Table 3 Hypertonic saline after a damage control laparotomy. Randomized controlled clinical trial. Security items

Fluid balance

Day 1

2665.5 (678–261)

1828 (427–3344)

0.21³

Day 2

768 (106–1599)

387 (− 125–1165)

0.58³

Day 3

261 (− 32–950)

170 (− 136–580)

0.43³

Day 4

357 (− 280–729)

10 (− 811–557)

0.19³

Day 5

51.5 (− 1835–697)

133 (− 713–1101)

0.37³

Day 6

− 385 (− 1057–140)

60 (− 1200–580)

0.37³

Day 7

− 110 (− 1109–597)

267 (− 650–810)

0.68³

First 72 h

3957 (1767–5976)

2486 (650–5578)

0.29³

First 7 days

2998 (1278–6964)

3133 (− 1700–6603)

0.49³

Sodium concentration

Day 0

140 (138–143)

141 (139–142)

–

Day 1

140 (138.5–142)

148 (144.5–151)

 < 0.001³

Day 2

140 (138–143)

153 (150–157)

 < 0.001³

Day 3

141 (139–144)

157 (149–161)

 < 0.001³

Day 4

143 (140–146)

156 (146–160)

 < 0.001³

Day 5

143.5 (140–147)

151 (144–156.5)

0.006³

Day 6

144 (139–147)

149 (144–155)

0.031³

Day 7

144 (140–147)

143 (140–147)

0.95³

Chloride concentration

Day 0

105 (104–106)

106 (102–110)

0.65³

Day 1

105 (103–107)

114.5 (110.5–120.5)

 < 0.001³

Day 2

107 (104.5–108.5)

120 (116–128)

 < 0.001³

Day 3

106.5 (105–111)

124 (111–127)

 < 0.001³

Day 4

107.5 (104–112)

122 (111–127)

 < 0.001³

Day 5

106 (103–110)

115 (108–122)

0.008³

Day 6

108 (104–113)

113 (107–117)

0.08³

Day 7

107 (105–112)

108.5 (104–113)

0.58³

Osmolality

Day 0

299 (297–306)

306 (300–316)

0.03³

Day 3

297.5 (290–305)

324 (308–333)

0.001³

Number of subjects with SOFA score > 6, n (%)

13 (59.1%)

12 (48.0%)

0.32¹

RIFLE score

Serum creatinine increase > 50%

3

2

0.17²

Serum creatinine increase > 100%

2

0

Serum creatinine increase > 200%

0

3

ICU-free days in the first 30 days, median (IQR)

16 (1–23)

19 (11–24)

0.57³