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Table 1 Baseline study characteristics of necrotizing soft tissue infection studies assessing surgical timing

From: Time is of the essence when treating necrotizing soft tissue infections: a systematic review and meta-analysis

 Eligible studies
(n = 109)
Studies in meta-analyses
(n = 33)
Publication year, n (%)
 1989 and older8 (7)3 (9)
 1990–19997 (6)4 (12)
 2000–200929 (27)7 (21)
 2010–201965 (60)19 (58)
Continent where study was performeda, n (%)
 Africa8 (7)0 (0)
 Asia42 (39)14 (43)
 Europe23 (21)7 (21)
 North America32 (30)12 (36)
 Oceania3 (3)0 (0)
 South America0 (0)0 (0)
Type of studyb, n (%)
 Retrospective cohort study89 (90)27 (93)
 Prospective cohort study9 (9)2 (7)
 Randomized controlled trial1 (1)0 (0)
Study period in years, median (IQR; range)7 (5–11; 2–24)6 (5–11; 2–16)
Number of participating medical institutionsa, median (IQR; range)1 (1–1; 1–6)1 (1–1; 1–2)
Number of included patients per study, median (IQR; range)35 (20–67; 5–472)33 (20–84; 9–472)
Body regions affected by NSTI assed per study, n (%)
 Head and/or neck9 (8)1 (3)
 Extremities8 (8)3 (9)
 Trunk2 (2)1 (3)
 Fournier32 (29)4 (12)
 Full body58 (53)24 (73)
  1. IQR interquartile range, NSTI necrotizing soft tissue infection
  2. a1 missing case
  3. b10 missing cases