Univariant analysis | Multivariant analysis | |||||||
---|---|---|---|---|---|---|---|---|
OR | IC95% inf | IC 95% sup | p value | OR | IC95% inf | IC 95% sup | p value | |
Gender | ||||||||
Male (ref) Female | 1.605 | 1.269 | 2.029 | .001 | – | – | – | – |
Age | 0.969 | 0.962 | 0.977 | .001 | – | – | – | – |
Scores | ||||||||
POSSUM Physiological score | .909 | .891 | .928 | .000 | .866 | .770 | .974 | .016 |
Total POSSUM | .912 | .896 | .929 | .000 | 1.120 | .999 | 1.256 | .051 |
APACHE II SCORE | .855 | .826 | .884 | .000 | – | – | – | – |
ASA score 1 (ref.) 2 3 4 5 | – .495 .221 .055 .000 | – .347 .152 .025 .000 | – .706 .322 .121 – | – .000 .000 .999 .999 | – 171,579,770.904 99,261,356.640 53,879,330.972 26,142,808.327 | – .000 .000 .000 .000 | – – – – – | .05 – .999 .999 .999 1.000 |
Charlson Comorbidity Score > 6 No Yes (ref.) | 4.452 | 2.764 | 7.170 | .000 | – | – | – | – |
Modified Frailty index 0 (ref) 1 2 3 4 5 6 7 8 | – .488 .381 .320 .302 .188 .050 .087 .000 | – .364 .266 .203 .159 .074 .006 .010 .000 | – .656 .544 .503 .573 .481 .409 .788 – | .000 – .000 .000 .000 .000 .000 .005 .030 1.000 | – | – | – | – |
Clinical data | ||||||||
Pulse (rpm) | 0.974 | .966 | .982 | .000 | 0.978 | 0.965 | 0.992 | .002 |
Temperature °C | 1.004 | .987 | 1.020 | .667 | – | – | – | – |
Hypertension requiring treatment | 2.232 | 1.761 | 2.828 | .000 | 2.157 | 1.415 | 3.286 | .001 |
DM treated with insulin or oral medications No Yes (ref.) | 1.885 | 1.408 | 2.524 | .000 | – | – | – | – |
Any liver disease No Yes (ref.) | 2.053 | 1.087 | 3.880 | .027 | – | – | – | – |
Time since beginning symptoms and surgery (days) | 1.002 | .999 | 1.006 | .256 | – | – | – | – |
Duration complaints > 72h No Yes (ref.) | 1.706 | 1.347 | 2.161 | .000 | – | – | – | – |
Palpable tender mass in the right upper abdominal quadrant No Yes (ref.) | 1.538 | 1.210 | 1.954 | .000 | 1.538 | 1.21 | 1.954 | .001 |
Oliguria No Yes (ref.) | 5.4 | 3.114 | 9.366 | .000 | 8.319 | 2.253 | 30.714 | .001 |
Serological tests | ||||||||
White blood cells > 18.000/mm3 No Yes (ref.) | 2.351 | 1.769 | 3.124 | .000 | – | – | – | – |
Hemoglobin | 1.004 | .999 | 1.009 | .132 | – | – | – | – |
Platelet count > 100,000/mm3 No Yes ref | 3.232 | 1.534 | 6.808 | .002 | – | – | – | – |
INR > 1.5 No Yes (ref.) | 4.840 | 2.942 | 7.964 | .000 | – | – | – | – |
Creatinine > 2mg/dL No Yes (ref.) | 6.132 | 3.610 | 10.419 | .000 | 4.331 | 1.272 | 14.748 | .019 |
Increased total bilirubin > 2 mg/dL? No Yes (ref.) | 3.004 | 2.210 | 4.083 | .000 | – | – | – | – |
Data about AC | ||||||||
Previous percutaneous cholecystostomy No Yes (ref.) | 5.944 | 2.529 | 13.969 | .000 | 6.603 | 1.734 | 25.148 | .006 |
Associated Common Bile Duct Stones (confirmed by EUS or MRI No Yes (ref.) | 3.664 | 2.185 | 6.145 | .000 | 3.954 | 1.681 | 9.300 | .002 |
Gangrenous cholecystitis No Yes (ref.) | 2.594 | 2.006 | 3.354 | .000 | 1.733 | 1.086 | 2.765 | .021 |
Pericholecystic abscess No Yes (ref.) | 3.918 | 2.743 | 5.595 | .000 | 3.001 | 1.501 | 5.998 | .002 |
Hepatic abscess No Yes (ref.) | 9.780 | 3.739 | 25.582 | .000 | – | – | – | – |
Biliary peritonitis No Yes (ref.) | 3.545 | 1.983 | 6.338 | .000 | – | – | – | – |
ACC grade 1 2 3 (ref.) | .443 .000 – | .340 .000 – | .578 – – | .000 .999 – | – | – | – | – |
*Operative time in min | .988 | .985 | .991 | .000 | .994 | .990 | .998 | .007 |
Bail out procedure? No Yes (ref.) | 6.674 | 4.194 | 10.621 | .000 | – | – | – | – |
Chole-Risk score 0 (ref.) 1 2 3 4 | .715 .483 .151 .039 | .505 .333 .089 .005 | 1.012 .701 .258 .315 | .000 – .058 .000 .000 .002 | – | – | – | – |
POSSUM Operative severity score < 15 > 15 (ref) | 12.137 | 5.434 | 27.110 | .000 | 8.453 | 2.073 | 34.462 | .003 |