Hyperoxemia during resuscitation of trauma patients and increased intensive care unit length of stay: inverse probability of treatment weighting analysis

Yamamoto, Ryo; Fujishima, Seitaro; Sasaki, Junichi; Gando, Satoshi; Saitoh, Daizoh; Shiraishi, Atsushi; Kushimoto, Shigeki; Ogura, Hiroshi; Abe, Toshikazu; Mayumi, Toshihiko; Kotani, Joji; Nakada, Taka-aki; Shiino, Yasukazu; Tarui, Takehiko; Okamoto, Kohji; Sakamoto, Yuichiro; Shiraishi, Shin-Ichiro; Takuma, Kiyotsugu; Tsuruta, Ryosuke; Masuno, Tomohiko; Takeyama, Naoshi; Yamashita, Norio; Ikeda, Hiroto; Ueyama, Masashi; Hifumi, Toru; Yamakawa, Kazuma; Hagiwara, Akiyoshi; Otomo, Yasuhiro

doi:10.1186/s13017-021-00363-2

World Journal of Emergency Surgery

Table 1 Characteristics of patients with and without hyperoxemia

From: Hyperoxemia during resuscitation of trauma patients and increased intensive care unit length of stay: inverse probability of treatment weighting analysis

Case	Unadjusted			After IPW^a
	Hyperoxemia	Non-hyperoxemia	P value	Hyperoxemia	Non-hyperoxemia	P value
	58	186	P value	Hyperoxemia	Non-hyperoxemia	P value
Age, years, median (IQR)	49 (35–67)	60 (46–75)	0.022	50 (31–65)	53 (37–69)	0.175
Sex, male, n (%)	34 (58.6%)	126 (67.7%)	0.202	83 (64.8%)	85 (65.9%)	0.860
Injury mechanism, blunt, n (%)	56 (98.2%)	180 (97.3%)	1.000	123 (97.6%)	125 (97.7%)	1.000
Comorbidities (Charlson index), median (IQR)	0 (0–0)	0 (0–0)	0.281	0 (0–0)	0 (0–0)	0.007
Vital signs on arrival, median (IQR)
GCS	6 (3–13)	14 (11–15)	< 0.001	8 (5–14)	10 (6–14)	0.557
RR	21 (18–28)	21 (18–26)	0.687	20 (16–26)	20 (15–28)	0.696
HR	96 (77–120)	90 (73–102)	0.083	96 (80–120)	90 (73–110)	0.153
BP systolic, mmHg	124 (90–147)	129 (103–154)	0.353	133 (103-151)	123 (83–158)	0.220
Injury severity, median (IQR)
AIS—head	4 (0–5)	2 (0–4)	< 0.001	4 (0–5)	4 (0–5)	0.663
AIS—chest	3 (0–4)	3 (0–4)	0.039	3 (0–4)	3 (0–4)	0.136
ISS	29 (25–38)	26 (19–34)	0.001	29 (25–38)	29 (25–38)	0.352
SOFA score	10 (8–11)	8 (6–10)	0.001	9 (7–11)	8 (7–11)	0.703
Cardiac arrest after arrival, n (%)	1 (1.7%)	2 (1.1%)	0.559	2 (1.6%)	4 (3.1%)	0.684
Treatment
Tube thoracotomy, n (%)	13 (22.4%)	44 (23.7%)	0.845	32 (25.0%)	40 (31.0%)	0.284
Intubation at ED, n (%)	47 (81.0%)	58 (31.2%)	< 0.001	90 (70.3%)	96 (74.4%)	0.462
Transfusion^b, U, median (IQR)
RBC	0 (0–4)	0 (0–2)	0.017	0 (0–4)	0 (0–6)	0.230
FFP	0 (0–6)	0 (0–4)	0.024	0 (0–4)	0 (0–6)	0.218
Platelet	0 (0–0)	0 (0–0)	0.276	0 (0–0)	0 (0–0)	0.178
Hemostatic procedure, n (%)
Craniotomy	19 (32.8%)	19 (10.5%)	< 0.001	37 (28.9%)	29 (23.2%)	0.301
Thoracotomy	2 (3.4%)	2 (1.1%)	0.248	4 (3.1%)	1 (0.8%)	0.181
Laparotomy	6 (10.3%)	13 (7.2%)	0.438	11 (8.7%)	10 (8.0%)	0.849
Angiography	21 (36.2%)	37 (20.4%)	0.015	34 (26.6%)	32 (25.4%)	0.832

IPW inverse probability weighting, GCS Glasgow Coma Scale, RR respiratory rate, HR heart rate, BP blood pressure, AIS Abbreviated Injury Scale, ISS Injury Severity Score, SOFA sequential organ failure assessment, ED emergency department, RBC red blood cell, FFP flesh frozen plasma
^aIPW was performed using propensity scores, and data were presented after excluding patients with propensity score of < 0.1 or > 0.9 ^bAmount of transfusion was calculated until 3 h after hospital arrival

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ISSN: 1749-7922

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