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Table 2 Ranking of twelve best biomarkers according to Youden index

From: Diagnostic accuracy of biomarkers to detect acute mesenteric ischaemia in adult patients: a systematic review and meta-analysis

 

Any stage

Transmural

Overall

Biomarker

Youden index

Biomarker

Youden index

Biomarker

Youden index

1

IMA

0.85

I-FABP urine

0.77

IMA *

0.85

2

IL-6

0.82

IL-6

0.73

IL-6 #

0.79

3

PCT

0.68

D-dimer

0.71

I-FABP urine

0.67

4

I-FABP serum

0.63

I-FABP serum

0.68

PCT

0.67

5

alpha-GST

0.61

PCT

0.62

I-FABP serum

0.64

6

CRP

0.60

CRP

0.56

alpha-GST *

0.61

7

I-FABP urine

0.58

L-lactate

0.50

D-dimer

0.60

8

D-dimer

0.57

D-lactate

0.38

CRP

0.58

9

NLR

0.54

WBC

0.37

D-lactate

0.55

10

D-lactate

0.50

LDH

0.34

NLR

0.47

11

Citrulline

0.46

PLR

0.31

Citrulline *

0.46

12

L-lactate

0.42

pH

0.18

L-lactate

0.44

  1. Alpha-GST—alpha glutathione S transferase (alpha-GST); CRP—C-reactive protein; I-FABP—intestinal fatty acid-binding protein; IL-6—interleukin 6; IMA—ischaemia-modified albumin; LDH—lactate dehydrogenase; NLR—neutrophil–lymphocyte ratio; PCT—procalcitonin; PLR—platelet–lymphocyte ratio; WBC—white blood cell count
  2. Any stage—studies assessing different stages of AMI, including but not limited to non-transmural and transmural; Transmural—studies assessing transmural AMI, with control group including non-transmural AMI; Overall—all studies pooled independent of stage and type of AMI
  3. *No study on transmural acute mesenteric ischaemia of any type
  4. #No study on non-occlusive mesenteric ischaemia
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World Journal of Emergency Surgery

ISSN: 1749-7922