Outcome of necrotizing fasciitis and Fournier's gangrene with and without hyperbaric oxygen therapy: a retrospective analysis over 10 years

Table 6 Multivariate logistic regression models including potential determinants associated with mortality

	Characteristic	OR	95% CI	p
Baseline model^a	Female	1.02	0.50—2.06	0.958
	Age, y	1.03	1.01—1.06	0.017
	Problem localization^b	2.88	1.44—5.77	0.003
	Comorbidities, n	0.99	0.79—1.25	0.958
	LRINEC	1.00	0.89—1.13	0.992
Model 1	Debridements, n	0.83	0.76—0.91	< 0.001
Model 2	VAC therapy	0.17	0.08—0.36	< 0.001
Model 3	Mesh graft	0.06	0.03—0.16	< 0.001
Model 4	Flap	0.09	0.01—0.73	0.024
Model 5	Amputation	2.09	0.98—4.46	0.058
Model 6	HBOT, yes	1.06	0.49—2.30	0.884
	HBOT no, ineligible	8.59	1.90—38.86	0.005
Model 7	Positive blood culture	3.36	1.57—7.20	0.002
Model 8	Antibiotic groups, n	0.97	0.74—1.26	0.800
Model 9	ICU treatment	7.26	0.88—59.91	0.065
Model 10	Days in hospital	0.94	0.93—0.96	< 0.001
Model 11	Complications	10.35	3.35—32.07	< 0.001
Model 12	Infections	0.72	0.36—1.41	0.337
Model 13	Sepsis/organ dysfunction	19.58	8.06—48.20	< 0.001

OR Odds ratio, CI confidence interval, FG Fournier`s gangrene, HBOT hyperbaric oxygen therapy, ICU intensive care unit, LRINEC Laboratory Risk Indicator for NECrotizing fasciitis, n number, NF necrotizing fasciitis, VAC vacuum-assisted closure, y years
^aThe baseline model contained mortality as dependent variable and sex, age, problem localization, LRINEC and number of comorbidities as independent variables. In models 1–13, one additional parameter per model was integrated as independent variable. Age, number of comorbidities, number of debridements, number of antibiotic groups and days in hospital were included as continuous variables. The reference group for female was male. The reference category for "HBOT, yes" and "HBOT no, ineligible" contained patients who did not obtain HBOT because it was not indicated. Reference groups for all other parameters consisted of patients without the respective characteristic
^bThe category "problem localizations" comprised patients with NF or FG in the retroperitoneal area, head/neck region and/or in multiple localizations. Significant findings are highlighted in bold

ISSN: 1749-7922