Current concept of abdominal sepsis: WSES position paper

Table 1 Recommended dosing regimens of the most frequently used renally excreted antimicrobials according to renal function[21]

	Renal function
Antibiotic	Increased	Normal	Moderately impaired	Severely impaired
Piperacillin/tazobatam	16/2 g q24 h CI or 3.375 q6 h EI over 4 hours	4/0.5 g q6 h	3/0.375 g q6 h	2/0.25 g q6 h
Imipenem	500 mg q4 h or 250 mg q3 h over 3 hours CI	500 mg q6 h	250 mg q6 h	250 mg q12 h
Meropenem	1 g q6 h over 6 hours CI	500 mg q6 h	250 mg q6 h	250 mg q12 h
Ertapenem	ND	1 g q24 h	1 g q24 h	500 mg q24 h
Gentamycin	9 to 10 mg/kg q24 h^b	7 mg/kg q24 h	7 mg/kg q36–48 h	7 mg/kg q48–96 h
Amikacin	20 mg/kg q24 h	15 mg/kg q24 h	15 mg/kg q36–48 h^b	15 mg/kg q48–96 h
Ciprofloxacin	600 mg q12 h or 400 mg q8 h	400 mg q12 h	400 mg q12 h	400 mg q24 h
Levofloxacin	500 mg q12 h	750 mg q24 h	500 mg q24 h	500 mg q48 h
Vancomycin	30 mg/kg q24 h CI	500 mg q6 h	500 mg q12 h	500 mg q24–72 h
Teicoplanin	LD 12 mg/kg q12 h for 3 to 4 doses; MD 6 mg/kg q12 h	LD 12 mg/kg q12 h for 3 to 4 doses; MD 4 to 6 mg/kg q12 h	LD 12 mg/kg q12 h for 3 to 4 doses; MD 2 to 4 mg/kg q12 h	LD 12 mg/kg q12 h for 3 to 4 doses; MD 2 to 4 mg/kg q24 h
Tigecycline	LD 100 mg; MD 50 mg q12 h	LD 100 mg; MD 50 mg q12 h	LD 100 mg; MD 50 mg q12 h	LD 100 mg; MD 50 mg q12 h

ISSN: 1749-7922