A combination of SOFA score and biomarkers gives a better prediction of septic AKI and in-hospital mortality in critically ill surgical patients: a pilot study

Table 4 Area under the ROC curve (AUROC) of significant variables regarding septic AKI and in-hospital mortality

Variables	Septic AKI				In-hospital mortality
Variables	AUROC	P value	Cutoff value	Sensitivity/specificity (%)	AUROC	P value	Cutoff value	Sensitivity/specificity (%)
Serum NGAL	0.991	< 0.001	413.2	92.3/100	0.768	0.021	385.3	75.0/64.3
Urinary NGAL	0.915	0.001	383.7	92.3/77.8	0.780	0.016	383.7	75.0/64.3
Serum calprotectin	0.889	0.002	219.8	84.6/88.9
Serum KIM-1	0.752	0.049	17.2	69.2/77.8
Urinary Cystatin C	0.641	0.271	118.9	53.8/66.7
Albumin	0.269	0.071	2.6	38.5/33.3	0.232	0.021	2.5	41.7/35.7
Creatinine	0.966	< 0.001	0.9	100.0/88.9	0.676	0.129	0.9	75.0/57.1
CRP	0.795	0.021	82.4	76.9/77.8
SOFA score	0.957	< 0.001	7.5	92.3/88.9	0.774	0.018	7.5	75.0/71.4
APACHE II Score	0.842	0.008	13.5	76.9/77.8	0.762	0.024	15.0	66.7/71.4
Serum NGAL+ Serum Calprotectin + SOFA score	1.000	< 0.001
Serum NGAL + urinary NGAL + SOFA score					0.911	< 0.001

AKI acute kidney injury, NGAL neutrophil gelatinase-associated lipocalin, SOFA Sequential Organ Failure Assessment, APACHE Acute Physiology and Chronic Health Evaluation

ISSN: 1749-7922