidence of peritonism on examination can be safely managed by active observation or diagnostic laparoscopy [4, 5]. This study was designed to identify the clinical and laboratory red flags. Recognizing these red flags in the history and physical examination and the initial imaging and laboratory findings helps to determine which patients may have a serious underlying disease process, and therefore warrant more expedited evaluation and treatment.
Patients and methods
Patients assessed at the emergency department at Rotorua Public Hospital with acute abdominal pain requiring admission to the surgical unit were enrolled in the prospective study.
Patients were examined by the admitting surgical team after taking a thorough history, Relevant points in the history included the patient's gender, duration of pain, site of pain, character of pain, fever, loss of appetite, change in bowel habit, vomiting, abdominal distension and urinary or genital symptoms.
Factors in the clinical examination that were considered of significant contribution to the final diagnosis included temperature, tachycardia, and abdominal tenderness and localized guarding.
Data was collected prospectively on an electronic database. Patients were followed up with further investigations that included ultrasound scan, CT scan and diagnostic laparotomy as was clinically indicated to ascertain the final diagnosis. All patients were admitted for observation or surgery if indicated.
Non-specific abdominal pain was defined as an abdominal pain in right iliac or hypogastric area lasting more than 6 hours and less than 8 days, without fever, leukocytosis, or obvious peritoneal signs and uncertain diagnosis after physical examination and baseline investigations including abdominal sonography; provide they have totally settled or underwent diagnostic laparoscopy that proved to be normal.
Analysis was performed to evaluate the relative contribution and specificity of each individual factor to a definitive final diagnosis that led to identification those who had no definitive diagnosis. The data analyzed using SPSS® version 10.5. Univariate analysis was performed using simple linear regression; multivariate analysis was performed using logistic regression analysis.
Surgical causes of pain
Number of patients
Cholecystitis (normal liver function test)
Probable Sub-acute small bowel obstruction (minimal X rays findings)
Peptic ulcer disease
Pancreatitis with normal amylase
Non surgical causes of pain.
Method of diagnosis
Acute pelvic inflammatory disease
Rupture ovarian follicle
Urinary tract infection
Midstream urine examination and culture
Clinical evidence (diarrhea and vomiting)
Clostridium Difficile colitis
Character of the pain
Lack of appetite
Patient in distress
Altered bowel habit
Location of the pain
Character of the pain
Altered bowel habit
Lack of appetite
The current study shows that patients who present with abdominal pain with no vomiting, guarding or raised white cell count are unlikely to have significant intra abdominal pathology and therefore can be considered for early discharge back to the community. Abnormal liver function test was helpful to point out the possibility of biliary colic, so was microscopic hematuria that may reflect urinary tract pathology.
Complaints of acute abdominal pain are common emergency department presentations. Many of these conditions prove to be benign and self-limiting illness, which has no clear explanation. Tenderness and peritonism in the right iliac fossa are not specific for appendicitis but may help to narrow the differential diagnosis in patients with right iliac fossa pain [6, 7]. However high WBC counts and left shift are strongly associated with appendicitis in children aged 1 to 19 years indeed for children older than 4 years with lower abdominal pain; the most common diagnosis in the setting of an elevated WBC count is acute appendicitis .
In females of childbearing age, the presence or absence of bilateral tenderness pain migration and vomiting may help to differentiate acute appendicitis from acute pelvic inflammatory disease  where patients tend to have raised white cells count and demonstrate signs of peritonism, which can make the differentiation between the two diagnoses on clinical grounds difficult. Mesenteric adenitis is very difficult to diagnose clinically and commonly patients undergo treatment for presumed appendicitis [10–12].
Imaging such as ultrasound  is helpful for detection of the cause of lower abdominal pain; in clinical centers where CT scan is routinely performed it reduces the rate of both negative appendicectomy and perforated appendicitis, whoever CT scanning has significant radiation dose for children and young adults [9, 14] and its not always practical or available. On the other hand elderly patients can have atypical presentations; vascular events are more common in this population, and a wide differential diagnosis needs to be considered .
Early diagnostic laparoscopy and treatment results in accurate, prompt, and efficient management of acute abdominal pain. This technique reduces the rate of unnecessary laparotomy and right iliac fossa gridiron incisions and increases the diagnostic accuracy in these patients; however this approach is expensive with significant use of the resources and potential morbidity . Diagnostic laparoscopy also avoids extensive preoperative investigations, averts delays in operative management . Morino et al assessed the role of diagnostic laparoscopy and concluded that laparoscopy compared with clinical observation, early laparoscopy did not show a clear benefit in women with non-specific abdominal pain. They reported higher number of diagnosis and a shorter hospital stay in the laparoscopy group [17, 18]. In another study patients who have no evidence of guarding, normal temperature, and normal white cells count were observed; a practice that is proven to reduce the rate of negative appendicectomy . Non-specific abdominal pain is the most common diagnosis in patients admitted with acute abdominal pain (25–35% of all patients), and of those patients only a quarter needs surgical intervention [2, 19]. Clinical scores that were developed to recognize acute appendicitis  are useful but those score could only be used with clinical judgment, if there is any suspicion of serious pathology the patient should undergo a diagnostic laparoscopy.
The current study shows the likely groups of patients with non-specific abdominal pain are those with normal white cell count, no history of vomiting and absent signs of peritoneal irritation with normal heart rate. Patients who fulfill those findings are suitable for early discharge, which may help to reduce the health care cost for those patients. All patients admitted to emergency department with abdominal pain should be referred for surgical opinion and the diagnosis of nonspecific abdominal pain should only be made after thorough assessment, definite pathology excluded and the patient does not return with the same complaint.
(Written consent for publication was obtained from the patient or their relative.)
- Laurell H, Hansson LE, Gunnarsson U: Diagnostic pitfalls and accuracy of diagnosis in acute abdominal pain. Scand J Gastroenterol. 2006, 41 (10): 1126-31. 10.1080/00365520600587485.View ArticlePubMed
- Flasar MH, Goldberg E: Acute abdominal pain. Med Clin North Am. 2006, 90: 481-503. 10.1016/j.mcna.2005.11.005.View ArticlePubMed
- Bjerkeset T, Havik S, Aune KE, Rosseland A: Acute abdominal pain as cause of hospitalisation. Tidsskr Nor Laegeforen. 2006, 8 (126): 1602-1604.
- Rennie AT, Tytherleigh MG, Theodoroupolou K, Farouk R: A prospective audit of 300 consecutive young women with an acute presentation of right iliac fossa pain. Ann R Coll Surg Engl. 2006, 88: 140-3. 10.1308/003588406X94887.PubMed CentralView ArticlePubMed
- Golash V, Willson PD: Early laparoscopy as a routine procedure in the management of acute abdominal pain: a review of 1,320 patients. Surg Endosc. 2005, 19 (7): 882-5. 10.1007/s00464-004-8866-1.View ArticlePubMed
- Groselj-Grenc M, Repse S, Dolenc-Strazar Z, Hojker S, Derganc M: Interleukin-6 and lipopolysaccharide-binding protein in acute appendicitis in children. Scand J Clin Lab Invest. 2007, 67 (2): 197-206. 10.1080/00365510601010397.View ArticlePubMed
- Sack U, Biereder B, Elouahidi T, Bauer K, Keller T, Trobs RB: Diagnostic value of blood inflammatory markers for detection of acute appendicitis in children. BMC Surg. 2006, 28 (6): 15-15. 10.1186/1471-2482-6-15.View Article
- Morishita K, Gushimiyagi M, Hashiguchi M, Stein GH, Tokuda Y: Clinical prediction rule to distinguish pelvic inflammatory disease from acute appendicitis in women of childbearing age. Am J Emerg Med. 2007, 25 (2): 152-7. 10.1016/j.ajem.2006.06.013.View ArticlePubMed
- Lee CC, Golub R, Singer AJ, Cantu R, Levinson H: Routine versus selective abdominal computed tomography scan in the evaluation of right lower quadrant pain: a randomized controlled trial. Acad Emerg Med. 2007, 14 (2): 117-22. 10.1197/j.aem.2006.08.007.View ArticlePubMed
- Likitnukul S, Wongsawat J, Nunthapisud P: Appendicitis-like syndrome owing to mesenteric adenitis caused by Salmonella typhi. Ann Trop Paediatr. 2002, 22 (1): 97-9. 10.1179/027249302125000247.View ArticlePubMed
- Prince RL: Evidence for an aetiological role for adenovirus type 7 in the mesenteric adenitis syndrome. Med J Aust. 2 (2): 56-7. 1979 Jul 28
- Hawthorn IE: Abdominal pain as a cause of acute admission to hospital. J R Coll Surg Edinb. 1992, 37 (6): 389-93.PubMed
- Douglas Charles, Macpherson Neil, Davidson Patricia, Gani Jonathon: Randomised controlled trial of ultrasonography in diagnosis of acute appendicitis, incorporating the Alvarado score. BMJ. 321: 919-22. 10.1136/bmj.321.7266.919. 2000 Oct 14
- Ganguli S, Raptopoulos V, Komlos F, Siewert B, Kruskal JB: Right lower quadrant pain: value of the nonvisualized appendix in patients at multidetector CT. Radiology. 2006, 241 (1): 175-80. 10.1148/radiol.2411050191.View ArticlePubMed
- Martinez JP, Mattu A: Abdominal pain in the elderly. Emerg Med Clin North Am. 2006, 24 (2): 371-88. 10.1016/j.emc.2006.01.010. vii. ReviewView ArticlePubMed
- Kirshtein B, Roy-Shapira A, Lantsberg L, Mandel S, Avinoach E, Mizrahi S: The use of laparoscopy in abdominal emergencies. Surg Endosc. 2003, 17 (7): 1118-24. 10.1007/s00464-002-9114-1.View ArticlePubMed
- Morino M, Pellegrino L, Castagna E, Farinella E, Mao P: Acute nonspecific abdominal pain: A randomized, controlled trial comparing early laparoscopy versus clinical observation. Ann Surg. 2006, 244 (6): 881-6. 10.1097/01.sla.0000246886.80424.ad.PubMed CentralView ArticlePubMed
- Arfa N, Gharbi L, Marsaoui L, Ben Rhouma S, Farhati S, Bougamra S, Mannai S, Ghariani B, Mestiri H, Khalfallah MT: Value of admission for observation in the management of acute abdominal right iliac fossa pain. Prospective study of 205 cases. Presse Med. 2006, 35 (3 Pt 1): 393-8.View ArticlePubMed
- Newton E, Mandavia S: Surgical complications of selected gastrointestinal emergencies: pitfalls in management of the acute abdomen. Emerg Med Clin North Am. 2003, 21 (4): 873-907. 10.1016/S0733-8627(03)00087-7. viii. ReviewView ArticlePubMed
- Sooriakumaran P, Lovell D, Brown R: A comparison of clinical judgment Vs the modified Alvarado score in acute appendicitis. Int J Surg. 2005, 3: 49-52. 10.1016/j.ijsu.2005.03.009.View ArticlePubMed
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