Biomarker | N of studies, total (incl SBO) | N of patients AMI/total | Threshold (range) | Sensitivity | Specificity | LR+ | LR− |
---|---|---|---|---|---|---|---|
IMA | |||||||
2 (1) | 19/40 | 0.188–0.35 ABSU | 94.74 (70.61;99.26) | 90.48 (68.87; 97.61) | 7.21 (2.28; 18.90) | 0.18 (0.03; 0.48) | |
Transmural | 0 | ||||||
IL-6 | |||||||
2 (2) | 21/31 | 28–40 pg/mL | 100.00 (0.00;100.00) | 82.25 (31.72; 97.88) | 3.71 (1.42; 9.80) | 0.10 (0.01; 0.42) | |
2 (2) | 23/111 | 40–20000 pg/mL | 90.37 (64.07;98.02) | 82.91 (73.98; 89.22) | 4.71 (2.65; 7.99) | 0.19 (0.04; 0.49) | |
I-FABP | |||||||
Any stage (serum/plasma) [21, 39, 45, 46, 50, 56, 58, 64, 68, 69, 72, 77] | 12 (7) | 299/1334 | 90–100000 pg/mL | 73.59 (56.56;85.64) | 89.79 (79.17;95.31) | 4.72 (2.99; 7.26) | 0.37 (0.22; 0.54) |
4 (3) | 45/167 | 100–5787 pg/mL | 76.07 (26.79;96.50) | 92.05 (75.26;97.78) | 5.59 (2.19; 12.60) | 0.50 (0.31; 0.71) | |
2 (1) | 29/54 | 402–2520 pg/mL | 85.96 (68.23;94.58) | 72.00 (51.78;86.03) | 3.19 (1.66; 6.04) | 0.23 (0.07; 0.51) | |
2 (2) | 13/40 | 551–1000 pg/mL | 92.31 (60.94;98.93) | 85.22 (66.58;94.35) | 5.40 (2.24; 11.70) | 0.19 (0.04; 0.51) | |
PCT | |||||||
2 (1) | 130/1102 | 2–6.6 ng/mL | 79.11 (65.60;88.27) | 89.12 (81.51;93.83) | 7.28 (4.04; 12.30) | 0.22 (0.12; 0.36) | |
3 (2) | 158/285 | 0.25–5 ng/mL | 81.92 (75.14;87.17) | 80.41 (72.59;86.42) | 4.10 (2.85; 5.84) | 0.23 (0.16; 0.32) | |
Alpha-GST | |||||||
3 (1) | 57/151 | 4 ng/mL | 76.29 (14.96;98.33) | 84.83 (76.09;90.76) | 3.53 (1.16; 6.16) | 0.45 (0.07; 0.97) | |
Transmural | 0 | ||||||
D-dimer | |||||||
11 (6) | 234/1164 | 0.13–136 mg/L | 87.92 (77.05;94.04) | 69.22 (50.99; 82.94) | 2.43 (1.69; 3.57) | 0.26 (0.15; 0.40) | |
3 (1) | 28/294 | 0.3–2.796 mg/L | 87.56 (71.13;95.26) | 83.64 (37.47;97.76) | 5.78 (1.20; 23.20) | 0.27 (0.10; 0.61) | |
CRP | |||||||
6 (4) | 173/940 | 3–232 mg/L | 69.43 (31.32;91.88) | 90.22 (45.58;99.03) | 3.30 (1.19; 8.87) | 0.60 (0.47; 0.79) | |
2 (2) | 184/377 | 12.6–190 mg/L | 80.04 (56.67;92.47) | 76.51 (53.13;90.34) | 4.96 (0.85; 16.30) | 0.35 (0.05; 1.17) | |
D-Lactate | |||||||
5 (2) | 119/527 | 0.012–0.35 mmol/L | 88.53 (70.55;96.13) | 61.66 (27.32;87.31) | 2.49 (1.25; 5.65) | 0.23 (0.14; 0.38) | |
Transmural [40] | 1 (0) | 13/20 | 0.363 mmol/L | 38.46 (16.98;65.64) | 100.00 (0.00;100.00) | 17.80 (0.63; 107.00) | 0.72 (0.37; 1.36) |
NLR | |||||||
5 (3) | 307/692 | 2.55–17.9 | 72.62 (55.63;84.87) | 80.90 (67.40;89.67) | 4.59 (2.41; 8.23) | 0.33 (0.20; 0.50) | |
Transmural [33] | 1 (1) | 30/129 | 8.0 | 70.00 (51.66;83.59) | 23.30 (16.01;32.62) | 0.91 (0.66; 1.14) | 1.34 (0.64; 2.37) |
L-lactate | |||||||
Any stage [15, 17, 22, 23, 25, 28, 32, 34,35,36, 48, 50, 53, 54, 59] | 15 (12) | 604/2348 | 2.0–5.3 mmol/l | 72.99 (61.97;81.76) | 69.10 (53.39;81.37) | 2.21 (1.53; 3.26) | 0.36 (0.33; 0.60) |
7 (5) | 205/508 | 2.2–4.15 mmol/l | 72.96 (64.54;80.01) | 77.36 (57.05; 89.79) | 3.21 (1.64; 6.26) | 0.39 (0.28; 0.53) | |
RDW | |||||||
3 (1) | 176/472 | 13–14.7% | 61.74 (50.64;71.74) | 78.99 (64.22; 88.73) | 3.23 (1.79; 5.77) | 0.48 (0.37; 0.60) | |
Transmural | 0 | ||||||
LDH | |||||||
4 (3) | 118/539 | 147–420 U/L | 78.17 (63.60;88.01) | 61.42 (41.94;77.83) | 2.10 (1.24; 3.69) | 0.39 (0.19; 0.70) | |
2 (2) | 99/281 | 214–287 U/L | 70.71 (61.03;78.82) | 62.97 (55.72;69.67) | 2.59 (1.25; 5.43) | 0.44 (0.28; 0.72) | |
MPV | |||||||
4 (2) | 264/485 | 8.3–10.5 fL | 66.40 (50.99;78.96) | 70.51 (61.38; 78.24) | 2.26 (1.34; 3.51) | 0.50 (0.26; 0.80) | |
Transmural | 0 | ||||||
Citrulline | |||||||
2 (1) | 73/177 | 15.8–16.6 nmol/mL | 50.68 (39.3861.92) | 94.92 (46.57; 99.75) | 10.30 (1.41; 42.60) | 0.58 (0.43; 0.75) | |
Transmural | 0 | ||||||
WBC | |||||||
Any stage [13, 17, 18, 20, 31, 32, 35, 39, 46, 49, 50, 59, 72, 74, 81] | 15 (9) | 642/2107 | < 4 or > 15 × 109/L | 69.87 (60.83; 77.59) | 68.61 (52.47; 81.23) | 2.08 (1.39; 3.16) | 0.39 (0.34; 0.67) |
7 (4) | 219/1048 | < 4 or > 15 × 109/L | 70.92 (58.53;80.83) | 65.97 (59.55;71.84) | 2.00 (1.73; 2.30) | 0.47 (0.33; 0.63) | |
PLR | |||||||
Any stage [47] | 1 (0) | 125/138 | 250 | 31.20 (23.70; 9.83) | 100.00 (0.00;100.00) | 24.30 (0.80; 144.00) | 0.78 (0.62; 1.12) |
Transmural [16] | 1 0) | 27/168 | 124 | 75.00 (55.66;87.76) | 55.50 (47.22;63.48) | 1.68 (1.20; 2.18) | 0.47 (0.21; 0.82) |
pH | |||||||
3 (2) | 286/1194 | 7.2–7.35 | 52.01 (16.37;85.71) | 68.60 (26.21;93.08) | 1.69 (1.09; 2.86) | 0.71 (0.42; 0.95) | |
3 (1) | 36/181 | 7.245–7.35 | 54.15 (38.98;68.58) | 64.22 (55.95;71.72) | 1.48 (0.99; 2.05) | 0.74 (0.50; 1.00) | |
Bicarbonate | |||||||
Any stage | 0 | ||||||
3 (1) | 85/333 | 18–20 mmol/L | 27.38 (18.92;37.85) | 87.77 (67.50;96.13) | 2.73 (0.66; 8.66) | 0.87 (0.69; 1.22) |