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Table 1 Baseline study characteristics

From: Timing of pharmacologic venous thromboembolism prophylaxis initiation for trauma patients with nonoperatively managed blunt abdominal solid organ injury: a systematic review and meta-analysis

Study ID

Intervention groups

Year

Study design

Study center design

Patient population

Number of patients (n)

Adjustment for confounding

ISS

Mean(SD)

Median [IQR]

Age

Mean (SD)

Median [IQR]

Concurrent Head Injury

n (%)

Hospital LOS (days)

ICU LOS (days)

Alejandro et al. (N = 114)

≤ 48 h

2003

Retrospective cohort

Single center

Splenic injuries

50

None

18.5 (9.1)

36.7 (19.1)

12.5 (16.6)

11.2 (8.2)

> 48 h

    

64

 

16.8 (8.3)

38.3 (16.0)

 

10.8 (13.1)

14.7 (9.7)

Datta et al. (N = 72)

≤ 48 h

2009

Retrospective cohort

Multicenter

Hepatic injuries

27

None

22 (mean)

37 (mean)

0/27 (0)

14

8

> 48 h

    

45

 

25 (mean)

42 (mean)

0/45 (0)

26

9

Eberle et al. (N = 111)

< 72 h

2011

Retrospective cohort

Single center

Blunt SOI

41

Multivariable Regression

21.9 (9.7)

37.5 (15.7)

9/41 (22.0)

≥ 72 h

    

70

 

24.6 (10.0)

36.3 (14.3)

27/70 (40.0)

Joseph et al. (N = 116)

≤ 48 h

2015

Retrospective cohort

Single center

Blunt SOI

58

Propensity Score Matching

17 [12–19]

39.5 (18.2)

3.9 (2.9)

2.1 (1.9)

48–72 h

    

29

 

17 [14–24]

44.3 (21.4)

 

4.1 (3.6)

2.5 (2.1)

≥ 72 h

    

29

 

17 [13–26]

45.1 (22.9)

 

4.8 (4.1)

2.4 (2.3)

Rostas et al. (N = 328)

< 48 h

2015

Retrospective cohort

Multicenter

Blunt SOI

103

None

18.7 (mean)

3/103 (2.9)

48–72 h

    

54

 

22.6 (mean)

 

7/54 (13.0)

> 72 h

    

171

 

36.9 (mean)

 

12/171 (7.0)

Kwok et al. (N = 256)

< 24 h

2016

Retrospective cohort

Single center

Splenic injuries

23

None

19 [14–29]

40 (17)

0/23 (0)

13 (15.0)

5 (11.0)

24–48 h

    

91

   

0/91 (0)

8 (6.0)

2 (5.0)

48–72 h

    

65

   

0/65 (0)

14 (15.0)

7 (13.0)

> 72 h

    

77

   

0/77 (0)

17 (17.0)

8 (14.0)

Murphy et al. (N = 162)

< 48 h

2016

Retrospective cohort

Single center

Blunt SOI

78

None

21 (9)

43 (19)

0/78 (0)

7 [4–9]

3 [1–6]

≥ 48 h

    

84

 

17 (9)

41 (18)

0/84 (0)

4 [3–7]

4 [3–7]

Khatsilouskaya et al. (N = 142)

≤ 72 h

2017

Retrospective cohort

Single center

Blunt SOI

80

None

17 [11]

38.4 [29.4]

10/80 (12.5)

> 72 h

    

62

 

29 [21]

36.8 [30.7]

20/62 (32.3)

Schellenberg et al. (N = 118)

≤ 48 h

2019

Prospective cohort

Single center

Blunt SOI

61

None

17 [14–22]

36 [27–54]

5/61 (8.0)

6 [4–11]

3 [2–6]

> 48 h

    

57

 

22 [17–27]

36 [27–56]

18/57 (32.0)

14 [7–35]

7 [4–12]

Gaitanidis et al. (N = 3223)

< 48 h

2021

Retrospective cohort

Multicenter

Blunt SOI

1832

Multivariable Regression

14 [10–17]

34 [24–50]

0/1832 (0)

48–72 h

    

703

 

16 [13–20]

33 [24–52]

0/703 (0)

> 72 h

    

688

 

16 [13–21]

37 [25–55]

0/688 (0)

  1. SOI solid organ injury, ISS injury severity score, LOS length of stay