Table 3 Baseline demographic characteristics of the study patients

Age, median (IQR^a), years

Septic shock^b

World Society of Emergency Surgery Sepsis Severity Score^c

Calgary PIRO Score^d

GCS^e, median (IQR)

APACHE II^f, median (IQR)

Arterial pH, mean (95% CI)

Base deficit, median (IQR)

Lactate, median (IQR)

INR^g, median (IQR)

Temperature, mean (95% CI)

APACHE II score^f, mean ± SDd

SOFA score^h, mean ± SDe

Charlson Comorbidity Index scoreⁱ, median (IQR)

Worst physiologic measurements prior to randomization, median (IQR)

 Systolic blood pressure, mmHg

 Temperature (injured patients), °C

 Temperature (sepsis patients), °C

 pH

 Lactate, mmol/L

 Base deficit, mmol/L

 INR

Fluid administration prior to randomization, median (IQR)

 PRBC^j, units

 FFP^k, units

 PRBC/FFP ratio

 Crystalloid, L

Patient location prior to OR admission—no. (%)

 Emergency Department

 Hospital ward

 Intensive Care Unit

Vasopressors required prior to randomization—no. (%)

Hours from sepsis diagnosis to laparotomy, median (IQR)

If allocated to OPEN

 Type of Negative pressure peritoneal therapy (NPPT) temporary abdominal closure (TAC) device