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Table 4 Distribution of predictive variables and mortality at univariate analysis

From: Prospective Observational Study on acute Appendicitis Worldwide (POSAW)

Variables Patients
N = 4282 (%)
Dead
N = 12 (%)
Survivors
N = 4270 (%)
RR (CI 95%) p value
Age > 80 years 52 (1.2) 2 (16.7) 50 (1.2) 14.23 (3.90–51.96) < 0.05
Immunosuppression 71 (1.7) 3 (25.0) 68 (1.6) 15.70 (5.73–43.01) < 0.001
Severe cardiovascular disease 154 (3.6) 3 (25.0) 151 (3.5) 7.07 (2.62–19.07) < 0.05
Charlson Comorbidity Score > 5 23 (0.5) 4 (33.3) 19 (0.4) 74.91 (29.93–187.48) < 0.001
Previous episodes suspected app. 427 (10.0) 2 (16.7) 425 (10.0) 1.67 (0.47–5.95) 0.33
Previous antimicrobial therapy 327 (7.6) 4 (33.3) 323 (7.6) 4.40 (1.97–9.87) < 0.05
WBC > 10,000/ml 3434 (80.2) 10 (83.3) 3424 (80.2) 1.04 (0.81–1.33) 1.00
CRP > 50 mg/l 876 (20.5) 5 (41.7) 871 (20.4) 2.04 (1.04–4.00) 0.08
WSES Grading System
 Grade 0 145 (3.4) 0 144 (3.4) 0 1.00
 Stage 1 1896 (44.3) 3 (25.0) 1893 (44.3) 0.56 (0.21–1.50) 0.18a
 Stage 2a 632 (14.8) 0 632 (14.8) 0 0.23
 Stage 2b 129 (3.0) 1 (8.3) 128 (3.0) 2.78 (0.42–18.29) 0.31
 Stage 3a 332 (7.8) 0 332 (7.8) 0 0.62
 Stage 3b 181 (4.2) 0 181 (4.2) 0 1.00
 Stage 3c 73 (1.7) 2 (16.7) 71 (1.7) 10.02 (2.77–36.27) < 0.05
 Stage 4 376 (8.8) 6 (50.0) 370 (8.7) 5.75 (3.24–10.22) < 0.001
 Not reported 517 (12.1) 0 517 (12.1) NA NA
Pathology
 Normal 144 (3.4) 0 144 (3.4) 0 1.00
 Inflammation 1147 (26.8) 2 (16.7) 1145 (26.8) 0.62 (0.17–2.20) 0.53
 Periappendicitis 236 (5.5) 1 (8.3) 235 (5.5) 1.51 (0.23–9.92) 0.49
 Suppurative 1176 (27.5) 2 (16.7) 1174 (27.5) 0.61 (0.17–2.15) 0.53
 Gangrenous 673 (15.7) 2 (16.7) 671 (15.7) 1.06 (0.30–3.76) 1.00
 Perforation 256 (6.0) 4 (33.3) 252 (5.9) 5.65 (2.51–12.68) < 0.05
 Not reported 650 (15.2) 1 (8.3) 650 (15.2) NA NA
  1. All p values calculated using two-sided Fisher’s exact test unless otherwise noted
  2. RR risk ratio, CI confidence interval, NA not applicable
  3. aTwo-sided chi-square test