Table 1 A summary of the screening and selection criteria of studies

Inclusion Criteria

1. Uncomplicated Acute Appendicitis

 - Excluded perforation

 - Excluded intra-abdominal abscess

2. Mainly focus on adult population

3. Full article published in English

4. Randomized control trials & prospective comparative studies

Exclusion

1. Studies that solely involved the pediatric population (Subjects’ age < 18)

2. Studies that only compared elective surgery and conservative management

Search engine

1. PubMed

2. Embase (1980-)

3. Cochrane Library

Keywords

1. Acute appendicitis

2. Antibiotic therapy