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Table 2 Histopathologic score for severe acute porcine pancreatitis

From: Melatonin treatment of pigs with acute pancreatitis reduces inflammatory reaction of pancreatic tissue and enhances fitness score of pigs: experimental research

  Acinar necrosis Fatty tissue necrosis Intralobular inflammation (plasma cells, lymphocytes, and granulocytes outside parenchymal and fatty tissue necrosis) Edema Overall
Melatonin group 2.5 (0.0–3.0) 1.2 (0.0–3.0) 2.0 (0.3–3.0) 2.7 (1.0–3.0) 7.9 (3.0–12.0)
Non-melatonin group 2.7 (2.0–3.0) 2.0 (1.0–3.0) 2.5 (1.0–3.0) 3.0 (2.0–3.0) 9.7 (8.3–12.0)
P p = 0.025 p = 0.003 p = 0.150 p = 0.028 p = 0.006
Score Acinar necrosis Fatty tissue necrosis (in relation to plane) Intralobular Inflammation (plasma cells, lymphocytes, and granulocytes outside parenchymal and fatty tissue necrosis) Edema  
 0 Nil Nil Nil Nil  
 1 < 10 acinar cell necrosis/lobule < 1/3 of plane Loose infiltrates (≤ 30 cells/HPF) Interlobular edema  
 2 ≥ 10 acinar cell necrosis/lobule ≥ 1/3 to < 2/3 of plane Moderate infiltrates (> 30; ≤ 100 cells/HPF) Interacinar edema, ≥ 2 lobules  
 3 ≥ 1/3 of plane ≥ 2/3 of plane Dense infiltrates (> 100 cells/HPF) Intercellular edema, ≥ 2 lobules  
  1. Histopathologic pancreatitis total score ranges from 0 (no alterations) to maximal 12 points (severe pancreatitis); a high-power field (HPF) measures 0.3068 mm2
  2. HPF high-power field