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Table 1 Clinical findings in three case reports

From: Necrotizing fasciitis: literature review of contemporary strategies for diagnosing and management with three case reports: torso, abdominal wall, upper and lower limbs

Clinical findings First case: 69 yr/M
DM-type II, with NF of CW, shoulder, and arm
Secound case: 63 yr/M
DM-type I, paraplegic with Fournier's gangrene
Third case: 56 yr/M with inquinal hernia repair and NF of AW and RP space
Preexisting medical conditions DM type-II, hypertension, alcohol abuse, heart disease, peripheral vascular and pulmonary disease, malnutrition, chronic wound (pressure sores, diabetes and venous ulcer) DM type I, hypertension, paraplegia, obesity, heart disease, peripheral. vascular and pulmonary disease, immune deficiency, pressure sores hypertension, alcohol abuse,
peripheral vascular disease
Physical findings swelling, erythema, redness, induration, crepitus, pain, fever, warm skin, blisters, skin discoloration, numbness, soft tissue emphysema, confusion, weakness, skin sloughing/necrosis induration, pain, crepitus, fever, warm skin, blisters, skin discoloration, soft tissue emphysema, paraplegia confusion, numbness swelling, erythema, redness, induration, crepitus, pain, fever, warm skin, blisters, soft tissue emphysema, confusion, weakness, skin sloughing/necrosis
Vital sings and laboratory valves SIRS and signs of systemic toxicity, positive LRINEC scour system. SIRS and signs of systemic toxicity, positive LRINEC scour system. SIRS and signs of systemic toxicity, positive LRINEC scour system
Source of infection skin abscess/furunculosis perineal abscesses, Fournier's gangrene inguinal hernia repair, bowel perforation.
Microbiology findings aerobes and anaerobes aerobes and anaerobes aerobes and anaerobes
Treatment modalities:    
primary debridement yes yes yes
operative intervals (days):    
   admission to first debridment 3 hours 6 hours 72 hours
   first to last debridment 2 5 5
   first debridement. to final closure 14 days 12 days 12 days
   days to granulation tissue formation 7 days 10 days 10 days
   hydrofiber dressing yes yes yes
Adjuvant HBO therapy yes yes yes
HBO sessions 4 sessions 11 sessions 11 sessions
Combination of antibiotics used Penincillin G, Clindamycin, Imipenem, Teicoplanin Penicilin G, Gentamycin, Clyndamicin Penicilin G, Gentamycin, Clyndamicin, Metronidazol
Outpatient treatment oral anti-diabetic drugs, antihypertensive drugs, cardiotonics Insulin therapy, antihypertensive drugs, cardiotonics, different types of peroral antibiotics for 2 months antihypertensive drugs, cardiotonics,
ICU therapy dominantly mechanical ventilation, nutritional support, whole blood, fresh frozen plasma, erythrocyte concentrate, combination of 4 antibiotics (AB) which depending on wound culture or blood culture (administered for 10 days and target AB for 18 days) dominantly dialysis, nutritional support, blood whole blood, fresh frozen plasma, erythrocyte concentrate combination of 3 antibiotics which depending on wound culture or blood culture (administered for 10 days and target AB for 11 days) dominantly nutritional support whole blood, fresh frozen plasma, erythrocyte concentrate combination of 4 antibiotics which depending on wound culture or blood culture (administered for 14 days)
Main complications delay in diagnosis and first debridement, inadequate serial debridement's, bacteriemia, sepsis, wound infection (MRSA), pressure sores, skin graft lysis delay in diagnosis and first debridement, inadequate serial debridement, bacteriemia, sepsis, MODS, wound infection-MRSA, skin graft lysis, diverting colostomy, pressure sores delay in diagnosis and first debridement, inadequate serial debridement, bowel perforation, bacteriemia, sepsis, secondary peritonitis, MODS, wound infection(MRSA), diverting colostomy, pressure sores
Reconstruction skin grafts (SG), local flaps, topical negative pressure therapy with SG skin grafts, local flaps, topical negative pressure therapy with SG, component separation technique with biological mesh direct sutures, local flaps, component separation technique with biological mesh