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Table 2 Recommended intravenous doses of the most commonly used antibiotics for patients with intra-abdominal infections and normal renal function (CrCl > 90 mL/min)

From: Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Intravenous Antibiotic Intravenous dosing recommendation for patients with normal renal function*(CrCl > 90 mL/min)
Penicillins/ Beta-lactamase Inhibitors
 Amoxicillin/clavulanate 1.2 g 8-hourly
 Ampicillin/Sulbactam 3 g 6-hourly
 Piperacillin/tazobactam 4.5 g 6- 8-hourly or 3.375 g 6-hourly
Carbapenems
 Ertapenem 1 g 24-hourly
 Imipenem/cilastatin 0.5 g 6-hourly (or1 g 8-hourly)
 Meropenem 1 g 8-hourly
Fluoroquinolones
 Ciprofloxacin 400 mg 8–12 hourly
 Levofloxacin 750 mg 24-hourly
 Moxifloxacin 400 mg 24-hourly
Cephalosporins
 Ceftriaxone 1–2 g 24-hourly
 Ceftazidime 2 g 8-hourly
 Cefepime 1–2 g 8 hourly
 Ceftolozane/tazobactam 1.5 g 8-hourly
 Ceftazidime/avibactam 2.5 g 8-hourly
Glycylcyclines
 Tigecycline 100 mg initial dose, then 50 mg 12-hourly
Aminoglycosides
 Amikacin 15–20 mg/kg 24-hourly
 Gentamicin 5–7 mg/kg 24-hourly
5-nitroimidazole
 Metronidazole 500 mg 6–8 hourly
Glycopeptides
 Teicoplanin 12 mg/kg 12-hourly times 3 loading dose then 12 mg/kg 24-hourly
 Vancomycin 15–20 mg/kg/dose 8–12 hourly; in critically ill patients 25–30 mg/kg loading dose
Oxazolidinonees
 Linezolid 600 mg 12 hourly
Polymyxins
 Colistin US: 2.5 to 5 mg/kg CBA 8–12 hourly
Europe: 9 million IU 8–12 hourly as a slow intravenous; in critically ill patients 9 million IU loading dose as a slow intravenous
infusion
  1. Note–the above table provides general information, the susceptibility profile of individual organisms should be confirmed to guide antimicrobial therapy in all situations. Dosage should be adjusted according to the antibiotic's pharmacokinetic/pharmacodynamic profile in each patient
  2. Higher dosages may be used in septic shock