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Table 2 Main characteristics of the antibiotics used for the treatment of SSIs due to MRSA [8]

From: Early recognition of methicillin-resistant Staphylococcus aureus surgical site infections using risk and protective factors identified by a group of Italian surgeons through Delphi method

Antibiotic

Bactericidal activity; pharmacodynamics; anti-biofilm activity

Route of administration

Doses

Adverse events

Interactions

Cost (for a 70 kg person)

Teicoplanin

Bactericidal with low MIC; time-dependent; None

iv, im

7-10 mg/Kg once daily, loading dose

Renal toxicity

None

€50-70/day

Vancomycin

Bactericidal with low MIC; time-dependent; None

iv

1 g twice daily, 500 mg four times a day

Renal toxicity

Other nephrotoxic drugs

€5/day

Daptomycin

Bactericidal; concentration-dependent; Yes

iv

4-6 mg/kg

Myotoxicity

Statins

€80-120/day

Linezolid

Bacteriostatic; time-dependent; None

iv, oral

1200 mg once daily

Bone marrow toxicity, neuropathy, serotoninergic syndrome

SSRIs

€120/day

Tigecycline

Bacteriostatic; time-dependent; Partial

iv

50 mg twice daily; 100 mg loading dose

Nausea, vomiting, pancreatitis

None

€120/day

Ceftaroline

Bactericidal; time-dependent; None

iv

600 mg twice daily

Rash

None

€96/day

Dalbavancin

Bactericidal; concentration-dependent; Yes

iv

1000 mg day 1, 500 mg after 7 days; or 1500 mg one-shot

No

None

NA

Cotrimoxazole

Bactericidal; time-dependent; None

iv, oral

800/160 mg 3 times a day

Anemia

None

€15/day

Rifampin

Bactericidal; time-dependent; Yes

iv, oral

600 mg once a day

Liver toxicity

Several

€6/day

  1. iv intravenous, im intramuscular, SSRIs selective serotonin re-uptake inhibitors