The unrestricted global effort to complete the COOL trial

Kirkpatrick, Andrew W.; Coccolini, Federico; Tolonen, Matti; Minor, Samuel; Catena, Fausto; Gois, Emanuel; Doig, Christopher J.; Hill, Michael D.; Ansaloni, Luca; Chiarugi, Massimo; Tartaglia, Dario; Ioannidis, Orestis; Sugrue, Michael; Colak, Elif; Hameed, S. Morad; Lampela, Hanna; Agnoletti, Vanni; McKee, Jessica L.; Garraway, Naisan; Sartelli, Massimo; Ball, Chad G.; Parry, Neil G.; Voght, Kelly; Julien, Lisa; Kroeker, Jenna; Roberts, Derek J.; Faris, Peter; Tiruta, Corina; Moore, Ernest E.; Ammons, Lee Anne; Anestiadou, Elissavet; Bendinelli, Cino; Bouliaris, Konstantinos; Carroll, Rosemarry; Ceresoli, Marco; Favi, Francesco; Gurrado, Angela; Rezende-Neto, Joao; Isik, Arda; Cremonini, Camilla; Strambi, Silivia; Koukoulis, Georgios; Testini, Mario; Trpcic, Sandy; Pasculli, Alessandro; Picariello, Erika; Abu-Zidan, Fikri; Adeyeye, Ademola; Augustin, Goran; Alconchel, Felipe; Altinel, Yuksel; Hernandez Amin, Luz Adriana; Aranda-Narváez, José Manuel; Baraket, Oussama; Biffl, Walter L.; Baiocchi, Gian Luca; Bonavina, Luigi; Brisinda, Giuseppe; Cardinali, Luca; Celotti, Andrea; Chaouch, Mohamed; Chiarello, Maria; Costa, Gianluca; de’Angelis, Nicola; De Manzini, Nicolo; Delibegovic, Samir; Di Saverio, Salomone; De Simone, Belinda; Dubuisson, Vincent; Fransvea, Pietro; Garulli, Gianluca; Giordano, Alessio; Gomes, Carlos; Hayati, Firdaus; Huang, Jinjian; Ibrahim, Aini Fahriza; Huei, Tan Jih; Jailani, Ruhi Fadzlyana; Khan, Mansoor; Luna, Alfonso Palmieri; Malbrain, Manu L. N. G.; Marwah, Sanjay; McBeth, Paul; Mihailescu, Andrei; Morello, Alessia; Mulita, Francesk; Murzi, Valentina; Mohammad, Ahmad Tarmizi; Parmar, Simran; Pak, Ajay; Wong, Michael Pak-Kai; Pantalone, Desire; Podda, Mauro; Puccioni, Caterina; Rasa, Kemal; Ren, Jianan; Roscio, Francesco; Gonzalez-Sanchez, Antonio; Sganga, Gabriele; Scheiterle, Maximilian; Slavchev, Mihail; Smirnov, Dmitry; Tosi, Lorenzo; Trivedi, Anand; Vega, Jaime Andres Gonzalez; Waledziak, Maciej; Xenaki, Sofia; Winter, Desmond; Wu, Xiuwen; Zakaria, Andee Dzulkarnean; Zakaria, Zaidi

doi:10.1186/s13017-023-00500-z

World Journal of Emergency Surgery

Table 2 Overview of study outcomes

From: The unrestricted global effort to complete the COOL trial

	Indicator	Timeline
Primary outcome	Mortality	90 days
Secondary outcomes
Logistical	Days free of ICU	30 days
	Days free of ventilation	30 days
	Days free of RRT^a	30 days
	Days free of hospital	30 days
Physiological	APACHE II^b scoresup to	30 days^c
	SOFA^d scoresup to	30 days^c
	Pa02/Fi02^e ratiosup to	30 days^c
	ARDS^f scoresup to	30 days^c
Safety	enterocutaneous fistula	30 days
	ACS^g and/or severe IAH^h	30 days
	Intra-abdominal abscess	30 days
	Need for reoperation	30 days

^aRRT = Renal Replacement Therapy
^bAcute Physiology and Chronic Health Evaluation Score
^cMeasured daily using the worst value of that day
^dSOFA = Sequential organ Failure Assessment
^ePa0₂/Fi0₂ = Partial pressure of oxygen over inspired fraction of oxygen
^fARDS = Acute Respiratory Distress Syndrome
^gACS = Abdominal Compartment Syndrome
^hIAH = Intrabdominal Hypertension

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ISSN: 1749-7922

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