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Table 1 Demographic, clinical, and surgical characteristics

From: Antithrombotic drugs have a minimal effect on intraoperative blood loss during emergency surgery for generalized peritonitis: a nationwide retrospective cohort study in Japan

 

Before Matching

After Matching

AT

Control

Standardized difference

AT

Control

Standardized difference

Subjects

2947

67,158

 

2864

2864

 

Age, years (range)

77 (69–84)

70 (57–80)

− 0.561

77 (69–84)

78 (68–84)

− 0.008

Gender, Male

1884 (63.9%)

40067 (59.7%)

0.088

1815 (63.3%)

1795 (62.7%)

0.014

Body mass index (kg/m2)

21.5 (19.1–24.0)

21.0 (18.7–23.6)

− 0.026

21.5 (19.1–24.0)

21.3 (19.0–23.9)

− 0.014

Comorbidities

 Diabetes mellitus

767 (26.0%)

9460 (14.1%)

− 0.302

732 (25.6%)

721 (25.2%)

− 0.009

 Myocardial infarction

101 (3.4%)

296 (0.4%)

− 0.218

89 (3.1%)

77 (2.7%)

− 0.025

 Angina pectoris

172 (5.8%)

772 (1.1%)

− 0.257

150 (5.2%)

139 (4.9%)

− 0.018

 Congestive heart failure

336 (11.4%)

1171 (1.7%)

− 0.397

299 (10.4%)

254 (8.9%)

− 0.053

 Hypertension

1764 (59.9%)

21452 (31.9%)

− 0.584

1697 (59.3%)

1681 (58.7%)

− 0.011

 Cerebrovascular disease

572 (19.4%)

2644 (3.9%)

− 0.497

532 (18.6%)

523 (18.3%)

− 0.008

 COPD

189 (6.4%)

2045 (3.0%)

− 0.159

179 (6.3%)

166 (5.8%)

− 0.019

 CKD with hemodialysis

419 (14.2%)

2172 (3.2%)

− 0.397

388 (13.5%)

370 (12.9%)

− 0.019

 Advanced cancer with metastasis

150 (5.1%)

2993 (4.5%)

− 0.030

148 (5.2%)

158 (5.5%)

0.016

 Long-term steroid use

312 (10.6%)

2718 (4.0%)

− 0.253

292 (10.2%)

280 (9.8%)

− 0.014

Past intervention history

 PCI

393 (13.3%)

1123 (1.7%)

− 0.454

345 (12.0%)

299 (10.4%)

− 0.051

 Cardiac surgery

307 (10.4%)

853 (1.3%)

− 0.398

267 (9.3%)

224 (7.8%)

− 0.054

 Peripheral vascular surgery

157 (5.3%)

295 (0.4%)

− 0.295

126 (4.4%)

96 (3.4%)

− 0.054

Activities of daily living

  

0.429

  

0.005

 Independent

1901 (64.5%)

55728 (83.0%)

 

1873 (65.4%)

1868 (65.2%)

 

 Partial dependent

693 (23.5%)

7610 (11.3%)

 

656 (22.9%)

657 (22.9%)

 

 Complete dependent

353 (12.0%)

3819 (5.7%)

 

335 (11.7%)

339 (11.8%)

 

Smoking history

397 (13.5%)

14288 (21.3%)

0.207

388 (13.5%)

394 (13.8%)

0.006

Drinking history

1083 (36.8%)

27307 (40.7%)

0.080

1046 (36.5%)

1025 (35.8%)

− 0.016

Preoperative state

      

 Severe Sepsis/ Septic shock

614 (20.8%)

5981 (8.9%)

0.506

579 (20.2%)

558 (19.5%)

0.024

 Coagulopathy

201 (7.2%)

1209 (1.9%)

− 0.258

163 (6.0%)

163 (6.0%)

− 0.002

 Acute kidney injury

324 (11.0%)

2202 (3.3%)

− 0.303

305 (10.6%)

287 (10.0%)

− 0.021

 Mechanical ventilation

241 (8.2%)

1957 (2.9%)

− 0.232

226 (7.9%)

220 (7.7%)

− 0.008

 Performance status

  

0.717

  

0.026

  ASA-1E

53 (1.8%)

10540 (15.7%)

 

53 (1.9%)

60 (2.1%)

 

  ASA-2E

685 (23.2%)

26256 (39.1%)

 

681 (23.8%)

702 (24.5%)

 

  ASA-3E

1506 (51.1%)

22219 (33.1%)

 

1460 (51.0%)

1437 (50.2%)

 

  ASA-4E

512 (17.4%)

6035 (9.0%)

 

491 (17.1%)

488 (17.1%)

 

  ASA-5E

191 (6.5%)

2102 (3.1%)

 

179 (6.3%)

175 (6.1%)

 

Type of surgery

  

0.300

  

0.000

 Peritoneal lavage

906 (30.7%)

22468 (33.5%)

 

890 (31.1%)

890 (31.1%)

 

 Gastrectomy

17 (0.6%)

583 (0.9%)

 

14 (0.5%)

14 (0.5%)

 

 Patch repair of peptic ulcer

161 (5.5%)

7353 (10.9%)

 

157 (5.5%)

157 (5.5%)

 

 Other gastric surgery

9 (0.3%)

226 (0.3%)

 

8 (0.3%)

8 (0.3%)

 

 Colorectal resection

649 (22.0%)

11150 (16.6%)

 

636 (22.2%)

636 (22.2%)

 

 Other colorectal surgery

34 (1.2%)

708 (1.1%)

 

33 (1.2%)

33 (1.2%)

 

 Small bowel obstruction surgery

31 (1.1%)

588 (0.9%)

 

29 (1.0%)

29 (1.0%)

 

 Other small intestinal surgery

357 (12.1%)

5980 (8.9%)

 

344 (12.0%)

344 (12.0%)

 

 Stoma creation

476 (16.2%)

10002 (14.9%)

 

466 (16.3%)

466 (16.3%)

 

 Appendectomy

206 (7.0%)

6852 (10.2%)

 

194 (6.8%)

194 (6.8%)

 

 Cholecystectomy

92 (3.1%)

1089 (1.6%)

 

85 (3.0%)

85 (3.0%)

 

 Common bile duct surgery

9 (0.3%)

159 (0.2%)

 

8 (0.3%)

8 (0.3%)

 

Surgical approach

  

0.193

  

− 0.037

 Laparotomy

2688 (91.2%)

57074 (85.0%)

 

2611 (91.2%)

2640 (92.2%)

 

 Laparoscopy

259 (8.8%)

10084 (15.0%)

 

253 (8.8%)

224 (7.8%)

 

Surgery for cancer

258 (8.8%)

6822 (10.2%)

0.048

256 (8.9%)

276 (9.6%)

0.024

Hospital volume (procedure/year)

78 (40–149)

78 (38–148)

0.029

78 (40–149)

82 (40–152)

− 0.011

  1. Data are presented as number (percentage) or median (interquartile range)
  2. AT antithrombotic drug group, COPD chronic obstructive pulmonary disease, CKD chronic kidney disease, PCI percutaneous coronary intervention, ASA American Society of Anesthesiologist