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Table 8 Predictors of mortality according to univariate and multivariate logistic regression analysis

From: Typhoid intestinal perforations at a University teaching hospital in Northwestern Tanzania: A surgical experience of 104 cases in a resource-limited setting

Independent (Predictor) Variable

Survivors (N/%)

Non-survivors (N/%)

Univariate analysis

Multivariate analysis

    
   

O.R.

95% C.I.

P-value

O.R.

95% C.I.

P-value

Age

        

≤ 40

77(79.4)

22(22.6)

      

> 40

5 (71.4)

2(28.6)

1.23

0.24-2.98

0.984

2.32

0.43-2.45

NS

Sex

        

Male

58 (77.3)

17(22.7)

      

Female

22 (75.9)

7 (24.1)

2.21

0.95-2.76

0.051

1.32

0.22-2.32

NS

Duration of illness

        

Within 14 days

64 (76.2)

20 (23.8)

      

After 14 days

16 (80.0)

4 (20.0)

1.11

0.57-1.98

0.454

1.67

0.78-2.11

NS

Perforation-admission interval

        

Within 24 hours

15 (93.7)

1 (6.3)

      

After 24 hours

65 (73.7)

23 (26.1)

2.43

1.34-3.54

0.024

1.67

1.12-3.43

0.003

Timing of operation

        

Within 24 hours

12(85.7)

2(14.3)

      

After 24 hours

68 (75.6)

22(24.4)

0.21

0.11-0.98

0.011

1.23

1.12-3.65

0.034

HIV status

        

Positive

3 (33.3)

6(66.7)

      

Negative

63 (79.7)

16 (20.3)

      

Not known

14 (87.5)

2 (12.5)

3.54

2.46-4.98

0.031

0.23

0.11-0.98

0.022

CD4+ count (cells/μl)

        

≤ 200

1(33.3)

2 (66.7)

      

> 200

3(75.0)

1(25.0)

5.34

3.45-6.98

0.004

4.54

3.23-6.87

0.000

Prehospital antibiotic therapy

        

Adequate

23 (88.5)

3 (11.5)

      

Inadequate

52 (72.2)

20 (27.8)

      

Not documented

7 (87.5)

1 (12.5)

2.87

2.11-4.50

0.021

3.11

1.45-7.86

0.006

ASA classes

        

I-II (Low risk group)

26 (92.9)

2 (7.1)

      

III-V (High risk group)

54 (71.1)

22 (28.9)

0.32

0.11-0.98

0.033

3.2

2.34-6.81

0.012

SBP on admission

        

≤ 90 mmHg

22 (61.1)

14 (38.9)

      

> 90 mmHg

58(85.3)

10 (14.7)

3.45

1.56-4.91

0.011

1.98

1.72-4.98

0.000

Type of peritonitis

        

Generalized

74(77.1)

22 (22.9)

      

Localized

6(75.0)

2(25.0)

1.95

0.98-2.75

0.967

0.32

0.11-1.63

NS

Amount of peritoneal fluid/pus

        

≤ 1000 mls

13 (86.7)

2 (13.3)

      

> 1000 ml

67(75.3)

22 (24.7)

1.52

1.18-2.22

0.023

1.22

1.09-1.76

0.011

Number of perforations

        

Single

71 (80.7)

17 (19.3)

      

Multiple

9 (56.2)

7(43.8)

1.54

1.11-4.87

0.012

2.89

2.33-5.98

0.007

Postoperative complications

        

Present

25 (61.0)

16 (39.0)

      

Absent

55 (87.3)

8 (12.7)

2.98

2.33-4.91

0.004

5.22

3.43-6.94

0.000

  1. Keys: N = Number of patients, C.I. = Confidence interval, O.R. = Odds ratio, SBP = Systolic blood pressure