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Table 3 Risk factors for development of NSTI and the LRINEC scoring system for prediction of NSTI

From: Necrotizing fasciitis: literature review of contemporary strategies for diagnosing and management with three case reports: torso, abdominal wall, upper and lower limbs

Risk factors   LRINEC scoring system  
  Variable Values Score
Preexisting conditions C-reactive protein ≤150 mg/L 0
diabetes, immunosupression   > 150 mg/L 4
alcoholism, peripheral vascular disease, IV drug abuse, hypertension, corticosteroids, HIV, age < 50 years, GI malignance, malnutrition, major trauma, surgery, perforated viscera, chronic live disease, chronic renal insufficiency, obesity White blood cell count < 15 per mm2 0
   15-25 per mm2 1
   > 25 per mm2 2
  Hemoglobin ≤13,5 g/dL 0
   11-13,5 g/dL 1
   < 11 g/dL 2
  Sodium ≥ 135 mmol/L 0
   > 135 mmol/L 2
Existing illness and injuries Creatinine < 141 μmol/L 0
Varicella with bacterial superinfection, fractures, liposuction, seawater-seafood, surgery, spider bite and other bites, Cesarean section, burns   > 141 μmol/≤L 2
  Glucose ≤10 mmol/L 0
   > 10 mmol/L 1
  1. NSTI-necrotizing soft tissue infection; GI-gastrointestinal; HIV-human immunodeficiency virus;
  2. LRINEC-Laboratory Risk Indicator for Necrotizing Fasciitis: A score of ≥ 6 is suspicious for NSTI, a score of ≥8 is highly predictive of NSTI