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Table 10 Meta-analysis about laparoscopic abdominal lavage

From: A historical review of surgery for peritonitis secondary to acute colonic diverticulitis: from Lockhart-Mummery to evidence-based medicine

  Cirocchi Ceresoli Angenete Marshall
All Hinchey Hinchey III Hinchey III Hinchey III Hinchey III
Post-operative mortality at index admission or within 30 days from index intervention RR 1.33, 95% CI 0.37 to 4.74 RR 3.01, 95% CI 0.48 to 18.93 OR 0.93; 95% C.I. 0.23–3.82; P = 0.92 RR 1.34, 95% CI 0.59–3.04 RR 1.34, 95% CI 0.37 to 4.79
Mortality at 90 days RR 1.27, 95% CI 0.60 to 2.69 Not performedj OR 0.83; 95% C.I. 0.32–2.11; P = 0.69 RR 0.86, 95% CI 0.40–1.83 RR 0.86, 95% CI 0.40 to 1.84
Mortality at 12 months RR 0.84, 95% CI 0.38 to 1.88 Not performedj OR 0.74 P = 0.51 RR 0.54, 95% CI 0.38–0.76  
Reoperation at index admission or within 30 days from index intervention RR 1.93, 95% CI 0.71 to 5.22 RR = 1.40, 95% CI 0.71 to 4.90 OR 3.75, P = 0.006 RR 1.34, 95% CI 0.59–3.04 RR 3.03, 95% CI 1.16 to 7.89
At 90 days follow reoperations Not analyzeda Not performedj NR RR 1.71, 95% CI 0.85–3.43 NR
At 12 months follow reoperations RR 0.57, 95% CI 0.39 to 0.86 Not performedj OR 0.32, P = 0.0004 RR 0.54, 95% CI 0.38–0.76 NR
Intra-abdominal abscesses at index admission or within 30 days from index intervention Not analyzedb Not performedj OR 3.50; 95% C.I. 1.79–6.86; P = 0.0003 NR NR
Intra-abdominal abscesses at 90 days RR = 2.54, 95% CI 1.34 to 4.83 Not performedj NR NR NR
Wound infections RR = 0.10, 95% CI 0.02 to 0.51 Not performedj OR 0.14; 95% C.I. 0.04–0.45; P = 0.0009 NR NR
Morbidity at 90 days Not performedj Not performedj OR 1.70; 95% C.I. 1.00–2.87; P = 0.05 NR NR
Presence of stoma at 12 months RR = 0.50, 95% CI 0.14 to 1.75 Not performedj OR 0.44 P = 0.27 NR RR 0.50, 95% CI 0.14 to 1.76
Operating time Not analyzedc Not performedj NR NR NR
Post-operative persistent peritonitis Not analyzedd Not performedj NR NR NR
Post-operative secondary peritonitis Not analyzede Not performedj NR NR NR
Length of post-operative hospital stay during index admission. WMD −2.03, 95% CI−2.59 to−1.47 Not performedj NR NR NR
Adverse events within 90 days by Dindo-Clavien grade I-II Not analyzedf Not performedj NR NR NR
Adverse events within 90 days by Dindo-Clavien grade IIIa Not analyzedg Not performedj NR NR NR
Adverse events within 90 days by Dindo-Clavien grade IIIb RR 1.40, 95% CI 0.47 to 4.17 Not performedj NR RR 1.46, 95% CI 0.99–2.20 NR
Adverse events within 90 days by Dindo-Clavien grade IVa RR 0.59, 95% CI 0.20 to 1.75 Not performedj NR NR NR
Adverse events within 90 days by Dindo-Clavien grade IVb RR 0.62, 95% CI 0.10 to 3.75 Not performedj NR NR NR
Total length of hospital stays within 12 months. Not analyzedh Not performedj NR NR NR
Quality of Life Not analyzedi Not performedj NR NR NR
Post-operative ICU admission NR NR NR NR RR 0.85, 95% CI 0.40 to 1.78
  1. NR not reported
  2. aTwo trials (LADIES and DILALA) reported this outcome, but the LADIES reported only the abscesses needing percutaneous drainage, differently the DILALA reported only the abscess underwent surgical reintervention
  3. bOnly one trial (SCANDIV) reported this outcome
  4. cThis outcome was reported in the SCANDIV although a definition of operating time was not provided. In the DILALA trial, the duration of surgery, and time between end of surgery and the end of anesthesia was reported. In the LADIES trial, the results of a comparative analysis were provided in the absence of the primary data. Because of the incongruous reports of operating time, for these reasons the analysis of this outcome was not performed
  5. dOnly the DILALA trial analyzed this outcome as persistent peritonitis
  6. eOnly the SCANDIV trial analyzed this outcome of persistent peritonitis
  7. fOnly the DILALA trial reported this outcome
  8. gOnly the DILALA trial reported this outcome
  9. hOnly the DILALA trial reported this outcome
  10. iAll the included trials reported this outcome; however, the data of quality of life questionnaires were not comparable
  11. jLack of data