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Table 3 The effectiveness of wound protectors [57,58,59,60,61,62,63]: characteristics of the studies included in the review. RCT: randomized controlled trial; SSI: surgical site infection; PCT: prospective controlled trial; GoR: grade of recommendation

From: Intraoperative surgical site infection control and prevention: a position paper and future addendum to WSES intra-abdominal infections guidelines

Author and year of publication Type of study Number of patients Outcomes GoR
Pinkney TD et al. 2013 [56] Multicenter RCT 760 Wound edge protection devices do not reduce the rate of surgical site infection in patients undergoing laparotomy, and therefore their routine use for this role cannot be recommended. 1A
Gheorghe A et al. 2012 [57] Systematic review and meta-analysis of 2 PCT + 10 RCT 1933 Wound edge protectors may be efficient in reducing SSI rates in patients undergoing open abdominal surgery 1B
Edwards JP et al. 2012 [58] Meta-analysis of 6 RCT 1008 Wound protectors reduce rates of SSI after gastrointestinal and biliary surgery 1A
Mihaljevic AL et al. 2015 [59] Systematic review and meta-analysis of 16 RCT 3695 Wound edge protectors significantly reduce the rate of surgical site infections in open abdominal surgery 1B
Zhang MX et al. 2015 [60] Systematic review and meta-analysis of 11 RCT 2344 Wound edge protector reduces the incidence of SSI in patients receiving laparotomies, especially in the circumstance of dual-ring type and in contaminated incisions. In order to fully assess the effectiveness of WEP, large-scale and well-designed RCTs are still needed in the future. 1B
Kang SI et al. 2018 [61] Systematic review and meta-analysis of 14 RCT 2684 Potentially significant benefit from impervious plastic wound protector use, greater protective effect in using dual-ring protector than a single ring 1A
Sajid MS et al. 2017 [62] Systematic review and meta-analysis of 18 RCT 3808 Wound edge protector is associated with reduced incidence of overall SSI in clean-contaminated and contaminated wounds 1B
Bressan AK et al. 2018 [63] RCT 107 Among adult patients with intrabiliary stents, the use of a dual-ring wound protector during pancreaticoduodenectomy significantly reduces the risk of incisional SSI. 1A