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Table 3 Comparison of patients with antibiotics or drainage treatment regarding parameters available on admission

From: Determinants of treatment and outcomes of diverticular abscesses

 

Antibiotics success (n = 150)

Antibiotics failure (n = 29)

Univariate p

Multivariate OR (95% CI)

Drainage success (n = 18)

Drainage failure (n = 8)

p value

Sex female

93 (62%)

20 (69%)

0.53a

 

7 (39%)

4 (50%)

0.68c

Age, years, median (IQR)

61 (50–71)

60 (53–77)

0.63b

 

60 (53–71)

55 (35–69)

0.29b

WBC, ×109/l, median (IQR)

11.6 (9.3–14.5)

15.2 (11.2–18.8)

0.001b

 

11.1 (8.6–14.8)

11. (8.3–15.6)

0.82b

WBC ≥ 15.0

32 (21%)

15 (52%)

0.002a

3.3 (1.3–8.0)

3 (17%)

2 (25%)

0.63c

CRP, mg/l, median (IQR)

123 (82–169)

181 (92–272)

0.009b

 

126 (115–140)

122 (31–297)

0.89b

CRP over ≥175

35 (23%)

15 (52%)

0.003a

NS

6 (33%)

4 (50%)

0.66c

Abscess diameter, mm, median (IQR)

33 (22–45)

50 (36–76)

< 0.001b

 

59 (49–90)

67 (54–88)

0.61b

Abscess diameter ≥ 50 mm

29 (19%)

16 (55%)

< 0.001a

3.7 (1.5–8.9)

14 (78%)

7 (89%)

1c

Hemoglobin, g/l, median (IQR)

131 (123–140)

126 (113–140)

0.25b

 

123 (115–140)

121 (114–143)

0.98b

Anemicd

32 (21%)

11 (38%)

0.06a

NS

10 (56%)

4 (50%)

1c

Temperature on admission, °C, median (IQR)

37.5 (37.1–37.9), n = 146

37.3 (36.7–37.8), n = 27

0.14b

 

37.3 (36.9–37.6), n = 17

37.1 (36.4–38.1)

0.8b

MAP on admission, mmHg, median (IQR)

99 (92–108), n = 146

95 (87–104), n = 27

0.07 b

 

99 (91–111), n = 17

98 (87–113)

0.93b

Multiple abscesses

23 (15%)

3 (10%)

0.77c

 

2 (11%)

1 (13%)

1c

Intra-abdominal fluid in the fossa douglas

20 (13%)

4 (14%)

1c

 

0

1 (13%)

0.31c

Charlson Comorbidity Index, median (IQR)

2 (1–3)

3 (1–5)

0.08b

NS

2 (1–5)

2 (0–4)

0.5b

Corticosteroid medication

10 (7%)

7 (24%)

0.009c

3.9 (1.2–12.4)

4 (22%)

2 (25%)

1c

Any earlier diverticulitis

39 (26%)

10 (35%)

0.37c

 

6 (33%)

5 (63%)

0.22c

Earlier complicated diverticulitis

6 (4%)

3 (10%)

0.16c

NS

2 (11%)

4 (50%)

0.051c

Earlier abdominal surgerye

54 (36%)

14 (48%)

0.22a

 

5 (28%)

1 (13%)

0.63c

No guarding on admission

42 (28%)

12 (41%)

0.19a

NS

7 (39%)

6 (75%)

0.202c

Intra-abdominal or retroperitoneal air in CT (non-pericolic)

13 (9%)

6 (21%)

0.09c

NS

2 (11%)

1 (13%)

1c

Pelvic abscess

33 (22%)

12 (41%)

0.04a

NS

7 (39%)

4 (50%)

0.68c

Initially treated with antibiotics only

–

–

  

4 (22%)

1 (13%)

1c

  1. Patients whose treatment was started with antibiotics alone are also included in the drainage group. Parameters with univariate p < 0.2 were selected for the multivariate logistic regression model. Temperature and MAP were left out of the model due to clinically non-significant differences
  2. OR odds ratio, CI confidence interval, IQR interquartile range, WBC white blood cell count, CRP C-reactive protein, NS not selected in backward stepwise selection (likelihood ratio), CT computer tomography, MAP mean arterial pressure
  3. aχ2 test
  4. bMann-Whitney U test
  5. cFisher’s exact test
  6. dHemoglobin < 117 g/l for females or < 134 g/l for males
  7. eIncluding appendectomy, cholecystectomy, hysterectomy, gastrectomy, and resections of bowel
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World Journal of Emergency Surgery

ISSN: 1749-7922