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Table 6 Grade of NET tumors according to the World Health Organization (WHO), considering the Mitotic index and Ki-67

From: Acute appendicitis, inflammatory appendiceal mass and the risk of a hidden malignant tumor: a systematic review of the literature

Grade NETs appendix Tumor differentiation
Low grade (G1) <2 mitoses /10 high power fields (HPF) or < Ki-67 < 3%. Well-differentiated
Intermediate grade (G2) 2–10 mitoses / 10 HPF or Ki-67 between 3 and 20%. Well-differentiated
High grade (G3) >10 mitoses / 10 HPF or Ki-67 > 20%. Poorly differentiated