Table 3 Antimicrobial regimens suggested for acute calculous cholecystitis

1) Beta-lactam/beta-lactamase inhibitor combinations based regimens

AMOXICILLIN/CLAVULANATE (in stable patients)

TICARCILLIN/CLAVULANATE (in stable patients)

PIPERACILLIN/TAZOBACTAM (in unstable patients)

2) Cephalosporins based regimens

CEFTRIAZONE + METRANIDAZOLE (in stable patients)

CEFEPIME + METRANIDAZOLE (in stable patients)

CEFTAZIDIME + METRANIDAZOLE (in stable patients)

CEFOZOPRAM + METRANIDAZOLE (in stable patients)

3) Carbapenem based regimens

ERTAPENEM (in stable patients)

IMIPENEM/CILASTATIN (only in unstable patients)

MEROPENEM (only in unstable patients)

DORIPENEM (only in unstable patients)

4) Fluoroquinolone based regimens (In case of allergy to beta-lactams)

CIPROFLOXACIN + METRONIDAZOLE (only in stable patients)

LEVOFLOXACIN + METRONIDAZOLE (only in stable patients)

MOXIFLOXACIN (only in stable patients)

5) Glycylcycline based regimen

TIGECYCLINE (in stable patients if risk factors for ESBLs)

TIGECYCLINE + PIPERACILLIN/TAZOBACTAM (in stable patients)

IMIPENEM/CILASTATIN +/- TEICOPLANIN (only in unstable patients)

MEROPENEM +/- TEICOPLANIN (only in unstable patients)

DORIPENEM +/- TEICOPLANIN (only in unstable patients)