From: 2013 WSES guidelines for management of intra-abdominal infections
 | Renal function | |||
---|---|---|---|---|
Antibiotic | Increased | Normal | Moderately impaired | Severely impaired |
Piperacillin/tazobatam | 16/2 g q24 h CI or 3.375 q6 h EI over 4 hours | 4/0.5 g q6 h | 3/0.375 g q6 h | 2/0.25 g q6 h |
Imipenem | 500 mg q4 h or 250 mg q3 h over 3 hours CI | 500 mg q6 h | 250 mg q6 h | 250 mg q12 h |
Meropenem | 1 g q6 h over 6 hours CI | 500 mg q6 h | 250 mg q6 h | 250 mg q12 h |
Ertapenem | ND | 1 g q24 h | 1 g q24 h | 500 mg q24 h |
Gentamycin | 9 to 10 mg/kg q24 hb | 7 mg/kg q24 h | 7 mg/kg q36–48 h | 7 mg/kg q48–96 h |
Amikacin | 20 mg/kg q24 h | 15 mg/kg q24 h | 15 mg/kg q36–48 hb | 15 mg/kg q48–96 h |
Ciprofloxacin | 600 mg q12 h or 400 mg q8 h | 400 mg q12 h | 400 mg q12 h | 400 mg q24 h |
Levofloxacin | 500 mg q12 h | 750 mg q24 h | 500 mg q24 h | 500 mg q48 h |
Vancomycin | 30 mg/kg q24 h CI | 500 mg q6 h | 500 mg q12 h | 500 mg q24–72 h |
Teicoplanin | LD 12 mg/kg q12 h for 3 to 4 doses; MD 6 mg/kg q12 h | LD 12 mg/kg q12 h for 3 to 4 doses; MD 4 to 6 mg/kg q12 h | LD 12 mg/kg q12 h for 3 to 4 doses; MD 2 to 4 mg/kg q12 h | LD 12 mg/kg q12 h for 3 to 4 doses; MD 2 to 4 mg/kg q24 h |
Tigecycline | LD 100 mg; MD 50 mg q12 h | LD 100 mg; MD 50 mg q12 h | LD 100 mg; MD 50 mg q12 h | LD 100 mg; MD 50 mg q12 h |