Table 2 Data on operative management and post-operative course
Study | Indications to surgery | technical note | IPN (%) | Collection | Time until necrosectomy from admission in days | Pathogens (most frequently found %) | Mortality (%) | Re-necrosectomies | New onset organ failure OF (%) | PF (%) | POB (%) | NB (%) | PEI (%) | Follow-up month |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Husu et al. [26] | *Infected pancreatic necrosis *Organ failure *Prolonged pain *Bleeding *Gastric outlet obstruction | Upper transvers subcostal laparotomy | 85/109 (77.9) | Not assessable 45 (41.3%) < 30% 31 (28.4%) 30–50% 11 (10.1%) > 50% 22 (20.2%) | 36 (22–59) | Nr | 25 (22.9) | 27 (24.7) | Nr | 43 39.4 | 11 10.1 | Nr | Nr | Nr |
Martinez et al. [27] | *Infected pancreatic necrosis *Necrotic pancreatitis *Organ failure | Longitudinal midline trans-peritoneal approach | 26/34 (76.4) | Nr | 10.5 (4–23) | -Yeast 10 (29.4) -Strept. Angin. 9 (26.5) -E. Coli 7 (20.6) | 7 (20.6) | 11/34 (32.4) | Nr | Nr | Nr | Nr | Nr | Nr |
Cao et al. [28] | *Infected pancreatic necrosis *Organ failure | *Trans-lesser sac approach 32 *Eetroperitoneal approach 11 *Combined 2 | 45 (100) | Ho 16 He 33 | 51.84 ± 28.48 | Nr | 4 (8.8) | Nr | Nr | 10 22.2 | 2 4.4 | 3 6.7 | 1 2.2 | 18 |
Šileikis et al [29] | *Infected pancreatic necrosis FNA *Suspected Infected pancreatic necrosis/Organ failure/sepsis | Nr | 42 (79.3) | Nr | 28.8 ± 14.0 | Nr | 34 (64.1) | Nr | Nr | 38 71.7 | Nr | Nr | Nr | |
Wroński et al [30] | *Confirmed or suspected Infected pancreatic necrosis FNA 17 *Persisting unwellness 5 | Transperitoneal necrosectomy -midline -subcostal | 17 (77.3) | < 30% 5 (22.7%) 30–50% 4 (18.2%) > 50% 9 (40.9%) | 40.5 (27–71) | Nr | 6 (27.3) | 12 (54.5) | 7 31.8 | 6 28.6 | Nr | Nr | Nr | |
Rash et al [31] | *Infected pancreatic necrosis FNA *Suspected Infected pancreatic necrosis/Organ failure/sepsis | 25/30 (83.3) | Nr | > 10 days after onset of symptom | Nr | 10 (33.3) | Median number of interventions 4 (r. 0–78) | Nr | Nr | Nr | 10 33.3 | Nr | Nr | |
Gomatos et al [32] | *Infected pancreatic necrosis *Organ failure/sepsis *Persisting unwellness | transperitoneal necrosectomy | 78 (65) | Not assessable 20 (16.7%) < 30% 27 (22.5%) 30–50% 34 (28.3%) > 50% 39 (32.5%) | 24 (12.8–42.3) | Nr | 28 (23.3) | 42 (35.0) | 14 11.7 | 18 15.0 | Nr | Nr | Nr | |
Barreda et al. [33] | *Infected pancreatic necrosis 31 *Organ failure 5 | / | 28/36 (77.7) | Nr | 38.5 (13–90) | E. coli 13 (46) | 6 (16.6) | Nr | nr | nr | nr | Nr | Nr | Nr |
Pupelis G et al [34] | *Infected pancreatic necrosis *Organ failure | Longitudinal midline or bilateral subcostal trans-peritoneal approach | 32 (82) | > 50% 22 (56.4%) | 22 (17–27) | E. coli Enterococcus | 5 (12.8) | Nr | 5 12.8 | 9 23.1 | Nr | Nr | Nr | |
Tan V et al [35] | *Infected pancreatic necrosis 21 | Bi-subcostal trans-peritoneal approach (cholecystectomy associated) post-operative irrigation | 19 (90) | Nr | 21 (3–120) | Nr | 3 (14) | Nr | 5 (17) | 8 38.0 | 3 14.0 | 4 19.0 | 4 19.0 | 16.1 |
Madenci et al [36] | *Infected pancreatic necrosis 43 *Failure to thrive 13 (19.1) *Sepsis syndrome 9 (13.2) *Biliary obstruction 2 (2.9) *Hemorrhage 1 (1.5) | Transmesocolic 47 (70.1%) Anterior 20 (30.3%) Retroperitoneal 3 (4.5%) | *Preop detected 43 (63) *Newly detected 11 (16.2) | Not assessable 7 (14.9%) < 30% 15 (31.9%) 30–50% 5 (10.6%) > 50% 20 (40.5%) | 39.5 (29–73) | Polymicrobial 19 (28) | 6 (8.8) | 10 (14.7) | 17 (25.0) | 49 74.2 | 12 17.7 | 14 20.6 | 7 10.3 | 23 |
Pascual et al [37] | *Infected pancreatic necrosis 21 | Open debridement, necrosectomy and drainage lavage | 21/21 (100) | Nr | 18.6 ± 16.9 (r = 1–76) | Nr | 9 (42.9) | Nr | 10 (47.7) | 6 28.6 | 4 19.0 | 4/12 | 2/12 | Nr |
Tu et al [38] | *Infected pancreatic necrosis *Organ failure | Longitudinal or crosscut incision; trans-lesser sac approach | 32/32 (100) | Nr | 18.3 (6–31) | Nr | 4 (12.5) | Nr | Nr | 11 | 2 | Nr | Nr | Nr |
Senthil Kumar et al [39] | *Infected pancreatic necrosis 15 | Transperitoneal necrosectomy | 15/15 (100) | He 15 | 31 (17–45) | Nr | 1 (6.7) | 2 | 3 | 1 | 5 | Nr | Nr | Nr |
Bausch et al [40] | *Infected pancreatic necrosis 1 *Organ failure/sepsis 16 *Other 13 | Transperitoneal necrosectomy | 25/30 (100) | Nr | 11 (0–77) | nr | 19 (63.3) | 22 | Nr | 5 | 8 | Nr | Nr | Nr |
Tan et al [41] | *Infected pancreatic necrosis 51 | Transperitoneal necrosectomy | 67/76 (88.6) | Nr | 30 (13–46) | Pseudomonas. | 3 (5.9%) | 1 | Nr | 28 | 3 | Nr | Nr | Nr |
Doctor et al [42] | *Infected pancreatic necrosis *Organ failure/sepsis *Persisting unwellness | Transperitoneal necrosectomy | 51 (83.6) | Nr | 29 (13–46) | E. coli, Klebsiella. Acinetobacter., Pseudomonas | 6 (9.8) | 2 | Nr | 31 (50.8) | 4 | Nr | Nr | Nr |
Boland et al [43] | *Infected pancreatic necrosis *Organ failure/sepsis | Open deb 9 (43%) Open CG 6 (29%) Lap deb 4 (19%) Lap CG 2(9%) | 21 (100) | Nr | 77 (32–155) | Enterococcus 8 Candida species 7 E. Coli 5 | 1 (open deb) | Nr | Nr | Nr | 1 (open deb) | Nr | Nr | Nr |
Raraty et al [11] | *Infected pancreatic necrosis FNA + 15 *Suspected Infected pancreatic necrosis/Organ failure/sepsis 13 | transperitoneal necrosectomy -Midline17 -Transvers11 | 15 (53.6) | > 50% 31 (60%) | 34 (5–149) | E. coli | 6 (21.4) | median number of interventions 1 (1–9) | Nr | 4 | Nr | Nr | Nr | Nr |
van Santvoort et al [13] | *Infected pancreatic necrosis FNA + *suspected Infected pancreatic necrosis/organ failure/sepsis | Surgical necrosectomies through bi-subcostal incision | 42 (93) | < 30% 19 (42%) 30–50% 10 (22%) > 50% 16 (36%) | 29 (12–155) | Nr | 7 (16) | 14 | 19 (42) | 17 (38) | 10 (22) | 17 (38) | 15 (33) | 6 |