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Table 3 Clinical relevance of rs2232618 among trauma patients in the two cohorts

From: LBP rs2232618 polymorphism contributes to risk of sepsis after trauma

  Genotypes N Age (years) Sex (M/F, %) ISS Sepsis, n (%) MOD score
Southwest TT 1166 42.6 ± 12.8 81.4/18.6 20.8 ± 9.3 373 (32.0) 6.11 ± 2.24
TC 123 41.7 ± 13.9 77.2/22.8 25.0 ± 9.7 54 (43.9) 7.20 ± 2.23
CC 7 43.0 ± 10.7 100/0 24.1 ± 13.2 5 (71.4) 8.17 ± 3.19
  a1, b1, c1 a2
Southeast TT 388 41.3 ± 12.2 78.1/21.9 21.5 ± 9.3 136 (35.1) 5.88 ± 2.32
TC 54 42.1 ± 12.9 79.6/20.4 23.4 ± 9.3 29 (53.7) 7.39 ± 3.73
CC 3 32.7 ± 8.1 33.3/66.7 21.3 ± 7.2 2 (66.7) 6.00 ± 1.41
  a3, c2 a4
Total TT 1554 42.3 ± 12.6 80.6/19.4 21.0 ± 9.3 509 (33.0) 6.07 ± 2.24
TC 177 41.2 ± 13.7 92.1/7.9 22.5 ± 10.3 83 (46.9) 7.27 ± 2.87
CC 10 43.4 ± 12.1 80.0/20.0 23.8 ± 11.9 7 (70.0) 8.00 ± 2.94
  a5, b2, c3 a6
  1. Dominant effect (variant homozygotes + heterozygotes vs. wild homozygotes) as analyzed by ANCOVA: a1P = 0.002, a2P = 1.8E−6, a3P = 0.002, a4P = 0.005,a5P = 4.5 × 10−4, a6P = 1.4E−9
  2. Recessive effect (variant homozygotes vs. heterozygotes + wild homozygotes) as analyzed by ANCOVA: b1P = 0.032, b2P = 0.041
  3. Allele dose association by logistic regression: c1P = 0.001(OR = 1.77, 95% CI = 1.26–2.48), c2P = 0.006(OR = 2.11, 95% CI = 1.24–3.58), c3P = 0.005(OR = 1.54, 95% CI = 1.34–2.08)