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Table 3 Warfarin anticoagulation reversal agents prescribed

From: Comparison of 3-Factor Prothrombin Complex Concentrate and Low-Dose Recombinant Factor VIIa for Warfarin Reversal

 

PCC3 (n = 74)

LD rFVIIa (n = 32)

p

Initial coagulation factor dose

   

Total Dose (units)*

1540 [1429-1978]

1000 [1000-1000]

NA

Weight-based Dose (units/kg)*

19.9 [18.6-20.8]

11.5 [10.1-15.0]

NA

Other reversal agents administered

Vit K, n (%)

57 (77.0%)

22 (68.8%)

0.37

FFP, n (%)

49 (66.2%)

21 (65.6%)

0.95

FFP units*

2 [0-4]

2 [0-4]

0.75

Total cost for reversal agents:

Coagulation factor (USD)*:

1116.50 [963-1718]

1230 [1170-1360]

0.26

FFP(USD)*:

393 [0-496]

393 [0-496]

0.65

Total(USD)*:

1526 [1299-2047]

1609.50 [1360-1756]

<0.05

  1. *Data as median [IQR].
  2. PCC3, 3 factor prothrombin complex concentrate; LDrFVIIa, low dose recombinant factor VII activated; kg, kilograms; FFP, fresh frozen plasma; vit K, vitamin K, USD, United States Dollars).