Table 4 GRADE evidence certainty
No. of studies | Study design | Risk of bias | Certainty assessment | No. of patients | Effect | Certainty | Importance | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Inconsistency | Indirectness | Imprecision | Other considerations | Relative (95% CI) | Absolute (95% CI) | |||||||
Mortality rate | ||||||||||||
23 | Observational studies | Not serious | Not serious | Not serious | Not serious | None | 149/1448 (10.3%) | 4665/47704 (9.8%) | 0.522 – (0.403 to 0.677) | – | ⨁⨁◯◯ Low | CRITICAL |
Number of debridement | ||||||||||||
8 | Observational studies | Not serious | Serious a | Not serious | Not serious | None | 523 | 325 | – | 0.611 0 (0.012 higher to 1.211 higher) | ⨁◯◯◯ Very low | IMPORTANT |
Amputation rate | ||||||||||||
6 | Observational studies | Not serious | Not serious | Not serious | Not serious | None | 105/836 (12.6%) | 6729/45762 (14.7%) | 0.836 – (0.619 to 1.129) | – | ⨁⨁◯◯ Low | IMPORTANT |