TY - JOUR AU - Borzellino, Giuseppe AU - Khuri, Safi AU - Pisano, Michele AU - Mansour, Subhi AU - Allievi, Niccolò AU - Ansaloni, Luca AU - Kluger, Yoram PY - 2021 DA - 2021/03/25 TI - Timing of early laparoscopic cholecystectomy for acute calculous cholecystitis: a meta-analysis of randomized clinical trials JO - World Journal of Emergency Surgery SP - 16 VL - 16 IS - 1 AB - Early cholecystectomy for acute cholecystitis has proved to reduce hospital length of stay but with no benefit in morbidity when compared to delayed surgery. However, in the literature, early timing refers to cholecystectomy performed up to 96 h of admission or up to 1 week of the onset of symptoms. Considering the natural history of acute cholecystitis, the analysis based on such a range of early timings may have missed a potential advantage that could be hypothesized with an early timing of cholecystectomy limited to the initial phase of the disease. The review aimed to explore the hypothesis that adopting immediate cholecystectomy performed within 24 h of admission as early timing could reduce post-operative complications when compared to delayed cholecystectomy. SN - 1749-7922 UR - https://doi.org/10.1186/s13017-021-00360-5 DO - 10.1186/s13017-021-00360-5 ID - Borzellino2021 ER -