Table 2 Histopathologic score for severe acute porcine pancreatitis

Melatonin group

2.5 (0.0–3.0)

1.2 (0.0–3.0)

2.0 (0.3–3.0)

2.7 (1.0–3.0)

7.9 (3.0–12.0)

Non-melatonin group

2.7 (2.0–3.0)

2.0 (1.0–3.0)

2.5 (1.0–3.0)

3.0 (2.0–3.0)

9.7 (8.3–12.0)

P

p = 0.025

p = 0.003

p = 0.150

p = 0.028

p = 0.006

Score

Acinar necrosis

Fatty tissue necrosis (in relation to plane)

Intralobular Inflammation (plasma cells, lymphocytes, and granulocytes outside parenchymal and fatty tissue necrosis)

Edema

 0

Nil

Nil

Nil

Nil

 1

< 10 acinar cell necrosis/lobule

< 1/3 of plane

Loose infiltrates (≤ 30 cells/HPF)

Interlobular edema

 2

≥ 10 acinar cell necrosis/lobule

≥ 1/3 to < 2/3 of plane

Moderate infiltrates (> 30; ≤ 100 cells/HPF)

Interacinar edema, ≥ 2 lobules

 3

≥ 1/3 of plane

≥ 2/3 of plane

Dense infiltrates (> 100 cells/HPF)

Intercellular edema, ≥ 2 lobules