Table 2 Recommended intravenous doses of the most commonly used antibiotics for patients with intra-abdominal infections and normal renal function (CrCl > 90 mL/min)
Intravenous Antibiotic | Intravenous dosing recommendation for patients with normal renal function*(CrCl > 90 mL/min) |
|---|---|
Penicillins/ Beta-lactamase Inhibitors | |
Amoxicillin/clavulanate | 1.2 g 8-hourly |
Ampicillin/Sulbactam | 3 g 6-hourly |
Piperacillin/tazobactam | 4.5 g 6- 8-hourly or 3.375 g 6-hourly |
Carbapenems | |
Ertapenem | 1 g 24-hourly |
Imipenem/cilastatin | 0.5 g 6-hourly (or1 g 8-hourly) |
Meropenem | 1 g 8-hourly |
Fluoroquinolones | |
Ciprofloxacin | 400 mg 8–12 hourly |
Levofloxacin | 750 mg 24-hourly |
Moxifloxacin | 400 mg 24-hourly |
Cephalosporins | |
Ceftriaxone | 1–2 g 24-hourly |
Ceftazidime | 2 g 8-hourly |
Cefepime | 1–2 g 8 hourly |
Ceftolozane/tazobactam | 1.5 g 8-hourly |
Ceftazidime/avibactam | 2.5 g 8-hourly |
Glycylcyclines | |
Tigecycline | 100 mg initial dose, then 50 mg 12-hourly |
Aminoglycosides | |
Amikacin | 15–20 mg/kg 24-hourly |
Gentamicin | 5–7 mg/kg 24-hourly |
5-nitroimidazole | |
Metronidazole | 500 mg 6–8 hourly |
Glycopeptides | |
Teicoplanin | 12 mg/kg 12-hourly times 3 loading dose then 12 mg/kg 24-hourly |
Vancomycin | 15–20 mg/kg/dose 8–12 hourly; in critically ill patients 25–30 mg/kg loading dose |
Oxazolidinonees | |
Linezolid | 600 mg 12 hourly |
Polymyxins | |
Colistin | US: 2.5 to 5 mg/kg CBA 8–12 hourly Europe: 9 million IU 8–12 hourly as a slow intravenous; in critically ill patients 9 million IU loading dose as a slow intravenous infusion |