Table 1 Adverse physiology and goals of surgical source control

Microbiological (MB)

Invasive microbiological infections

Prevent growth of microbiologic organisms

GI Integrity (GIT)

Disruption of Gastrointestinal tract integrity

Restore Integrity of the gastrointestinal tract

Biomediator (BioM)

Systemic Propagation of Biomediators

Removal, mitigation, or down-regulation of Systemic biomediators

Physiology (Physiol)

Systemic elaboration of acid/base electrolyte Imbalance

Restore acid/base electrolyte physiology

Microbiome (MBiome)

Evolution from a healthy microbiome to a dysbiome

Minimize the negative selective pressures toward a dysbiome

Intra-abdominal hypertension (IAH/Ischem)

Visceral Ischemia resulting from severe

Intra-abdominal hypertension

Restore visceral perfusion through treatment of severe Intra-abdominal hypertension