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Table 1 Biological assays at baseline and after procedure in each group

From: New considerations on pathways involved in acute traumatic coagulopathy: the thrombin generation paradox

Biological test

Baseline

Group C90

Group T90

Group H90

Group TH90

p value

Trauma, shock, and hemorrhage

 pH

7.39 ± 0.01

7.36 ± 0.04 a

7.41 ± 0.01 ab

7.43 ± 0.02 b

7.45 ± 0.05 b†

0.049*

 Base excess (mmol/L)

0.4 ± 0.2

− 2.4 ± 0.3 a†

− 5.4 ± 0.8 b†

− 2.6 ± 0.5 a†

− 8.03 ± 0.9 c†

< 0.001*

 PCO2

43 ± 0.86

34.9 ± 2

29.6 ± 1.8 †

30.6 ± 1.9 †

30.8 ± 7.9 †

< 0.001*

 Bicarbonates

24.7 ± 0.8

19.1 ± 0.9 a†

18.1 ± 0.8 ab†

20.4 ± 0.5 a†

15.5 ± 0.8 †b

< 0.001*

 Lactates (mmol/L)

0.5 ± 0.1

1 ± 0.1 a†

0.9 ± 0.2 a†

1.3 ± 0.2 a†

2 ± 0.4 b†

< 0.001*

 Potassium (mmol/L)

3.51 ± 0.05

4.55 ± 0.22 a†

4.68 ± 0.13 a†

4.39 ± 0.13 a†

5.95 ± 0.33 b†

< 0.001*

 Hemoglobin (g/dL)

16.5 ± 0.1

14.8 ± 0.2 ab†

15.6 ± 0.3 a†

13.4 ± 0.6 c†

14.1 ± 0.3 bc†

< 0.001*

Thrombin generation

 Endogenous thrombin potential (nM/min)

269 ± 9

228 ± 23 a

262 ± 15 ab

297 ± 17 ab

312 ± 17 b

0.016*

 Lagtime(min)

2.07 ± 0.07

2.49 ± 0.10 †

2.38 ± 0.08 †

2.41 ± 0.14 †

2.47 ± 0.09 †

< 0.001*

 Peak (nmol/L)

93.0 ± 5.2

60.5 ± 6.7a†

73.6 ± 5.7 ab†

86.9 ± 6.8 b

79.2 ± 6.6 ab

0.009*

 Time to peak (min)

4.0 ± 0.1

4.3 ± 0.1 a†

4.1 ± 0.1 a

4.1 ± 0.1 a

4.5 ± 0.1 a†

0.02*

 Start tail(min)

53.6 ± 3.9

34.3 ± 4.2 a†

42.2 ± 3.2 a

52.8 ± 4.1 b

40.9 ± 4.3 a

0.02*

Platelets

 Platelets (platelets/L)

570 ± 8

517 ± 12 a†

533 ± 26 a

493 ± 17 a†

525 ± 15 a†

< 0.001*

 PAR-4 (AUC)

74.7 ± 2.5

69.4 ± 4.1

83.5 ± 7.0

63.3 ± 5.7

70.3 ± 4.7

0.146

 ADP (AUC)

91.0 ± 1.8

90.9 ± 4.1

100.0 ± 5.7

87.3 ± 4.4

85.3 ± 4.3

0.214

 COLL (AUC)

86.0 ± 2.0

77.4 ± 2.5 a†

84.3 ± 2.8 a

80.5 ± 3.6 a

75.5 ± 4.0 a†

0.047*

  1. Data are presented as mean ± SEM. Baseline, pooled values from all groups at 0 min; C90, control at 90 min; T90, trauma at 90 min; H90, hemorrhage at 90 min; TH90, trauma and hemorrhage at 90 min. *ANOVA I significance was designated at the p < 0.05 level of confidence. †Significant difference with baseline. Letter differences indicate statistical differences between groups. N = 15 per group