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Table 3 Antibiotic regimens

From: 2017 WSES and SICG guidelines on acute calcolous cholecystitis in elderly population

a. Antimicrobial therapy for community-acquired cholecystitis
Choice Antibiotic class
(Best choice from 1 to 5)
Antibiotic choice
1 Beta-lactam/beta-lactamase inhibitor combinations based regimens Amoxicillin/Clavulanate (in stable patients)
Ticarcillin/Clavulanate (in stable patients)
Piperacillin/Tazobactam (in unstable patients)
2 Cephalosporins-based regimens Ceftriazone + Metranidazole
(in stable patients)
Cefepime + Metranidazole
(in unstable patients)
3 Carbapenem-based regimens Ertapenem
(in stable patients if risk factors for ESBLs)
4 Fluoroquinolone-based regimens (in case of allergy to beta-lactams) Ciprofloxacin + Metronidazole
(only in stable patients)
Levofloxacin + Metronidazole
(only in stable patients)
(only in stable patients)
5 Glycylcycline-based regimen Tigecycline (in stable patients if risk factors for ESBLs)
b. Antimicrobial therapy for heath care-associated
Clinical patient’s condition Antibiotic choice
Stable Tigecycline  +  Piperacillin/Tazobactam
Unstable Imipenem/Cilastatin ± Teicoplanin
Meropenem ± Teicoplanin
Doripenem ± Teicoplanin