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Table 9 RCTs about abdominal laparoscopic lavage: characteristics

From: A historical review of surgery for peritonitis secondary to acute colonic diverticulitis: from Lockhart-Mummery to evidence-based medicine

Name of trial Trial registry entries Type of trial Country Participants Inclusion criteria Exclusion criteria Study number Time of study
LADIES Identifier: NCT01317485 Multicentre two-armed randomised trial: 34 teaching hospitals and eight academic hospitals in Belgium, Italy, and the Netherlands The Netherlands Patients with generalised purulent and faecal peritonitis from sigmoid diverticulitis Clinical signs of peritonitis. Free gas on and/or diffuse fluid on CT LOLA arm: Only patients with purulent perforated diverticulitis without overt perforation Dementia Previous sigmoidectomy Prior pelvic irradiation, Chronic treatment with high-dose steroids (>20 mg daily) Being aged younger than 18 years or older than 85 years Preoperative shock needing inotropic support Patients with Hinchey I and II Patients with Hinchey IV peritonitis or overt perforation were excluded from the DIVA group LOLA arm: 264 DIVA arm: 212 LOLA arm: between July 2010, and the early termination of the trial February 2013
DILALA trial ISRCTN for clinical trials ISRCTN82208287 Multicentre randomised trial Sweden- Denmark Perforated non-faeculent diverticulitis Hinchey grade III at diagnostic laparoscopy, i.e. free fluid Hinchey grade I - II at laparoscopy i.e. no free fluid Hinchey grade IV at laparoscopy, i.e. gross faecal contamination. Other pathology than diverticulitis diagnosed as explanation of peritonitis 80 Between February 2010 until February 2014
SCANDIV Identifier: NCT01047462 Multicentre randomised trial Sweden- Norvey Perforated non-faeculent diverticulitis Patients with generalised peritonitis Pregnancy Bowel obstruction 199 Between February 2010 until June 2014