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Table 3 Antimicrobial regimens suggested for acute calculous cholecystitis

From: 2016 WSES guidelines on acute calculous cholecystitis

Community acquired Health-care associated
1) Beta-lactam/beta-lactamase inhibitor combinations based regimens
AMOXICILLIN/CLAVULANATE (in stable patients)
TICARCILLIN/CLAVULANATE (in stable patients)
PIPERACILLIN/TAZOBACTAM (in unstable patients)
2) Cephalosporins based regimens
CEFTRIAZONE + METRANIDAZOLE (in stable patients)
CEFEPIME + METRANIDAZOLE (in stable patients)
CEFTAZIDIME + METRANIDAZOLE (in stable patients)
CEFOZOPRAM + METRANIDAZOLE (in stable patients)
3) Carbapenem based regimens
ERTAPENEM (in stable patients)
IMIPENEM/CILASTATIN (only in unstable patients)
MEROPENEM (only in unstable patients)
DORIPENEM (only in unstable patients)
4) Fluoroquinolone based regimens (In case of allergy to beta-lactams)
CIPROFLOXACIN + METRONIDAZOLE (only in stable patients)
LEVOFLOXACIN + METRONIDAZOLE (only in stable patients)
MOXIFLOXACIN (only in stable patients)
5) Glycylcycline based regimen
TIGECYCLINE (in stable patients if risk factors for ESBLs)
IMIPENEM/CILASTATIN +/- TEICOPLANIN (only in unstable patients)
MEROPENEM +/- TEICOPLANIN (only in unstable patients)
DORIPENEM +/- TEICOPLANIN (only in unstable patients)