Table 2 Summary of findings

In-hospital mortality

66 per 1000

82 per 1000 (42 to 157)

RR 1.24 (0.64 to 2.39)

522 (6 RCTs)

Very low^a,b

The evidence suggests fibrinogen concentrate results in a slight increase in in-hospital mortality

RBC transfusion 24 h

The mean RBC transfusion 24 h ranged from 0.62 to 6.82 Unit

MD 0 Unit (0.99 lower to 0.98 higher)

–

355 (6 RCTs)

Very low^a,b,c

Fibrinogen concentrate may reduce/have little to no effect on RBC transfusion 24 h but the evidence is very uncertain

FFP transfusion 24 h

The mean FFP transfusion 24 h ranged from 0 to 17.4 Unit

MD 2.61 Unit higher (0.07 higher to 5.16 higher)

–

295 (5 RCTs)

Low^b,c

Fibrinogen concentrate probably increases FFP transfusion 24 h

PC transfusion 24 h

The mean PC transfusion 24 h ranged from 0.64 to 2.98 Unit

MD 0.46 Unit higher (0.17 higher to 0.76 higher)

–

187 (3 RCTs)

Moderate^b

Fibrinogen concentrate likely results in a large increase in PC transfusion 24 h

Blood loss within 24 h

The mean blood loss within 24 h was 221.8 mL

MD 171 mL lower (400.35 lower to 58.35 higher)

–

55 (1 RCT)

Low^d

Fibrinogen concentrate may result in little to no difference in blood loss within 24 h

Thrombotic events

53 per 1000

38 per 1000 (17 to 83)

RR 0.71 (0.32 to 1.58)

529 (6 RCTs)

Very low^a,b

Fibrinogen concentrate likely results in little to no difference in thrombotic events

Multiple organ failure

500 per 1000

270 per 1000 (90 to 780)

RR 0.54 (0.18 to 1.56)

154 (2 RCTs)

Low^a,b

Fibrinogen concentrate may result in a slight reduction in multiple organ failure