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Table 2 Univariate analysis of physiological parameters in open abdomen and matched control group

From: Who would benefit from open abdomen in severe acute pancreatitis?—a matched case-control study

 

Open abdomen (n = 47)

Matched controls (n = 47)

P

MAP lowest (24 h) ± SD, mmHg *

63 ± 9

67 ± 10

0.092

MAP mean ± SD, mmHg

79 ± 8

85 ± 11

0.004

IAP highest (24 h), ± SD, mmHg *

24 ± 4

21 ± 5

< 0.001

IAP mean ± SD, mmHg †‡

20 ± 3

17 ± 3

< 0.001

APP lowest (24 h), ± SD, mmHg *

46 ± 9

56 ± 13

< 0.001

APP mean ± SD, mmHg †‡

58 ± 9

68 ± 11

< 0.001

Urine output lowest (24 h) ± SD, ml/h *

19 ± 29

41 ± 36

< 0.001

Urine output mean ± SD, ml/h

31 ± 31

72 ± 66

< 0.001

Plasma creatinine highest (24 h) ± SD, umol/L *

216 ± 163

213 ± 174

0.484

Plasma creatinine mean ± SD, umol/L

209 ± 159

181 ±146

0.064

Plasma urea highest (24 h) ± SD, mmol/L *

11.9 ± 9.0

13.2 ± 10.2

0.692

Plasma urea mean ± SD, mmol/L †‡

11.3 ± 8.5

11.3 ± 7.8

0.753

PaO2/FiO2 lowest (24 h) ± SD *

142 ± 58

140 ± 66

0.631

PaO2/FiO2 mean ± SD †

199 ± 65

207 ± 76

0.973

Blood leucocyte count highest (24 h) ± SD, 109/L

18.7 ± 12.9

14.1 ± 7.8

0.119

Blood leucocyte count mean ± SD, 109/L

16.0 ± 9.1

11.9 ± 6.1

0.016

Platelet count lowest (24 h) ± SD, 109/L *

162 ± 122

120 ± 105

0.083

Platelet count mean ± SD, 109/L

142 ± 83

142 ± 114

0.666

Plasma bilirubin highest (24 h) ± SD, umol/L *

45 ± 46

58 ± 51

0.041

Plasma bilirubin mean ± SD, umol/L

43 ± 41

48 ± 38

0.261

Plasma CRP highest (24 h) ± SD, mg/L *

319 ± 129

319 ± 170

0.725

Plasma CRP mean ± SD, mg/L

311 ± 128

273 ± 134

0.150

GCS lowest (24 h) (IQR) *

15 (13–15)

15 (14–15)

0.509

GCS mean (IQR)

15 (14–15)

15 (14–15)

0.672

Plasma lactate highest (24 h) ± SD, mmol/L *

4.8 ± 4.2

3.5 ± 2.6

0.403

Plasma lactate mean ± SD, mmol/L

4.5 ± 3.9

2.9 ± 2.6

0.014

Base-excess lowest (24 h) ± SD, mmol/L *

−8.0 ± 6.6

−7.6 ± 4.2

0.871

Base-excess mean ± SD, mmol/L

−7.5 ± 6.4

−5.1 ± 4.6

0.085

Arterial pH, mean ± SD ||

7.22 ± 0.14

7.29 ± 0.10

0.016

Serum potassium, mean ± SD, mmol/l ||

5.3 ± 1.1

4.6 ± 0.9

0.001

Serum sodium, mean ± SD, mmol/l ||

127 ± 5

130 ± 6

0.008

Cumulative excess fluid balance ± SD, ml

12267 ± 7374

8616 ± 6888

0.020

  1. *Mean of most divergent value within 24 h from laparostomy (OA group) vs. mean of most divergent value within entire follow-up period (matched controls)
  2. †Mean of all preceding values
  3. ‡One missing value in group open abdomen (n = 46)
  4. ||Mean of most divergent values within 24 h from ICU admission
  5. APP, abdominal perfusion pressure; CI, confidence interval; CRP, C-reactive protein; GCS, Glasgow coma scale; IAP, intra-abdominal pressure; IQR, interquartile range; MAP, mean arterial pressure; OR, odds ratio; SD, standard deviation