Skip to main content

Table 1 State Transitions - Variable Table

From: Salvage use of tissue plasminogen activator (tPA) in the setting of acute respiratory distress syndrome (ARDS) due to COVID-19 in the USA: a Markov decision analysis

VariableValueReference
Severe to Moderate ARDS45.0% in 7 daysBellani et al. 2016 [17]
Moderate to Severe ARDS12.7% in 7 daysBellani et al. 2016 [17]
Mild to Moderate ARDS25.8% in 7 daysBellani et al. 2016 [17]
Mild to Severe ARDS4.5% in 7 daysBellani et al. 2016 [17]
Mild ARDS to Floor/Recovery60% in 28 daysBellani et al. 2016 [17]
Severe ARDS Mortality40.9% in 28 daysBellani et al. 2016 [17]
Moderate ARDS Mortality35.0% in 28 daysBellani et al. 2016 [17]
Mild ARDS Mortality29.6% in 28 daysBellani et al. 2016 [17]
Mean Presenting PaO2/FiO2 Ratio (mm Hg), ICU-COVID Patients136 (IQR: 103-234)Wang et al. 2020 [6]
PaO2/FiO2 Ratio (mm Hg), for Salvage Use tPA60 
Mean Improvement PaO2/FiO2 Ratio (mm Hg), ICU-ARDS Patients170 (IQR: 135-225)Hardaway et al. 2001 [7]
Death or non-fatal disabling stroke following systemic tPA0.6%GUSTO-I Trial [18]