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Table 2 Characteristics of the randomized controlled trials on IAP, IAH, and ACS

From: Successful interventional management of abdominal compartment syndrome caused by blunt liver injury with hemorrhagic diathesis

Author N Study population Intervention Control Main conclusion
Celik[15] 100 Patients undergoing elective 5 different IAP levels; 8, 10, NA No effect of IAP levels on gastric
   Laparoscopic cholecystectomy 12, 14, and 16 mm Hg   intramucosal pH
Basgul[16] 22 Patients undergoing elective laparoscopic cholecystectomy Low IAP level (10 mm Hg) High IAP level (14Y15 mm Hg) Less depression of immune function (expressed as interleukin 2 and 6) in the low IAP group
O’Mara[17] 31 Burn patients (>25% TBS with inhalation injury or >40% TBS without) Plasma resuscitation Crystalloid resuscitation Less increase in IAP and less volume requirement in plasma-resuscitated patients
Sun[18] 110 Severe acute pancreatitis patients Routine conservative treatment combined with indwelling catheter drainage Routine conservative treatment Lower mortality, lower APACHE II scores after 5 d and shorter hospitalization times in intervention group
Bee[19] 51 Patients undergoing emergency laparotomy requiring temporary abdominal closure Vacuum-assisted closure Mesh closure No signification differences in delayed fascial closure or fistula rate
Karagulle[20] 45 Patients undergoing elective laparoscopic cholecystectomy 3 different IAP levels; 8, 12, and 15 mm Hg NA Similar effects on pulmonary function test results
Zhang[21] 80 Severe acute pancreatitis patients Da-Cheng-Qi decoction enema and sodium sulphate orally Normal saline enema Lower IAP levels in intervention group
Ekici[22] 52 Patients undergoing elective laparoscopic cholecystectomy Low IAP level (7 mm Hg) High IAP level (15 mm Hg) More pronounced effect of high IAP on QT dispersion
Joshipura[23] 26 Patients undergoing elective laparoscopic cholecystectomy Low IAP level (8 mm Hg) High IAP level (12 mm Hg) Decrease in postoperative pain and hospital stay, and preservation of lung function in low pressure level group
Mao[24] 76 Severe acute pancreatitis patients Controlled fluid resuscitation Rapid fluid resuscitation Lower incidence of ACS in controlled fluid resuscitation group (i.a.)
Yang[25] 120 Severe acute pancreatitis patients Colloid plus crystalloid resuscitation Crystalloid resuscitation Decline of IAP was significant higher in crystalloid plus colloid group
Celik[26] 60 Patients undergoing elective laparoscopic cholecystectomy 3 different IAP levels; 8, 12 and 14 mm Hg NA No effect of IAP level on postoperative pain
Chen[27] 60 ICU patients with multiorgan failure Tongfu Granule Placebo Decreased IAP in intervention group
    (Traditional Chinese medicines)  
Agarwal[28] 190 Patients undergoing emergency laparotomy Reinforced tension line sutures Continuous suturing No difference in IAP but increased incidence of fascial dehiscence in continuous suture group
Du[29] 41 Severe acute pancreatitis patients Hydroxyethyl starch resuscitation Ringer’s lactate resuscitation Lower incidence of IAH and reduced use of mechanical ventilation in intervention group
Topal[30] 60 Patients undergoing elective laparoscopic cholecystectomy 3 different IAP levels; 10, 13, and 16 mm Hg NA No differences on thromboelastography
  1. N: number of patients, APACHE: Acute Physiology And Chronic Health Evaluation, NA: not applicable/available; TBS: Total body surface area, IAP: intra-abdominal pressure, IAH: intra-abdominal hypertension, ACS: abdominal compartment syndrome.