- Open Access
Splenic trauma: WSES classification and guidelines for adult and pediatric patients
World Journal of Emergency Surgery volume 12, Article number: 40 (2017)
Spleen injuries are among the most frequent trauma-related injuries. At present, they are classified according to the anatomy of the injury. The optimal treatment strategy, however, should keep into consideration the hemodynamic status, the anatomic derangement, and the associated injuries. The management of splenic trauma patients aims to restore the homeostasis and the normal physiopathology especially considering the modern tools for bleeding management. Thus, the management of splenic trauma should be ultimately multidisciplinary and based on the physiology of the patient, the anatomy of the injury, and the associated lesions. Lastly, as the management of adults and children must be different, children should always be treated in dedicated pediatric trauma centers. In fact, the vast majority of pediatric patients with blunt splenic trauma can be managed non-operatively. This paper presents the World Society of Emergency Surgery (WSES) classification of splenic trauma and the management guidelines.
The management of splenic trauma has changed considerably in the last few decades especially in favor of non-operative management (NOM). NOM ranges from observation and monitoring alone to angiography/angioembolization (AG/AE) with the aim to preserve the spleen and its function, especially in children. These considerations were carried out considering the immunological function of the spleen and the high risk of immunological impairment in splenectomized patients. In contrast with liver traumatic injuries, splenic injuries can be fatal not only at the admission of the patient to the Emergency Department (ED), but also due to delayed subcapsular hematoma rupture or pseudoaneurism (PSA) rupture. Lastly, overwhelming post-splenectomy infections (OPSI) are a late cause of complications due to the lack of the immunological function of the spleen. For these reasons, standardized guidelines in the management of splenic trauma are necessary.
The existing classification of splenic trauma considered the anatomical lesions (Table 1). However, patients’ conditions may lead to an emergent transfer to the operating room (OR) without the opportunity to define the grade of the splenic lesions before the surgical exploration. This confirms the primary importance of the patient’s overall clinical condition in these settings. In addition, the modern tools in bleeding management have helped in adopting a conservative approach also in severe lesions. Trauma management must be multidisciplinary and requires an assessment of both the anatomical injury and its physiologic effects. The present guidelines and classification reconsider splenic lesions in the light of the physiopathologic status of the patient associated with the anatomic grade of injury and the other associated lesions.
Notes on the use of the guidelines
The guidelines are evidence-based, with the grade of recommendation also based on the evidence. The guidelines present the diagnostic and therapeutic methods for optimal management of spleen trauma. The practice guidelines promulgated in this work do not represent a standard of practice. They are suggested plans of care, based on best available evidence and the consensus of experts, but they do not exclude other approaches as being within the standard of practice. For example, they should not be used to compel adherence to a given method of medical management, which method should be finally determined after taking account of the conditions at the relevant medical institution (staff levels, experience, equipment, etc.) and the characteristics of the individual patient. However, responsibility for the results of treatment rests with those who are directly engaged therein, and not with the consensus group.
A computerized search was done by the bibliographer in different databanks (MEDLINE, Scopus, EMBASE) citations were included for the period between January 1980 and May 2016 using the primary search strategy: spleen, injuries, trauma, resuscitation, adult, pediatric, hemodynamic instability/stability, angioembolization, management, infection, follow-up, vaccination, and thrombo-prophylaxis combined with AND/OR. No search restrictions were imposed. The dates were selected to allow comprehensive published abstracts of clinical trials, consensus conference, comparative studies, congresses, guidelines, government publication, multicenter studies, systematic reviews, meta-analysis, large case series, original articles, and randomized controlled trials. Case reports and small cases series were excluded. Narrative review articles were also analyzed to determine other possible studies. Literature selection is reported in the flow chart (Fig. 1). The Level of evidence (LE) was evaluated using the GRADE system  (Table 2).
A group of experts in the field coordinated by a central coordinator was contacted to express their evidence-based opinion on several issues about the pediatric (< 15 years old) and adult splenic trauma. Splenic trauma were divided and assessed as type of injury (blunt and penetrating injury) and management (conservative and operative management). Through the Delphi process, the different issues were discussed in subsequent rounds. The central coordinator assembled the different answers derived from each round. Each version was then revised and improved. The definitive version was discussed during the WSES World Congress in May 2017 in Campinas, Brazil. The final version about which the agreement was reached resulted in present paper.
The WSES position paper suggested to group splenic injury into minor, moderate, and severe. This classification has not previously been clearly defined by the literature. Frequently low-grade AAST lesions (i.e., grades I–III) are considered as minor or moderate and treated with NOM. However, hemodynamically stable patients with high-grade lesions could be successfully treated non-operatively, especially exploiting the more advanced tools for bleeding management. On the other hand, “minor” lesions associated with hemodynamic instability often must be treated with OM. This demonstrates that the classification of spleen injuries into minor and major must consider both the anatomic AAST-OIS classification and the hemodynamic status.
The WSES classification divides spleen injuries into three classes:
Minor (WSES class I)
Moderate (WSES classes II and III)
Severe (WSES class IV)
The classification considers the AAST-OIS classification and the hemodynamic status and is the same for adult and pediatric patients. Table 3 explains the classification with the different key points of treatment differentiated within adult and pediatric patients; Table 4 resumes the guidelines statements.
Minor spleen injuries:
WSES class I includes hemodynamically stable AAST-OIS grade I–II blunt and penetrating lesions.
Moderate spleen injuries:
WSES class II includes hemodynamically stable AAST-OIS grade III blunt and penetrating lesions.
WSES class III includes hemodynamically stable AAST-OIS grade IV–V blunt and penetrating lesions.
Severe spleen injuries:
WSES class IV includes hemodynamically unstable AAST-OIS grade I–V blunt and penetrating lesions.
Physiopathology of injuries
Some mechanisms of injuries are similar between children and adults like motor vehicle crashes and pedestrian accidents, while others like motorcycle accidents, sport injuries, gunshot or stab-related injuries, and assaults are more frequent in adults .
A few authors consider a normal hemodynamic status in adults when the patient does not require fluids or blood to maintain blood pressure, without signs of hypoperfusion; hemodynamic stability in adults as a counterpart is the condition in which the patient achieve a constant or an amelioration of blood pressure after fluids with a blood pressure > 90 mmHg and heart rate < 100 bpm; hemodynamic instability in adults is the condition in which the patient has an admission systolic blood pressure < 90 mmHg, or > 90 mmHg but requiring bolus infusions/transfusions and/or vasopressor drugs and/or admission base excess (BE) > −5 mmol/l and/or shock index > 1 [3, 4] and/or transfusion requirement of at least 4–6 units of packed red blood cells within the first 24 h . The 9th edition of the Advanced Trauma Life Support (ATLS) definition considers as “unstable” the patient with the following: blood pressure < 90 mmHg and heart rate > 120 bpm, with evidence of skin vasoconstriction (cool, clammy, decreased capillary refill), altered level of consciousness and/or shortness of breath . Moreover, transient responder patients (those showing an initial response to adequate fluid resuscitation and then signs of ongoing loss and perfusion deficits) and, more in general, those responding to therapy but not amenable of sufficient stabilization to be undergone to interventional radiology treatments, are to be considered as unstable patients. In the management of severe bleeding, the early evaluation and correction of the trauma-induced coagulopathy remains a main cornerstone. Physiologic impairment is frequently associated with aggressive resuscitation and the activation and deactivation of several procoagulant and anticoagulant factors contributes to the insurgence of trauma-induced coagulopathy. The application of massive transfusion protocols (MTP) is of paramount importance. The advanced tailored evaluation of the patient’s coagulative asset is clearly demonstrated as fundamental in driving the administration of blood products, coagulation factors, and drugs [6,7,8,9].
The choice of diagnostic technique at admission must be based on the hemodynamic status of the patient (GoR 1A).
E-FAST is effective and rapid to detect free fluid (GoR 1A).
CT scan with intravenous contrast is the gold standard in hemodynamically stable or stabilized trauma patients (GoR 1A).
Doppler US and contrast-enhanced US are useful to evaluate splenic vascularization and in follow-up (GoR 1B).
Injury grade on CT scan, extent of free fluid, and the presence of PSA do not predict NOM failure or the need of OM (GoR 1B).
Extended focused assessment sonography for trauma (E-FAST) and ultrasonography (US) have replaced diagnostic peritoneal lavage (DPL) management of abdominal trauma in present days [5, 10, 11]. Studies have shown a sensitivity up to 91% and a specificity up to 96% also for a small fluid amount [12, 13].
Nevertheless, 42% of false-negative have been reported . This might be due to the 20% of cases in which no significant extravasation of blood is present in splenic trauma or in injuries near the diaphragm [10, 12, 13].
Contrast-enhanced US (CEUS) increases the visualization of a variety of splenic injuries and complications .
Doppler US (DUS) has been reported as safe and effective in evaluating PSA or blush previously found at CT scan .
Contrast tomography (CT) scan is considered the gold standard in trauma with a sensitivity and specificity for splenic injuries near to 96–100% [10, 15, 16]. However, Carr et al.  reported that CT scan can underestimate splenic injuries at ilum. CT must be rapidly available and must be performed only in hemodynamically stable patients or in those responding to fluid resuscitation [17, 18]. However, in some centers, there is the possibility to perform a fast-track CT scan that seems to permit to expand the criteria for performing CT scan in trauma patients. Delayed-phase CT helps in differentiating patients with active bleeding from those with contained vascular injuries . This is important to reduce the risk of discrepancy between CT scan images and angio images (only 47% of patients have a confirmation of the CT findings at angio) . Active contrast extravasation is a sign of active hemorrhage . The use of CT helps in surgical procedure and in AG/AE to be more selective [21, 22]. Contrast blush occurs in about 17% of cases and has been demonstrated to be an important predictor of failure of NOM (more than 60% of patients with blush failed NOM). Its absence on initial CT scan in high-grade splenic injuries does not definitively exclude active bleeding and should not preclude AG/AE [15, 23, 24]. Federle et al. showed that the hemoperitoneum quantification is not related to the risk of NOM failure .
Blunt and penetrating trauma:
Patients with hemodynamic stability and absence of other abdominal organ injuries requiring surgery should undergo an initial attempt of NOM irrespective of injury grade (GoR 2A).
NOM of moderate or severe spleen injuries should be considered only in an environment that provides capability for patient intensive monitoring, AG/AE, an immediately available OR and immediate access to blood and blood product or alternatively in presence of a rapid centralization system and only in patients with stable or stabilized hemodynamic and absence of other internal injuries requiring surgery (GoR 2A).
NOM in splenic injuries is contraindicated in the setting of unresponsive hemodynamic instability or other indicates for laparotomy (peritonitis, hollow organ injuries, bowel evisceration, impalement) (GoR 1A).
In patients being considered for NOM, CT scan with intravenous contrast should be performed to define the anatomic spleen injury and identify associated injuries (GoR 2A).
AG/AE may be considered the first-line intervention in patients with hemodynamic stability and arterial blush on CT scan irrespective from injury grade (GoR 2B).
Strong evidence exists that age above 55-years old, high ISS, and moderate to severe splenic injuries are prognostic factors for NOM failure. These patients require more intensive monitoring and higher index of suspicion (GoR 2B).
Age above 55 years old alone, large hemoperitoneum alone, hypotension before resuscitation, GCS < 12, and low hematocrit level at the admission, associated abdominal injuries, blush at CT scan, anticoagulation drugs, HIV disease, drug addiction, cirrhosis, and need for blood transfusions should be taken into account, but they are not absolute contraindications for NOM (GoR 2B).
In WSES classes II–III spleen injuries with associated severe traumatic brain injury, NOM could be considered only if rescue therapy (OR and/or AG/AE) is rapidly available; otherwise, splenectomy should be performed (GoR 1C).
NOM is considered the gold standard for the treatment of patients with blunt splenic trauma (BST) who are hemodynamically stable after an initial resuscitation, in the absence of peritonitis and associated injuries requiring laparotomy [15, 25,26,27,28]. In high-volume centers with all facilities, the successful rate of attempted NOM is near 90% . The advantages of NOM over OM were described as lower hospital costs, avoidance of non-therapeutic laparotomies, lower rates of intra-abdominal complications and of blood transfusions, lower mortality and the maintenance of the immunological function, and the prevention of OPSI [27, 30, 31]. Other guidelines have agreed the non-indication of routine laparotomy in hemodinamically stable patients with blunt splenic injury [32, 33].
NOM failure rate is reported to be between 4 and 15% [15, 29, 34,35,36,37,38,39,40,41,42,43,44]. Several risk factors of NOM failure have been reported [15, 29, 34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54].
In several studies, hemodynamic status at the admission has not been considered a significant prognostic indicator for NOM failure and, for this reason, should not be considered an absolute contraindication for NOM [15, 29, 36, 40, 41]. Others reported that the need for red cell transfusions in ED or during the first 24 h [40, 48], hemoglobin and hematocrit levels at admission , HIV disease, cirrhosis, and drug addiction [55,56,57] could affect the outcome after NOM.
The presence of a blush at CT scan has been considered a risk factor for NOM failure only in studies in which AG/AE was not adopted [46, 53]. In addition, the extension of hemoperitoneum at imaging alone cannot be considered an absolute contraindication for NOM [15, 19, 20, 40, 54].
Patients with higher ISS were more likely to fail NOM. According to the literature, two ISS values which were significantly associated with the failure of NOM were above 15  or 25 . This finding is in agreement with the increased risk of associated lesions in higher ISS.
GCS score below 12 alone should not be considered a contraindication for NOM as these patients can be successfully managed non-operatively with a reported overall NOM failure rate near 4.5% [15, 29, 40, 49].
The risk of NOM failure in patients older than 55 years is still debated. A few studies [15, 35, 37, 38, 41, 44, 52, 54] found older age to be a significant prognostic factor for NOM failure . On the other hand, other studies [29, 39, 43, 45, 50] did not find significant differences between patients ≤ 55 and > 55 years. It has been suggested that age> 55 years could be a risk factor for NOM failure only in high AAST-OIS injury grades [36, 38, 49]. Furthermore, the failure of NOM in older patients has been found to be associated with higher mortality rates and longer length of hospital stay than patients < 55 years .
Some authors suggested a primary OM in the presence of hypotension in the ED, more than five red blood cell transfused, GCS < 11, high ISS, abdominal AIS > 3, age > 55, and spleen AAST-OIS injury grade > 3. However, it has also been demonstrated that NOM could be successful also in high-risk patients without an increase in complications or mortality rates related to delayed operative interventions [15, 52].
According to larger studies on patients with BST , in level I trauma centers, NOM success rate is higher than in level II or III centers. Nevertheless, some authors stated that this might not be associated with the failure of NOM [42, 49].
Laparotomy has been the gold standard in penetrating abdominal trauma. Several studies demonstrated as the rate of negative laparotomy ranges between 9 and 14% [62, 63]. For the last 20 years, there has been an increased number of approaches with NOM for gunshot and stab injuries [64, 65].
Carlin et al. in a large series compared penetrating splenic trauma (248 patients) with blunt trauma and found that mortality was not significantly different . However, when the authors compared GSW and SW versus blunt splenic trauma, they found a significant difference in mortality (24 versus 15%, p = 0.02). Pancreatic, diaphragmatic, and colic injuries significantly increase the rate of OM approach and mortality for septic complications. The associated pancreatic injuries require frequently spleno-pancreatectomy . Demetriades et al. showed in a prospective study with 225 patients with penetrating splenic injury, the direct relationship between the degree of injury and the possibility of NOM vs. emergency laparotomy . Emergency laparotomy rate was 33% in grade I lesions, and it could increase up to 84% in the grade IV; all splenectomies were in injuries with grade III or higher.
Indication to angiography and angioembolization:
AG/AE may be performed in hemodynamically stable and rapid responder patients with moderate and severe lesions and in those with vascular injuries at CT scan (contrast blush, pseudo-aneurysms and arterio-venous fistula) (GoR 2A).
In patients with bleeding vascular injuries and in those with intraperitoneal blush, AG/AE should be performed as part of NOM only in centers where AG/AE is rapidly available. In other centers and in case of rapid hemodynamic deterioration, OM should be considered (GoR 2B).
In case of absence of blush during angiography, if blush was previously seen at CT scan, proximal angioembolization could be considered (GoR 2C).
AG/AE should be considered in all hemodynamically stable patients with WSES class III lesions, regardless the presence of CT blush (GoR 1B).
AG/AE could be considered in patients undergone to NOM, hemodynamically stable with sings of persistent hemorrhage regardless the presence of CT blush once excluded extra-splenic source of bleeding (GoR 1C).
Hemodynamically stable patients with WSES class II lesions without blush should not underwent routine AG/AE but may be considered for prophylactic proximal embolization in presence of risk factors for NOM failure (GoR 2B).
In presence of a single vascular abnormality (contrast blush, pseudo-aneurysms and artero-venous fistula) in minor and moderate injuries the currently available literature is inconclusive regarding whether proximal or distal embolization should be used. In presence of multiple splenic vascular abnormalities or in presence of a severe lesion, proximal or combined AG/AE should be used, after confirming the presence of a permissive pancreatic vascular anatomy (GoR 1C).
In performing AG/AE coils should be preferred to temporary agents (GoR 1C).
The reported success rate of NOM with AG/AE ranges from 86 to 100% with a success rate of AG/AE from 73 to 100% [68,69,70,71,72,73,74,75,76,77,78]. In a large study, Haan et al. suggested that indications to AG/AE were pseudo-aneurysms (PSA) or active bleeding at admission CT scan, significant hemoperitoneum, and high-grade splenic injury [68,69,70]. More than 80% of grade IV–V splenic injuries were successfully managed non-operatively with AG/AE. A large multicenter study  on 10,000 patients found that AG/AE was associated with a reduced odds of splenectomy and that the earlier AG/AE was performed; the less number of patients had splenectomy. A multi-institutional study by Banerjee et al. demonstrated that level I trauma center that had AG/AE rates greater than 10% had significantly higher spleen salvage rates and fewer NOM failure, especially for AAST-OIS grade III–IV injured spleen. AG/AE was also found as an independent predictor of spleen salvage and mortality reduction [78, 79].
A few meta-analyses showed a significant improvement in NOM success following introduction of AG/AE protocols (OR 0.26, 95% CI 0.13–0.53, p < 0.002) [54, 80,81,82]. The failure rate without AG/AE is significantly higher than with AG/AE in AAST-OIS grade IV–V injuries (43.7 vs. 17.3%, p = 0.035, and 83.1 vs. 25.0%, p = 0.016, respectively) .
Specific CT findings can help in the therapeutic decision, and they are correlated with outcomes. As such, patients with PSA and arterovenous fistula showed higher NOM failure rates [21, 22, 53, 83,84,85,86,87,88,89,90].
NOM failure in the presence of contrast blush treated without AG/AE ranges between 67 and 82% [53, 85]. Shanmuganathan et al. reported an 83% accuracy of blush in predicting the need for AG/AE . Marmery et al. showed a 4% of active bleeding vascular injuries in AAST-OIS grade I–II splenic injuries [21, 87]. Intraperitoneal splenic blush exhibited a significantly higher percentage of hemodynamic deterioration during the time required for AG/AE than intra-parenchymal bleedings (p < 0.001), suggesting intraperitoneal blush as an independent risk factor for OM .
Between 2.3 and 47% CT detected, contrast blush could not be confirmed at the subsequent angiography [89, 90]. The presence of a vascular injury is significantly associated with the splenic injury grade (p < 0.0001) . Moreover an analysis on 143 patients with blush at CT scan suggested that an angiographic procedure without embolization increases twofold the risk of re-bleeding and NOM failure .
The indication for routine prophylactic AG/AE in high-grade splenic injuries is a matter of controversy [23, 68, 70, 74, 85, 91,92,93]. Several retrospective and prospective studies recommended the use of AG/AE in all hemodynamically stable patients with high-grade splenic injuries [23, 91,92,93]. NOM failure rates both with and without prophylactic AG/AE for high-grade injuries are 0–42% vs. 23–67%, respectively, [23, 68, 70, 74, 85, 91].
Controversies exist regarding which kind of lesions should be considered as “high-grade” (AAST III–V or IV–V grade) and should undergo routine AG/AE [23, 68, 91, 92]. It has been reported that NOM could fail in up to 3% of grade III lesions without blush with no AG/AE . Furthermore, no outcome deterioration (in terms of NOM failure, rate of re-bleeding, complications, and mortality) was detected after excluding grade III injuries from routine AG/AE protocol . Therefore, considering the AG/AE-related morbidity of 47% (versus 10% related to NOM without AG/AE)  and the fact that widening the selection criteria for AG/AE from grades IV–V to grades III–V may slightly decrease the overall NOM failure rate, patients with grade III lesions without blush should not undergo routine AG/AE.
To date, no randomized comparing proximal and distal embolization are available . In a meta-analysis including 15 retrospective studies, proximal and distal embolization was found to be equivalent with regard to the incidence of major infarctions, infections, and major re-bleeding . However, a significant higher rate of overall minor complications was found after distal AE (2.8–11.6% versus 15.9–25.2%) .
Several studies analyzed the morbidity related to AG/AE, to OM, and to NOM without AG/AE [23, 68, 70, 96,97,98,99,100,101,102,103]. The AG/AE major morbidity rates range from 3.7 to 28.5% including re-bleeding, total or subtotal splenic infarction, splenic abscesses, acute renal insufficiency, pseudocysts, and puncture-related complications. The rates for minor morbidities range from 23 to 61%, and they included fever, pleural effusion, coil migration, and partial splenic infarction [70, 96, 102, 103]. All studies [97, 98, 101], but one  reported significantly higher complication rates in patients undergone OM (increased rate of death, infectious complications, pleural drainage, acute renal failure, and pancreatitis). In particular, the incidence of infectious complications was significantly higher in the splenectomy group (observation 4.8%, AG/AE 4.2%, splenorrhaphy 10.5%, splenectomy 32.0%, p = 0.001) .
Some studies analyzed the cost of NOM and AG/AE . They observed that NOM is safe and cost effective, and AG/AE is similar to surgical therapy with regard to cost.
Lastly, AG/AE does not seem to totally compromise the splenic function, and even in presence of an elevated leukocyte and platelet counts, no significant differences in immunoglobulin titers were found between splenic artery AG/AE patients and controls . The spleen due to its intense vascularization could assure the necessary blood to continue its immunological function.
Blunt trauma and penetrating:
OM should be performed in patients with hemodynamic instability and/or with associated lesions like peritonitis or bowel evisceration or impalement requiring surgical exploration (GoR 2A).
OM should be performed in moderate and severe lesions even in stable patients in centers where intensive monitoring cannot be performed and/or when AG/AE is not rapidly available (GoR 2A).
Splenectomy should be performed when NOM with AG/AE failed and patient remains hemodynamicaly unstable or shows a significant drop in hematocrit levels or continuous transfusion are required (GoR 2A).
During OM, salvage of at least a part of the spleen is debated and could not be suggested (GoR 2B)
Laparoscopic splenectomy in early trauma scenario in bleeding patients could not be recommended (GoR 2A).
Operative management (OM) of splenic injuries should be performed in non-responder hemodynamic instable patients. This condition is frequently observed in high-ISS trauma, in high-grade lesions, and in patients with associated lesions. However, it can be also required in low volume trauma centers or peripheral centers where no intensive care unit or intensive monitoring can be achieve [13, 105, 106]. It has been reported that isolated splenic injury is about 42% of all abdominal trauma . Multiple injuries are reported near 20–30% [107,108,109]. No sufficient data are available about concomitant vascular and splenic injuries. Associated hollow viscus injuries could be found in 5% of cases; the severity of splenic injury seems to be related to the incidence of hollow viscus injury (1.9, 2.4, 4.9, and 11.6% in minor, moderate, major, and massive injuries, respectively) .
The use of splenectomy is decreasing, and the use of splenorrhaphy is rarely adopted (35–24% and 6–1%, respectively) [108, 111]. The attempt to perform a partial splenic salvage is reported in 50–78% of cases, but when NOM fails, splenectomy is the preferred treatment [108, 111].
The use of splenic autologous transplantation (i.e., voluntarily leaving pieces of spleen inside the abdomen), to avoid infective risk from splenectomy, has been investigated, but no reduction of morbidity or mortality has been demonstrated .
The reported overall hospital mortality of splenectomy in trauma is near 2%, and the incidence of post-operative bleeding after splenectomy, ranges from 1.6 to 3%, but with mortality near to 20% .
Spleen injuries with concomitant spinal and brain injuries
Particular attention should be posed in managing hemodynamically stable patients with blunt spinal trauma (BST) and severe traumatic brain injury (STBI). A recent study in patients with concomitant spinal and/or brain associated to AAST-OIS grade IV–V spleen injuries reported a general survival benefit of immediate splenectomy over NOM . However, in centers where AG/AE is available (having therefore a lower NOM failure rate of high-grade splenic injuries), immediate splenectomy in patients with severe brain injury does not seem to be associated with an improved survival benefit regardless the grade of injury . It must be highlighted that the differences in definition of hemodynamic instability may represent a bias in this cohort of patients as a few “unstable” patients might have undergone NOM. This data strongly emphasizes the dangers related to poor patient selection for NOM in BST and STBI [34, 49].
Thrombo-prophylaxis in splenic trauma:
Mechanical prophylaxis is safe and should be considered in all patients without absolute contraindication to its use (GoR 2A).
Spleen trauma without ongoing bleeding is not an absolute contraindication to LMWH-based prophylactic anticoagulation (GoR 2A).
LMWH-based prophylactic anticoagulation should be started as soon as possible from trauma and may be safe in selected patients with blunt splenic injury undergone to NOM (GoR 2B).
In patient with oral anticoagulants the risk-benefit balance of reversal should be individualized (GoR 1C).
Trauma patients are at high risk of venous thromboembolism (VTE); the transition to a hyper-coagulation state occurs within 48 h from injury [117,118,119]. Without any prophylaxis, more than 50% may experience deep vein thrombosis (DVT)which substantially increases the risk of pulmonary embolism (PE) whose mortality is about 50% [117, 118]. In trauma patients surviving beyond the first 24 h, PE is the third leading cause of death. Even with chemical prophylaxis, DVT can be detected in 15% of patients. There are currently no standards for the initiation of prophylactic anticoagulation in trauma patients with blunt spleen injuries. A survey-based analysis from ASST reported a growing use of heparin according to the increasing grade of the splenic lesion, and on the contrary, an increasing use of low-molecular-weight heparin (LMWH) in low-grade lesions . Heparin and LMWH can be combined with mechanical prophylaxis; however, mechanical prophylaxis alone in high-grade lesions seems to be preferred by surgeons compared with heparin. Eberle et al.  and Alejandro et al.  demonstrated no differences between VTE prophylaxis administered within and after 72 and 48 h from trauma respectively, with highest rate of failure in patients with high-grade splenic injury. Bellal et al.  found no difference in hemorrhagic complication and NOM failure rate in patients with early (< 48 h), intermediate (48–72 h), and late (> 72 h) VTE prophylaxis. These considerations are referred to selected patients, particularly those without significant head and spinal injuries. As a counterpart, Rostas et al.  show that VTE rates were over fourfold greater when LMWH was administered after 72 h from admission.
When trauma occurs in patients under anticoagulants, it is important to consider, if it is necessary, the reversal of their effects in order to avoid thrombotic complication. However, failing to resume anticoagulation in a timely fashion is associated with poor outcomes .
Short- and long-term follow-up in NOM (blunt and penetrating)
Clinical and laboratory observation associated to bed rest in moderate and severe lesions is the cornerstone in the first 48–72 h follow-up (GoR 1C).
CT scan repetition during the admission should be considered in patients with moderate and severe lesions or in decreasing hematocrit, in the presence of vascular anomalies or underlying splenic pathology or coagulopathy, and in neurologically impaired patients (GoR 2A).
In the presence of underlying splenic pathology or coagulopathy and in neurologically impaired patients CT follow-up is to be considered after the discharge (GoR 2B).
Activity restriction may be suggested for 4–6 weeks in minor injuries and up to 2–4 months in moderate and severe injuries (GoR 2C).
Splenic complications after blunt splenic trauma range between 0 and 7.5% with a mortality of 7–18% in adults . In children, these incidences are lower [124,125,126,127]. The 19% of splenic-delayed ruptures happen within the first 48 h, more frequently between 4 and 10 days after trauma. The risk of splenectomy after discharge ranges between 3 and 146 days after injury, and the rate of readmission for splenectomy was 1.4% . Savage et al.  showed that approximately 2% of patients discharged with a non-healed spleen required late intervention. Savage et al.  found an average of healing in grades I–II of 12.5 days with a complete healing after 50 days while in grades III–V, 37.2 and 75 days, respectively. In 2–2.5 months, regardless of severity of spleen injury, the 84% of patients presented a complete healing . As a counterpart, Crawford et al. suggested that an early discharge is safe because late failure occurs infrequently [56, 130]. Mortality of late rupture ranges from 5 to 15% compared with 1% mortality in case of acute rupture [40, 131]. In any case, patients undergone NOM should be counseled to not remain alone or in isolated places for the first weeks after the discharge and they should be warned regarding the alert symptoms.
Radiological follow-up is used, but there are not clear information regarding the timing and type of imaging (CT vs. US); thus, imaging follow-up is usually based on clinical judgment and has been widely debated [18, 34, 40, 125, 132,133,134]. Management strategies that use patient education are more cost effective than to undergo imaging all patients until splenic complete healing.
In the short course (first 24–72 h), observation remains an essential part of low-grade splenic injury (AAST I–II grade); after the admission CT scan, serial abdominal examinations, and hematocrit determination every 6 h are necessary . Clancy et al.  showed as PSA were found in patients with grade II, even months after trauma, so they recommended CT scan at 36–72 h in all injuries [129, 131, 132]. Some authors suggest to repeat CT scan only in patients with decreasing hematocrit, in AAST grades III–IV, in patients with subcapsular hematoma, or underlying splenic pathology or coagulopathy, as also in neurologically impaired patients .
In the intermediate-long course recent reports recommended that routine post-discharge follow-up abdominal CT is not necessary in low-grade (AAST grade I or II) injuries .
More than 50% of patients present a healing at CT scan after 6 weeks, and subsequent image follow-up seems to have no clinical utility [24, 135]. Complete healing of almost all grades is observed 3 months after injury. Lynch et al. , in a prospective study, showed that mean time to US healing in AAST grade I, II, Ill, and IV injuries was 3.1, 8.2, 12.1, and 20.7 weeks, respectively. Soffer D. et al.  suggest a DUS for splenic lesion follow-up. Some authors have suggested the use of magnetic resonance images .
The role of radiological follow-up before returning to normal activity remains controversial. According to some authors, the return to normal activity can occur 3 weeks after splenectomy, and after 2.5–3 months after NOM [126, 134, 136, 137]. Other authors suggested activity restriction of 2 weeks for mild injuries with a return to full activity after 6 weeks, and up to 4–6 months for patients with more severe injuries [120, 129].
Pediatric splenic trauma
The spleen is the most commonly injured solid organ in pediatric blunt trauma patients (25–30%) [2, 138]. The age limit for pediatric patients is considered for present guidelines to be < 15 years old. While non-operative management of splenic trauma is the mainstay in children, the available clinical guidelines are not universally applied. In urban pediatric hospitals where resources facilitate the non-operative approach, the likelihood of splenic preservation with NOM ranges from 95 to 100% .
The Eastern Association for the Surgery of Trauma (EAST) recommends NOM in blunt splenic trauma in all hemodynamically stable children irrespective of the AAST injury grade [140, 141]. The same guidelines recommend a “less is more” approach with respect to imaging studies during admission and follow-up, aiming to reduce the use of CT scan and radiation exposure [140, 142].
NOM seems to be more effective in children, and therefore, it is more commonly used in these patients compared to adults NOM of pediatric splenic trauma which is also associated with reduced cost and lengths of hospital stay, less need for blood transfusions, vaccinations, and antibiotic therapy, as well as higher immunity and reduced rate of infections [142,143,144,145,146].
Even though it is not clear why NOM outcomes are superior in children compared with adults, this phenomenon may be related to certain unique pediatric characteristics (e.g., thicker splenic capsule, higher proportion of myoepithelial cells, more efficient contraction, and retraction of the splenic arterioles [147,148,149,150,151,152]).
Clinical presentation in splenic pediatric trauma
The mechanisms of trauma are similar in children and adults. These include motor vehicle and pedestrian injuries as well as sports-related injuries, bicycle injuries, and child abuse .
Pediatric injuries differ from adult trauma as the elastic pediatric rib cage may cause a transmission of force into the abdominal compartment .
Trauma in neonates represents a rare but unique diagnostic challenge since shock and abdominal rigidity or altered mental status may be the only indications of underlying abdominal injury .
In adolescents, the signs of splenic trauma may include the left upper quadrant pain associated with referred left shoulder pain hypovolemic shock or generalized abdominal pain .
Definition of the hemodynamic status in children
According to ATLS, the normal systolic blood pressure in children is 90 mmHg plus twice the child’s age in years (the lower limit is inferior to 70 mmHg plus twice the child’s age in years, or inferior to 50 mmHg in some studies) . Severe blood loss is defined as blood loss greater than 45% of the circulating volume and results in hemodynamic instability. Nevertheless, clinical judgment remains the most important factor in diagnosing an ongoing bleeding .
For fluid resuscitation, three boluses of 20 mL/kg of crystalloid replacement should be administered before blood replacement [5, 153]. Massive transfusion protocol in children should be applied with a ratio of 1:1:1 . Transfusion triggers have been debated, and although, there are no class I data to support a specific numerical threshold, it is generally agreed that transfusion should be considered when hemoglobin is less than 7 g/dL .
Effective resuscitation is classically indicated by reduction of the heart rate, improved mental status, return of peripheral pulses and normal skin color, increase in blood pressure, and urinary output, as well as increase in extremity warmth .
Even though the benefit of tromboelastography (TEG) has not been confirmed in children, recent ATOMAC guidelines suggested that it may be useful in these patients as well (based on adult data) .
The role of E-FAST in the diagnosis of pediatric spleen injury is still unclear (GoR 1A).
A positive E-FAST examination in children should be followed by an urgent CT in stable patients (GoR 1B).
Complete abdominal US may avoid the use of CT in stable patients (GoR 1B).
Contrast-enhanced CT scan is the gold standard in pediatric splenic trauma (GoR 1A).
Doppler US and contrast-enhanced US are useful to evaluate splenic vascularization (GoR 1B).
CT scan is suggested in children at risk for head and thoracic injuries, need for surgery, recurrent bleeding, and if other abdominal injuries are suspected (GoR 1A).
Injury grade on CT scan, free fluid amount, contrast blush, and the presence of pseudo-aneurysm do not predict NOM failure or the need for OM (GoR 1B).
Ultrasonography (US) is the less invasive and is considered the gold standard in trauma, according to the ATLS guidelines especially in Europe [5, 154]. The additional use of DUS or CEUS is helpful and can increase sensitivity for the evaluation of splenic flow and injuries . In patients with low clinical suspicion for splenic trauma, US and CEUS may allow to avoid CT scan . The routine use of CEUS can improve the search of PSA .
FAST (Focused Assessment with Sonography for Trauma): The role of FAST for the diagnosis of spleen injury in children is still unclear. Recent Pediatric Emergency Care Applied Research Network (PECARN) data suggest that only 13.7% of pediatric trauma patients with a suspicion of intra-abdominal injuries undergo FAST examination . The sensitivity of this imaging modality in children ranges from 50 to 92%, with a comprehensive meta-analysis suggesting the sensitivity to be around 66% [157,158,159].
The specificity of this exam is also quite low, and therefore, in a hemodynamically stable patient, a positive FAST examination should be followed by an urgent CT. Bedside FAST may have utility in hemodynamically unstable patients to rapidly identify or rule out intraperitoneal hemorrhage when patients cannot undergo CT.
Contrast-enhanced computer tomography (CT) is the gold standard for the evaluation of blunt abdominal trauma [2, 5]. However, patients should be hemodynamically stable, as well as cooperative or sedated. Of note, surgeons should interpret CT findings cautiously before opting for OM because more than 50% of children present with grade III–IV lesions [2, 160]. Taking into account the radiation risk in children, low-dose protocols are preferred (3–6 mSv instead of 11–24 mSv) [2, 5]. APSA guidelines recommend CT scanning in children at risk for injuries that might be missed by FAST, need for surgery, recurrent bleeding, and when other abdominal injuries (such as pancreatic or hollow viscous injury) are suspected .
Non-operative management in splenic injury:
NOM is recommended as first-line treatment for hemodynamically stable pediatric patients with blunt splenic trauma (GoR 2A).
Patients with moderate-severe blunt and all penetrating splenic injuries should be considered for transfer to dedicated pediatric trauma centers after hemodynamic stabilization (GoR2A).
NOM of spleen injuries in children should be considered only in an environment that provides capability for patient continuous monitoring, angiography, trained surgeons, an immediately available OR and immediate access to blood and blood products or alternatively in the presence of a rapid centralization system in those patients amenable to be transferred (GoR 2A).
NOM should be attempted even in the setting of concomitant head trauma; unless the patient is unstable, and this might be due to intra-abdominal bleeding (GoR 2B).
Blunt splenic injury:
Blunt splenic injuries with hemodynamic stability and absence of other internal injuries requiring surgery should undergo an initial attempt of NOM irrespective of injury grade (GoR 2A).
In hemodynamically stable children with isolated splenic injury splenectomy should be avoided (GoR 1A).
NOM is contraindicated in the presence of peritonitis, bowel evisceration, impalement, or other indications to laparotomy (GoR 2A).
The presence of contrast blush at CT scan is not an absolute indication for splenectomy or AG/AE in children (GoR 2B).
Intensive care unit admission in isolated splenic injury may be required only for moderate and severe lesions (GoR 2B).
Penetrating splenic injury:
No sufficient data validating NOM for penetrating spleen injury in children exist.
NOM is successful in 95–100% of blunt pediatric trauma patients and has therefore become the gold standard of treatment in children who have sustained an isolated blunt splenic injury and are hemodynamically stable at the time of presentation [139, 161]. AG/AE at present is considered among NOM tools by several authors.
APSA trauma committee recommendations have resulted in reduced ICU stay, hospital LOS, and resource utilization, while achieving superior outcomes [142, 162, 163]. In isolated spleen injuries, ICU stay should be considered in moderate-severe lesions [153, 160].
The CT-based solid organ grading system has not only been used to triage patients but also to administer the most appropriate treatment and to predict outcomes. However, the latter remains controversial [141, 164]. The CT-based solid organ grading system has not only been used to triage patients but also to administer the most appropriate treatment and to predict outcomes. However, the latter remains controversial [154, 161, 165,166,167]. Therefore, CT scan should not be the only factor guiding the diagnostic process; and some authors use this argument to avoid imaging in a stable patient altogether. Surprisingly, several studies have shown that adherence to APSA guidelines is low in non-pediatric trauma centers [145, 162, 168,169,170,171,172]. Pediatric trauma patients treated in dedicated centers were demonstrated to have higher probability to undergo NOM than those treated in adult trauma centers [145, 162, 168,169,170]. Mooney et al. and Todd et al. demonstrated that children with splenic injury have a greater chance to undergo splenectomy or laparotomy in general if treated in an adult trauma center [171, 173].
NOM failure rates for pediatric splenic trauma have been shown to range from 2 to 5% [174, 175]. Of note, there is evidence suggesting that the rate of NOM failure peaks at 4 h and then declines over 36 h from admission . Overall, the majority (72.5%) of NOM failures seem to occur during the first week after trauma, with 50% of them happening within the first 3–5 days .
Finally, there are no granular data validating NOM for penetrating spleen injury in children. However, reports on successful non-operative management of isolated penetrating spleen injuries in hemodynamically stable pediatric patients do exist [176,177,178].
The role of angiography/angioembolization (AG/AE):
The vast majority of pediatric patients do not require AG/AE for CT blush or moderate to severe injuries (GoR 1C).
AG/AE may be considered in patients undergone to NOM, hemodynamically stable with sings of persistent hemorrhage not amenable of NOM, regardless the presence of CT blush once excluded extra-splenic source of bleeding (GoR 1C).
AG/AE may be considered for the treatment of post-traumatic splenic pseudo-aneurysms prior to patient discharge (GoR 2C).
Patients with more than 15 years old should be managed according to adults AG/AE-protocols (GoR 1C).
Even though AG/AE appears to be a safe intervention, the vast majority of retrospective observational data show that very few pediatric patients with contrast extravasation may benefit from embolization [153, 181].
Therefore, AG/AE may only be considered in carefully selected patients, such as those with high-grade injuries, transient response to resuscitation, and/or persistent blood requirements . Similarly, the role of embolization in the management of pediatric splenic pseudo-aneurysms is also unclear. Of note, PSAs often undergo spontaneous thrombosis and could resolve without any interventions [133, 144, 155, 180, 183]. Some authors proposed a distinction between adolescent of more than 13–15 years old, for which should be applied the adult protocol for AG/AE, and children of less than 13–15 years old that are more vulnerable to OPSI [184, 185]. Moreover, Skattum et al. suggested that if a patient aged less than 15 years old is found to have a PSA on admission CT, contrast-enhanced ultrasound should be performed prior to discharge. If at that time PSA is still present, embolization should be considered .
Mortality and major complications are rarely reported following AG/AE [180, 184, 186, 187]. Nevertheless, a post-embolization syndrome (PES), consisting of abdominal pain, nausea, ileus, and fever, seems to occur in 90% of children undergoing AG/AE. This syndrome is usually self-limited and tends to resolve spontaneously in 6 to 9 days . In addition, pleural effusion (9%), pneumonia (9%), and coil migration (4.5%) can also be seen after splenic embolization .
Operative management in blunt and penetrating injuries:
Patients should undergo to OM in case of hemodynamic instability, failure of conservative treatments, severe coexisting injuries necessitating intervention and peritonitis, bowel evisceration, impalement (GoR 2A).
Splenic preservation (at least partial) should be attempted whenever possible (GoR 2B).
Indications for laparotomy include hemodynamic instability, ongoing blood loss, or evidence of hollow viscous injury [153, 161, 191,192,193,194]. Of note, ATOMAC guidelines recommend surgery if transfusion of 40 mL/kg of all blood products within 24 h (or more than 4 units of blood) fails to stabilize the patient hemodynamically [146, 153]. One percent (1%) of pediatric patients who undergo immediate OM are readmitted for intestinal obstruction within a year . In most cases of OM, splenic partial preservation is possible. Indeed, partial (subtotal) splenectomy or splenorrhaphy are safe and viable alternatives to total splenectomy and can be performed even in high-grade injuries [193, 195,196,197].
Splenic trauma associated with head injuries
Head injury is an important cause of morbidity and mortality in trauma patients of all ages (50–60%). Importantly, head injuries can also result in altered mental status, which can complicate the process of clinical evaluation . Especially in the setting of concurrent head injury, blood pressure and heart rate are poor markers of hemorrhagic shock in pediatric patients . Nevertheless, an analysis of the National Pediatric Trauma Registry suggested that the association of altered mental status from head injury with spleen injuries should not impact the decision for observational management in pediatric patients (< 19 years old) .
Short- and long-term follow-up in splenic trauma (blunt and penetrating):
In hemodynamic stable children without drop in hemoglobin levels for 24 h, bed rest should be suggested (GoR 2B).
The risk of pseudo-aneurysm after splenic trauma is low, and in most of cases, it resolves spontaneously (GoR 2B).
Angioembolization should be taken into consideration when a pesudoaneurysm is found (GoR 2B).
US (DUS, CEUS) follow-up seems reasonable to minimize the risk of life-threatening hemorrhage and associated complications in children (GoR 1B).
After NOM in moderate and severe injuries, the reprise of normal activity could be considered safe after at least 6 weeks (GoR 2B).
No definitive data exist regarding complication rate and short- and long-term follow-up, and no clear indications regarding the most cost-effective imaging technique (US, DUS, CEUS, CT scan). Initial APSA guidelines  recommended bed rest for a number of days equal to the grade of injury plus 1 day . However, recent studies suggest a shorter bed rest of one night in solitary grade I–II splenic trauma and two nights for patients with more severe injuries (grade ≥ III) and stable hemoglobin level . Longer admission should be considered in patients with lower hemoglobin levels on admission, higher injury grade, suspicious of other abdominal injuries (as pancreatic or small bowel injuries), blush on the CT scan, bicycle handlebar injuries, recurrent bleeding, or patients at risk for missed injuries [153, 165].
US or CEUS or DUS follow-up seems reasonable to minimize the risk of life-threatening hemorrhage and its associated complications . General surgeons tend to perform routinely imaging follow-up for children differently from pediatric surgeons that only in 5% of cases suggest imaging follow-up [145, 165, 201].
The APSA guidelines  recommended 2–5 months of “light” activity before restart with normal activities and recommended 3 week–3 months of limited activity at home. Some authors suggested the reprise of normal activity even after 4 weeks after III–IV grade injuries. In fact, the risks of delayed splenic rupture and post-traumatic pseudocysts seem to be increase within the first 3 weeks (incidence 0.2 and 0.3%, respectively) [142, 202]. Canadian guidelines suggested a discharge at home after reprise and good toleration of oral intake, able mobilization, and analgesia with oral medications without images before discharge . They reported a 32% of children that did not have any images follow-up without any complications and a restriction of activity no more than 6–8 weeks with a length of activity restriction modulated on the grade of injury . The use of CEUS can improve the diagnosis of PSA that can be found in all grades of injury .
Patients and parents psychological involvement after trauma can be related with abdominal pain; for this reason, family and patient education post-discharge should be considered to reduce readmission rate .
Infection prophylaxis in asplenic and hyposplenic adult and pediatric patients:
Patients should receive immunization against the encapsulated bacteria (Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis) (GoR 1A).
Vaccination programs should be started no sooner than 14 days after splenectomy or spleen total vascular exclusion (GoR 2C).
In patients discharged before 15 days after splenectomy or angioembolization, where the risk to miss vaccination is deemed high, the best choice is to vaccinate before discharge (GoR 1B).
Annual immunization against seasonal flu is recommended for all patients over 6 months of age (GoR 1C).
Malaria prophylaxis is strongly recommended for travelers (GoR 2C).
Antibiotic therapy should be strongly considered in the event of any sudden onset of unexplained fever, malaise, chills, or other constitutional symptoms, especially when medical review is not readily accessible (GoR 2A).
Primary care providers should be aware of the splenectomy/angioembolization (GoR 2C).
OPSI are defined as fulminant sepsis, meningitis, or pneumonia triggered mainly by Streptococcus pneumoniae (50% of cases) [204, 205] followed by H. influenzae type B and N. meningitidis. OPSI is a medical emergency. The risks of OPSI and associated death are highest in the first year after splenectomy, at least among young children, but remain elevated for more than 10 years and probably for life. The incidence of OPSI is 0.5–2%; the mortality rate is from 30 to 70%, and most death occurs within the first 24 h. Only prompt diagnosis and immediate treatment can reduce mortality [2, 204, 206, 207]. Asplenic/hyposplenic children younger than 5 years old have a greater overall risk of OPSI with an increased death compared with adults [204, 208]. The risk is more than 30% in neonates . Evidence exist regarding the possible maintaining of the function by the embolized spleen (hyposplenic patients) however is reasonable to consider it as less effective and proceed with vaccination as well [179, 189, 190].
Vaccination against flu is recommended annually for asplenic/hyposplenic patients over 6 months of age. Prevention of influenza may decrease the risk of secondary bacterial infection, including pneumococcal infection [207, 208].
Ideally, the vaccinations against S. pneumoniae, H. influenzae type B, and N. meningitidis should be given at least 2 weeks before splenectomy . Patients should be informed that immunization can only reduce the incidence of OPSI (vaccines so far available do not allow an exhaustive coverage neither for S. pneumoniae—23 of 90 serotypes are included—nor for N. meningitidis—5 of 6 serotypes) (Table 5).
In traumatic patients, the correct time for vaccination should be not less than 14 days after splenectomy; in fact, before 14 days, the antibody response is supposed to be suboptimal [204, 206, 209]; after that interval, the earlier the better. In asplenic/hyposplenic patients discharged before 15 days, where the risk to miss the vaccination is deemed high, the first vaccines should be given before discharge [206, 210]. The Centre for Disease Control in 2016 proposed the last updated recommendations . Most episodes of severe infections occur within the first 2 years after splenectomy, and for this reason, some authors recommend at least 2 years of prophylactic antibiotics after splenectomy. However, the duration of antibiotic prophylaxis is controversial.
Community physicians should be aware of the asplenic/hyposplenic condition, in order to provide them with the most appropriate level of care.
Asplenic/hyposplenic patients should be given an antibiotic supply in the event of any sudden onset of unexplained fever, malaise, chills, or other constitutional symptoms, especially when medical review is not readily accessible. The recommended options for emergency standby in adults include the following: (a) Amoxycillin, 3 g starting dose followed by 1 g, every 8 h; (b) Levofloxacin 500 mg every 24 h or Moxifloxacin 400 mg every 24 h (for beta-lactam allergic patients).
The recommended emergency standby treatment in children is Amoxycillin 50 mg/Kg in three divided daily doses. For beta-lactam allergic patients, an alternative should be proposed by a specialist (fluoroquinolones are generally contraindicated in children, but due to the possible severity of OPSI, they might still be considered).
Antibiotic prophylaxis is necessary in patients with asplenia/hyposplenia who are bitten by dogs and other animals because of increased risk of severe sepsis (Amoxycillin/Clavulanic acid for 5 days) [205, 207, 208].
If the patient is being treated in an outpatient setting, he/she should be referred immediately to the nearest emergency department. Clinical deterioration can be rapid even after antibiotic administration. Antibiotics should be modified once blood culture results become available . Failures of antibiotic prophylaxis have been reported, so patients should be warned that prophylaxis reduces but does not abolish the risk of sepsis.
Due to the increased risk of severe malaria, asplenic/hyposplenic travelers to endemic areas should receive an adequate pre-departure counseling, regarding both measures aimed at reducing the exposure to mosquitos’ bites and chemoprophylaxis.
The management of spleen trauma must be multidisciplinary and must keep into consideration the physiological and anatomical derangement together with the immunological effects. Critical and operative decisions can be taken more effectively if both anatomy of injury and its physiological effects, and the associated lesions are considered especially considering the modern tools for integrated bleeding management. The treatment algorithm must differ within adults, and children these lasts should always be treated in dedicated trauma centers.
American Association for Surgery for Trauma
Abbreviated injury score
American Pediatric Surgical Association
Advanced Trauma Life Support
Blunt spinal trauma
Diagnostic peritoneal lavage
Deep venous trombosis
Eastern Association for the Surgery of Trauma
Extended focused assessment sonography for trauma
Glasgow Coma Scale
Intensive Care Unit
Injury severity score
Level of evidence
Length of hospital stay
Massive transfusion protocols
Organ Injury Scale
Overwhelming post-splenectomy infections
Traumatic brain injury
World Society of Emergency Surgery
Oxford Centre for Evidence-based Medicine - Levels of Evidence (March 2009) - CEBM. Available from: http://www.cebm.net/oxford-centre-evidence-based-medicine-levels-evidence-march-2009/
Lynn KN, Werder GM, Callaghan RM, Sullivan AN, Jafri ZH, Bloom DA. Pediatric blunt splenic trauma: a comprehensive review. Pediatr Radiol. 2009;39:904–16.
Mutschler M, Nienaber U, Brockamp T, Wafaisade A, Fabian T, Paffrath T, et al. Renaissance of base deficit for the initial assessment of trauma patients: a base deficit-based classification for hypovolemic shock developed on data from 16,305 patients derived from the TraumaRegister DGU®. Crit Care. 2013;17:R42.
Mutschler M, Nienaber U, Münzberg M, Wölfl C, Schoechl H, Paffrath T, et al. The shock index revisited––a fast guide to transfusion requirement? A retrospective analysis on 21,853 patients derived from the TraumaRegister DGU. Crit Care. 2013;17:R172.
American College of Surgeon’s Commitee on Trauma. Advanced Trauma Life Support® (ATLS®) Student manual 9th ed.ed., American College of Surgeon, Chicago; 2012.
Da Luz LT, Nascimento B, Shankarakutty AK, Rizoli S, Adhikari NK. Effect of thromboelastography (TEG®) and rotational thromboelastometry (ROTEM®) on diagnosis of coagulopathy, transfusion guidance and mortality in trauma: descriptive systematic review. Crit Care. 2014;18:518.
Gonzalez E, Moore EE, Moore HB, Chapman MP, Chin TL, Ghasabyan A, et al. Goal-directed hemostatic resuscitation of trauma-induced coagulopathy: a pragmatic randomized clinical trial comparing a viscoelastic assay to conventional coagulation assays. Ann Surg. 2016;263:1051–9.
Kashuk JL, Moore EE, Sawyer M, Le T, Johnson J, Biffl WL, et al. Postinjury coagulopathy management: goal directed resuscitation via POC thrombelastography. Ann Surg. 2010;251:604–14.
Rossaint R, Cerny V, Coats TJ, Duranteau J, Fernández-Mondéjar E, Gordini G, et al. Key issues in advanced bleeding care in trauma. Shock. 2006;26:322–31.
Carr JA, Roiter C, Alzuhaili A. Correlation of operative and pathological injury grade with computed tomographic grade in the failed nonoperative management of blunt splenic trauma. Eur J Trauma Emerg Surg. 2012;38:433–8.
Kirkpatrick AW, Sirois M, Laupland KB, Liu D, Rowan K, Ball CG, et al. Hand-held thoracic sonography for detecting post-traumatic pneumothoraces: the extended focused assessment with sonography for trauma (EFAST). J Trauma. 2004;57:288–95.
Doody O, Lyburn D, Geoghegan T, Govender P, Monk PM, Torreggiani WC. Blunt trauma to the spleen: ultrasonographic findings. Clin Radiol. 2005;60:968–76.
El-Matbouly M, Jabbour G, El-Menyar A, Peralta R, Abdelrahman H, Zarour A, et al. Blunt splenic trauma: assessment, management and outcomes. Surgeon. 2016;14:52–8.
Soffer D, Wiesel O, Schulman CI, Ben Haim M, Klausner JM, Kessler A. Doppler ultrasound for the assessment of conservatively treated blunt splenic injuries: a prospective study. Eur J Trauma Emerg Surg. 2011;37:197–202.
Bee TK, M a C, Miller PR, Pritchard FE, Fabian TC. Failures of splenic nonoperative management: is the glass half empty or half full? J Trauma. 2001;50:230–6.
Clark R, Hird K, Misur P, Ramsay D, Mendelson R. CT grading scales for splenic injury: why can’t we agree? J Med Imaging Radiat Oncol. 2011;55:163–9.
Becker CD, Mentha G, Terrier F. Blunt abdominal trauma in adults: role of CT in the diagnosis and management of visceral injuries. Part 1: liver and spleen. Eur Radiol. 1998;8:553–62.
Shapiro MJ, Krausz C, Durham RM, Mazuski JE. Overuse of splenic scoring and computed tomographic scans. J Trauma. 1999;47:651–8.
Anderson SW, Varghese JC, Lucey BC, P a B, Hirsch EF, J a S. Blunt splenic trauma: delayed-phase CT for differentiation of active hemorrhage from contained vascular injury in patients. Radiology. 2007;243:88–95.
Jeffrey RB, Olcott EW. Imaging of blunt hepatic trauma. Radiol Clin N Am. 1991;29:1299–310.
Marmery H, Shanmuganathan K, Mirvis SE, Richard H, Sliker C, Miller LA, et al. Correlation of multidetector CT findings with splenic arteriography and surgery: prospective study in 392 patients. J Am Coll Surg. 2008;206:685–93.
Boscak AR, Shanmuganathan K, Mirvis SE, Fleiter TR, L a M, Sliker CW, et al. Optimizing trauma multidetector CT protocol for blunt splenic injury: need for arterial and portal venous phase scans. Radiology. 2013;268:79–88.
Bhullar IS, Frykberg ER, Tepas JJ, Siragusa D, Loper T, Kerwin AJ. At first blush: absence of computed tomography contrast extravasation in grade IV or V adult blunt splenic trauma should not preclude angioembolization. J Trauma Acute Care Surg. 2013;74:105-11-2.
Hassan R, Aziz AA, Ralib ARM, Saat A. Computed tomography of blunt spleen injury: a pictorial review. Malaysian J Med Sci. 2011;18:60–7.
Juyia RF, Kerr HA. Return to play after liver and spleen trauma. Sports Health. 2014;6:239–45. SAGE Publications
Fernandes TM, Dorigatti AE, Pereira BMT, Cruvinel Neto J, Zago TM, Fraga GP. Nonoperative management of splenic injury grade IV is safe using rigid protocol. Rev Col Bras Cir. 2013;40:323–9.
N a S, Bhullar I, Cheng JD, Crandall ML, Friese RS, Guillamondegui OD, et al. Selective nonoperative management of blunt splenic injury: an Eastern Association for the Surgery of Trauma practice management guideline. J Trauma Acute Care Surg. 2012;73:S294–300.
Velmahos GC, Toutouzas KG, Radin R, Chan L, Demetriades D. Nonoperative treatment of blunt injury to solid abdominal organs: a prospective study. Arch Surg. 2003;138:844–51.
Smith J, Armen S, Cook CH, Martin LC. Blunt splenic injuries: have we watched long enough? J Trauma. 2008;64:656-63-5.
Hafiz S, Desale S, Sava J. The impact of solid organ injury management on the US health care system. J Trauma Acute Care Surg. 2014;77:310–4.
Gaspar B, Negoi I, Paun S, Hostiuc S, Ganescu R, Beuran M. Selective nonoperative management of abdominal injuries in polytrauma patients: a protocol only for experienced trauma centers. Maedica. 2014;9:168–72.
Moore FA, Davis JW, Moore EE, Cocanour CS, West MA, McIntyre RC. Western Trauma Association (WTA) critical decisions in trauma: management of adult blunt splenic trauma. J Trauma. 2008;65:1007–11.
Rowell SE, Biffl WL, Brasel K, Moore EE, Albrecht RA, DeMoya M, et al. Western Trauma Association Critical Decisions in Trauma: management of adult blunt splenic trauma-2016 updates. J Trauma Acute Care Surg. 2017;82:787–93.
Peitzman AB, Harbrecht BG, Rivera L, Heil B. Failure of observation of blunt splenic injury in adults: variability in practice and adverse consequences. J Am Coll Surg. 2005;201:179–87.
Renzulli P, Gross T, Schnüriger B, Schoepfer AM, Inderbitzin D, Exadaktylos AK, et al. Management of blunt injuries to the spleen. Br J Surg. 2010;97:1696–703.
J a N, Costanza M, Daley BJ, M a P, Enderson BL. Outcome of the current management of splenic injuries. J Trauma. 2001;50:835–42.
McIntyre LK, Schiff M, Jurkovich GJ. Failure of nonoperative management of splenic injuries: causes and consequences. Arch Surg. 2005;140:563-568-569.
Ong AW, Eilertson KE, Reilly EF, Geng TA, Madbak F, McNicholas A, et al. Nonoperative management of splenic injuries: significance of age. J Surg Res. 2016;201:134–40.
Bhullar IS, Frykberg ER, Siragusa D, Chesire D, Paul J, Tepas JJ, et al. Age does not affect outcomes of nonoperative management of blunt splenic trauma. J Am Coll Surg. 2012;214:958–64.
Peitzman AB, Heil B, Rivera L, Federle M, Harbrecht BG, Clancy K, et al. Blunt splenic injury in adults: multi-institutional study of the Eastern Association for the Surgery of Trauma. J Trauma-Injury Infect Crit Care. 2000;49:177–89.
Malhotra AK, Latifi R, Fabian TC, Ivatury RR, Dhage S, Bee TK, et al. Multiplicity of solid organ injury: influence on management and outcomes after blunt abdominal trauma. J Trauma. 2003;54:925–9.
Harbrecht BG, Zenati MS, Alarcon LH, Ochoa JB, Puyana JC, Schuchert VD, et al. Is outcome after blunt splenic injury in adults better in high-volume trauma centers? Am Surg. 2005;71:942-8-9.
Cocanour CS, Moore FA, Ware DN, Marvin RG, Duke JH. Age should not be a consideration for nonoperative management of blunt splenic injury. J Trauma-Injury Infect Crit Care. 2000;48:606–12. discussion 610–612
Harbrecht BG, Peitzman AB, Rivera L, Heil B, Croce M, Morris JA, et al. Contribution of age and gender to outcome of blunt splenic injury in adults: multicenter study of the eastern association for the surgery of trauma. J Trauma. 2001;51:887–95.
Siriratsivawong K, Zenati M, Watson GA, Harbrecht BG. Nonoperative management of blunt splenic trauma in the elderly: does age play a role? Am Surg. 2007;73:585–9. discussion 590
Velmahos GC, Zacharias N, Emhoff TA, Feeney JM, Hurst JM, Crookes BA, et al. Management of the most severely injured spleen: a multicenter study of the research consortium of New England centers for trauma (ReCONECT). Arch Surg. 2010;145:456–60.
Velmahos GC, Chan LS, Kamel E, Murray JA, Yassa N, Kahaku D, et al. Nonoperative management of splenic injuries: have we gone too far? Arch Surg. 2000;135:674–81.
Jeremitsky E, Kao A, Carlton C, Rodriguez A, Ong A. Does splenic embolization and grade of splenic injury impact nonoperative management in patients sustaining blunt splenic trauma? Am Surg. 2011;77:215–20.
G a W, Rosengart MR, Zenati MS, Tsung A, Forsythe RM, Peitzman AB, et al. Nonoperative management of severe blunt splenic injury: are we getting better? J Trauma. 2006;61:1113-1118-1119.
Krause KR, Howells GA, Bair HA, Glover JL, Madrazo BL, Wasvary HJ, et al. Nonoperative management of blunt splenic injury in adults 55 years and older: a twenty-year experience. Am Surg. 2000;66:636–40.
Sartorelli KH, Frumiento C, Rogers FB, Osler TM. Nonoperative management of hepatic, splenic, and renal injuries in adults with multiple injuries. J Trauma. 2000;49:56-61-2.
Albrecht RM, Schermer CR, Morris A. Nonoperative management of blunt splenic injuries: factors influencing success in age >55 years. Am Surg. 2002;68:227-30-1.
Schurr MJ, Fabian TC, Gavant M, Croce MA, Kudsk KA, Minard G, et al. Management of blunt splenic trauma: computed tomographic contrast blush predicts failure of nonoperative management. J Trauma. 1995;39:507-512-513.
Bhangu A, Nepogodiev D, Lal N, Bowley DM. Meta-analysis of predictive factors and outcomes for failure of non-operative management of blunt splenic trauma. Injury. 2012;43:1337–46.
Aseervatham R, Muller M. Blunt trauma to the spleen. Aust N Z J Surg. 2000;70:333–7.
Crawford RS, Tabbara M, Sheridan R, Spaniolas K, Velmahos GC. Early discharge after nonoperative management for splenic injuries: increased patient risk caused by late failure? Surgery. 2007;142:337–42.
Jeremitsky E, Smith RS, Ong AW. Starting the clock: defining nonoperative management of blunt splenic injury by time. Am J Surg. 2013;205:298–301.
Chen L-Y, Shih H-C, Wu JJ, Wen Y-S, Huang M-S, Huang C-I, et al. The role of diagnostic algorithms in the management of blunt splenic injury. J Chin Med Assoc. 2005;68:373–8.
Ball CG, Kirkpatrick AW, D’Amours SK. The RAPTOR: resuscitation with angiography, percutaneous techniques and operative repair. Transforming the discipline of trauma surgery. Can J Surg. 2011;54:E3–4.
Kirkpatrick AW, Vis C, Dubé M, Biesbroek S, Ball CG, Laberge J, et al. The evolution of a purpose designed hybrid trauma operating room from the trauma service perspective: the RAPTOR (resuscitation with angiography percutaneous treatments and operative resuscitations). Injury. 2014;45:1413–21.
Fehr A, Beveridge J, SD DA, Kirkpatrick AW, Ball CG. The potential benefit of a hybrid operating environment among severely injured patients with persistent hemorrhage: how often could we get it right? J Trauma Acute Care Surg. 2016;80:457–60.
Demetriades D, Rabinowitz B. Indications for operation in abdominal stab wounds. A prospective study of 651 patients. Ann Surg. 1987;205:129–32.
Velmahos GC, Demetriades D, Toutouzas KG, Sarkisyan G, Chan LS, Ishak R, et al. Selective nonoperative management in 1,856 patients with abdominal gunshot wounds: should routine laparotomy still be the standard of care? Ann Surg. 2001:234, 395-402-403.
Renz BM, Feliciano DV. Gunshot wounds to the right thoracoabdomen: a prospective study of nonoperative management. J Trauma. 1994;37:737–44.
Inaba K, Barmparas G, Foster A, Talving P, David J-S, Green D, et al. Selective nonoperative management of torso gunshot wounds: when is it safe to discharge? J Trauma. 2010;68:1301–4.
Carlin AM, Tyburski JG, Wilson RF, Steffes C. Factors affecting the outcome of patients with splenic trauma. Am Surg. 2002;68:232–9.
Berg RJ, Inaba K, Okoye O, Pasley J, Teixeira PG, Esparza M, et al. The contemporary management of penetrating splenic injury. Injury. 2014;45:1394–400.
Haan JM, Bochicchio GV, Kramer N, Scalea TM. Nonoperative management of blunt splenic injury: a 5-year experience. J Trauma. 2005;58:492–8.
Haan J, Scott J, Boyd-Kranis RL, Ho S, Kramer M, Scalea TM. Admission angiography for blunt splenic injury: advantages and pitfalls. J Trauma. 2001;51:1161–5.
Haan JM, Biffl W, Knudson MM, Davis KA, Oka T, Majercik S, et al. Splenic embolization revisited: a multicenter review. J Trauma - Inj Infect Crit Care. 2004;56:542–7.
Tugnoli G, Bianchi E, Biscardi A, Coniglio C, Isceri S, Simonetti L, et al. Nonoperative management of blunt splenic injury in adults: there is (still) a long way to go. The results of the Bologna-Maggiore Hospital trauma center experience and development of a clinical algorithm. Surg Today. 2015;45:1210–7.
Bessoud B, Denys A, Calmes JM, Madoff D, Qanadli S, Schnyder P, et al. Nonoperative management of traumatic splenic injuries: is there a role for proximal splenic artery embolization? Am J Roentgenol. 2006;186:779–85.
Brillantino A, Iacobellis F, Robustelli U, Villamaina E, Maglione F, Colletti O, et al. Non operative management of blunt splenic trauma: a prospective evaluation of a standardized treatment protocol. Eur J Trauma Emerg Surg. 2016;42:593–8.
Smith HE, Biffl WL, Majercik SD, Jednacz J, Lambiase R, Cioffi WG. Splenic artery embolization: have we gone too far? J Trauma. 2006;61:541-544-546.
Capecci LM, Jeremitsky E, Smith RS, Philp F. Trauma centers with higher rates of angiography have a lesser incidence of splenectomy in the management of blunt splenic injury. Surgery. 2015;158:1020-4-6.
Zarzaur BL, Savage SA, Croce MA, Fabian TC. Trauma center angiography use in high-grade blunt splenic injuries: timing is everything. J Trauma Acute Care Surg. 2014;77:666–71.
Raikhlin A, Baerlocher MO, Asch MR, Myers A. Imaging and transcatheter arterial embolization for traumatic splenic injuries: review of the literature. Can J Surg. 2008;51:464–72.
Banerjee A, Duane TM, Wilson SP, Haney S, O’Neill PJ, Evans HL, et al. Trauma center variation in splenic artery embolization and spleen salvage: a multicenter analysis. J Trauma Acute Care Surg. 2013;75:69-74-5.
Rosati C, Ata A, Siskin GP, Megna D, Bonville DJ, Stain SC. Management of splenic trauma: a single institution’s 8-year experience. Am J Surg. 2015;209:308–14.
J a R, RB DA, Miller PR. Nonoperative management of adult blunt splenic injury with and without splenic artery embolotherapy: a meta-analysis. J Trauma Inj Infect Crit Care. 2011;71:898–903.
Davis KA, Fabian TC, Croce MA, Gavant ML, Flick PA, Minard G, et al. Improved success in nonoperative management of blunt splenic injuries: embolization of splenic artery pseudoaneurysms. J Trauma. 1998;44:1008-13-5.
Dehli T, Bagenholm A, Trasti NC, Monsen SA, Bartnes K, Bågenholm A, et al. The treatment of spleen injuries: a retrospective study. Scand J Trauma Resusc Emerg Med. 2015;23:85.
Shanmuganathan K, Mirvis SE, Sover ER. Value of contrast-enhanced CT in detecting active hemorrhage in patients with blunt abdominal or pelvic trauma. Am J Roentgenol. 1993;161:65–9.
Ryan M, Hamilton P, Chu P, Hanaghan J. Active extravasation of arterial contrast agent on post-traumatic abdominal computed tomography. Can Assoc Radiol J. 2004;55:160–9.
Gavant ML, Schurr M, Flick PA, Croce MA, Fabian TC, Gold RE. Predicting clinical outcome of nonsurgical management of blunt splenic injury: using CT to reveal abnormalities of splenic vasculature. Am J Roentgenol. 1997;168:207–12.
Shanmuganathan K, Mirvis SE, Boyd-Kranis R, Takada T, Scalea TM. Nonsurgical management of blunt splenic injury: use of CT criteria to select patients for splenic arteriography and potential endovascular therapy. Radiology. 2000;217:75–82.
Marmery H, Shanmuganathan K, Alexander MT, Mirvis SE. Optimization of selection for nonoperative management of blunt splenic injury: comparison of MDCT grading systems. Am J Roentgenol. 2007;189:1421–7.
Fu C-Y, Wu S-C, Chen R-J, Chen Y-F, Wang Y-C, Huang H-C, et al. Evaluation of need for operative intervention in blunt splenic injury: intraperitoneal contrast extravasation has an increased probability of requiring operative intervention. World J Surg. 2010;34:2745–51.
Yuan K-C, Wong Y-C, Lin B-C, Kang S-C, Liu E-H, Hsu Y-P. Negative catheter angiography after vascular contrast extravasations on computed tomography in blunt torso trauma: an experience review of a clinical dilemma. Scand J Trauma Resusc Emerg Med. 2012;20:46.
Alarhayem AQ, Myers JG, Dent D, Lamus D, Lopera J, Liao L, et al. “blush at first sight”: significance of computed tomographic and angiographic discrepancy in patients with blunt abdominal trauma. Am J Surg. 2015;210:1104-10-1.
Skattum J, Naess PA, Eken T, Gaarder C. Refining the role of splenic angiographic embolization in high-grade splenic injuries. J Trauma Acute Care Surg. 2013;74:100-3-4.
Miller PR, Chang MC, Hoth JJ, Mowery NT, Hildreth AN, Martin RS, et al. Prospective trial of angiography and embolization for all grade III to V blunt splenic injuries: nonoperative management success rate is significantly improved. J Am Coll Surg. 2014;218:644–8.
Chastang L, Bège T, Prudhomme M, Simonnet AC, Herrero A, Guillon F, et al. Is non-operative management of severe blunt splenic injury safer than embolization or surgery? Results from a French prospective multicenter study. J Visc Surg. 2015;152:85–91.
Frandon J, Rodière M, Arvieux C, Michoud M, Vendrell A, Broux C, et al. Blunt splenic injury: outcomes of proximal versus distal and combined splenic artery embolization. Diagn Interv Imaging. 2014;95:825–31.
Schnüriger B, Inaba K, Konstantinidis A, Lustenberger T, Chan LS, Demetriades D. Outcomes of proximal versus distal splenic artery embolization after trauma: a systematic review and meta-analysis. J Trauma. 2011;70:252–60.
Ekeh AP, McCarthy MC, Woods RJ, Haley E. Complications arising from splenic embolization after blunt splenic trauma. Am J Surg. 2005;189:335–9.
Frandon J, Rodiere M, Arvieux C, Vendrell A, Boussat B, Sengel C, et al. Blunt splenic injury: are early adverse events related to trauma, nonoperative management, or surgery? Diagnostic Interv Radiol. 2015;21:327–33.
Demetriades D, Scalea TM, Degiannis E, Barmparas G, Konstantinidis A, Massahis J, et al. Blunt splenic trauma: splenectomy increases early infectious complications: a prospective multicenter study. J Trauma Acute Care Surg. 2012;72:229–34.
Kaseje N, Agarwal S, Burch M, Glantz A, Emhoff T, Burke P, et al. Short-term outcomes of splenectomy avoidance in trauma patients. Am J Surg. 2008;196:213–7.
Freitas G, Olufajo OA, Hammouda K, Lin E, Cooper Z, Havens JM, et al. Postdischarge complications following nonoperative management of blunt splenic injury. Am J Surg. 2016;211:744–9.
Wei B, Hemmila MR, Arbabi S, Taheri PA, Wahl WL, et al. Angioembolization reduces operative intervention for blunt splenic injury. J Trauma - Inj Infect Crit Care. 2008;64:1472–7.
Ekeh AP, Khalaf S, Ilyas S, Kauffman S, Walusimbi M, McCarthy MC. Complications arising from splenic artery embolization: a review of an 11-year experience. Am J Surg. 2013;205:250–4.
Wu SC, Chen RJ, Yang AD, Tung CC, Lee KH. Complications associated with embolization in the treatment of blunt splenic injury. World J Surg. 2008;32:476–82.
Bruce PJP, Helmer SD, Harrison PB, Sirico T, Haan JM. Nonsurgical management of blunt splenic injury: is it cost effective? Am J Surg. 2011;202:810–6.
Morrell DG, Chang FC, Helmer SD. Changing trends in the management of splenic injury. Am J Surg. 1995;170:686–9. discussion 690
Carter JW, Falco MH, Chopko MS, Flynn WJ, Wiles Iii CE, Guo WA. Do we really rely on fast for decision-making in the management of blunt abdominal trauma? Injury. 2015;46:817–21.
Hady HR, Łuba M, Myśliwiec P, Trochimowicz L, Łukaszewicz J, Zurawska J, et al. Surgical management in parenchymatous organ injuries due to blunt and penetrating abdominal traumas––the authors’ experience. Adv Clin Exp Med. 2012;21:193–200.
Garber BG, Yelle JD, Fairfull-Smith R, Lorimer JW, Carson C. Management of splenic injuries in a Canadian trauma centre. Can J Surg. 1996;39:474–80.
Haddad SH, Yousef ZM, Al-Azzam SS, Aldawood AS, Al-Zahrani AA, Alzamel HA, et al. Profile, outcome and predictors of mortality of abdomino-pelvic trauma patients in a tertiary intensive care unit in Saudi Arabia. Injury. 2015;46:94–9.
Swaid F, Peleg K, Alfici R, Matter I, Olsha O, Ashkenazi I, et al. Concomitant hollow viscus injuries in patients with blunt hepatic and splenic injuries: an analysis of a National Trauma Registry database. Injury. 2014;45:1409–12.
Garber BG, Mmath BP, Fairfull-Smith RJ, Yelle JD. Management of adult splenic injuries in Ontario: a population-based study. Can J Surg. 2000;43:283–8.
Nasr WI, Collins CL, Kelly JJ. Feasibility of laparoscopic splenectomy in stable blunt trauma: a case series. J Trauma. 2004;57:887–9.
Hallfeldt KK, Trupka AW, Erhard J, Waldner H, Schweiberer L. Emergency laparoscopy for abdominal stab wounds. Surg Endosc. 1998;12:907–10.
Pisters PW, Pachter HL. Autologous splenic transplantation for splenic trauma. Ann Surg. 1994;219:225–35.
Qu Y, Ren S, Li C, Qian S, Liu P. Management of postoperative complications following splenectomy. Int Surg. 2013;98:55–60.
Alabbasi T, Nathens AB, Tien H. Blunt splenic injury and severe brain injury: a decision analysis and implications for care. Can J Surg. 2015;58:S108–17.
Rostas JW, Manley J, Gonzalez RP, Brevard SB, Ahmed N, Frotan MA, et al. The safety of low molecular-weight heparin after blunt liver and spleen injuries. Am J Surg. 2015;210:31–4.
Murphy PB, Sothilingam N, Charyk Stewart T, Batey B, Moffat B, Gray DK, et al. Very early initiation of chemical venous thromboembolism prophylaxis after blunt solid organ injury is safe. Can J Surg. 2016;59:118–22.
Alejandro KV, Acosta JA, Rodríguez PA. Bleeding manifestations after early use of low-molecular-weight heparins in blunt splenic injuries. Am Surg. 2003;69:1006–9.
Zarzaur BL, R a K, Fabian TC, Coimbra R. A survey of American Association for the Surgery of Trauma member practices in the management of blunt splenic injury. J Trauma. 2011;70:1026–31.
Eberle BM, Schnüriger B, Inaba K, Cestero R, Kobayashi L, Barmparas G, et al. Thromboembolic prophylaxis with low-molecular-weight heparin in patients with blunt solid abdominal organ injuries undergoing nonoperative management: current practice and outcomes. J Trauma. 2011;70:141–6. discussion 147
Joseph B, Pandit V, Harrison C, Lubin D, Kulvatunyou N, Zangbar B, et al. Early thromboembolic prophylaxis in patients with blunt solid abdominal organ injuries undergoing nonoperative management: is it safe? Am J Surg. 2015;209:194–8.
Weinberger J, Cipolle M. Optimal reversal of novel anticoagulants in trauma. Crit Care Clin. 2017;33:135–52.
Imbert P, Rapp C, Buffet PA. Pathological rupture of the spleen in malaria: analysis of 55 cases (1958–2008). Travel Med Infect Dis. 2009;7:147–59.
Clancy AA, Tiruta C, Ashman D, Ball CG, Kirkpatrick AW. The song remains the same although the instruments are changing: complications following selective non-operative management of blunt spleen trauma: a retrospective review of patients at a level I trauma centre from 1996 to 2007. J Trauma Manag Outcomes. 2012;6:4.
Gannon EH, Howard T. Splenic injuries in athletes: a review. Curr Sports Med Rep. 2010;9:111–4.
Frumiento C, Sartorelli K, Vane D. Complications of splenic injuries: expansion of the nonoperative theorem. J Pediatr Surg. 2000;35:788–91.
Zarzaur BL, Vashi S, Magnotti LJ, Croce MA, Fabian TC. The real risk of splenectomy after discharge home following nonoperative management of blunt splenic injury. J Trauma. 2009;66:1531–8.
S a S, Zarzaur BL, Magnotti LJ, J a W, Maish GO, Bee TK, et al. The evolution of blunt splenic injury: resolution and progression. J Trauma. 2008;64:1085-91-2.
Meguid AA, Bair HA, Howells GA, Bendick PJ, Kerr HH, Villalba MR. Prospective evaluation of criteria for the nonoperative management of blunt splenic trauma. Am Surg. 2003;69:238-42-3.
Riezzo I, Di Battista B, De Salvia A, Cantatore S, Neri M, Pomara C, et al. Delayed splenic rupture: dating the sub-capsular hemorrhage as a useful task to evaluate causal relationships with trauma. Forensic Sci Int. 2014;234:64–71.
Haan JM, Boswell S, Stein D, Scalea TM. Follow-up abdominal CT is not necessary in low-grade splenic injury. Am Surg. 2007;73:13–8.
Muroya T, Ogura H, Shimizu K, Tasaki O, Kuwagata Y, Fuse T, et al. Delayed formation of splenic pseudoaneurysm following nonoperative management in blunt splenic injury: multi-institutional study in Osaka, Japan. J Trauma Acute Care Surg. 2013;75:417–20.
Uecker J, Pickett C, Dunn E. The role of follow-up radiographic studies in nonoperative management of spleen trauma. Am Surg. 2001;67:22–5.
Lyass S, Sela T, Lebensart PD, Muggia-Sullam M. Follow-up imaging studies of blunt splenic injury: do they influence management? Isr Med Assoc J. 2001;3:731–3.
Lynch JM, Meza MP, Newman B, Gardner MJ, Albanese CT. Computed tomography grade of splenic injury is predictive of the time required for radiographic healing. J Pediatr Surg. 1997;32:1093–6.
Unal E, Onur MR, Akpinar E, Ahmadov J, Karcaaltincaba M, Ozmen MN, et al. Imaging findings of splenic emergencies: a pictorial review. Insights Imaging. 2016;7:215–22.
Linet MS, Nyrén O, Gridley G, Adami HO, Buckland JD, McLaughlin JK, et al. Causes of death among patients surviving at least one year following splenectomy. Am J Surg. 1996;172:320–3.
Bairdain S, Litman HJ, Troy M, McMahon M, Almodovar H, Zurakowski D, et al. Twenty-years of splenic preservation at a level 1 pediatric trauma center. J Pediatr Surg. 2015;50:864–8.
Alonso M, Brathwaite C, García V, Patterson L, Scherer T, Stafford P, et al. Practice management guidelines for the nonoperative management of blunt injury to the liver and spleen. Chicago: Eastern Association for the Surgery of Trauma; 2003.
Moore EE, Cogbill TH, Jurkovich GJ, Shackford SR, Malangoni MA, Champion HR. Organ injury scaling: spleen and liver (1994 revision). J Trauma. 1995;38:323–4.
Stylianos S. Evidence-based guidelines for resource utilization in children with isolated spleen or liver injury. The APSA Trauma Committee. J Pediatr Surg. 2000;35:164–9.
McVay MR, Kokoska ER, Jackson RJ, Smith SD. Throwing out the “grade” book: management of isolated spleen and liver injury based on hemodynamic status. J Pediatr Surg. 2008;43:1072–6.
Martin K, Vanhouwelingen L, Bütter A. The significance of pseudoaneurysms in the nonoperative management of pediatric blunt splenic trauma. J Pediatr Surg. 2011;46:933–7.
Li D, Yanchar N. Management of pediatric blunt splenic injuries in Canada-practices and opinions. J Pediatr Surg. 2009;44:997–1004.
Bond SJ, Eichelberger MR, Gotschall CS, Sivit CJ, Randolph JG. Nonoperative management of blunt hepatic and splenic injury in children. Ann Surg. 1996;223:286–9.
Muehrcke DD, Kim SH, McCabe CJ. Pediatric splenic trauma: predicting the success of nonoperative therapy. Am J Emerg Med. 1987;5:109–12.
Delius RE, Frankel W, Coran AG. A comparison between operative and nonoperative management of blunt injuries to the liver and spleen in adult and pediatric patients. Surgery. 1989;106:788-92-3.
Lynch JM, Ford H, Gardner MJ, Weiner ES. Is early discharge following isolated splenic injury in the hemodynamically stable child possible? J Pediatr Surg. 1993;28:1403–7.
Konstantakos AK, Barnoski AL, Plaisier BR, Yowler CJ, Fallon WF, Malangoni MA. Optimizing the management of blunt splenic injury in adults and children. Surgery. 1999;126:805–13.
Upadhyaya P. Conservative management of splenic trauma: history and current trends. Pediatr Surg Int. 2003;19:617–27.
Rodrigues CJ, Sacchetti JC, Rodrigues AJ. Age-related changes in the elastic fiber network of the human splenic capsule. Lymphology. 1999;32:64–9.
Notrica DM, Eubanks JW, Tuggle DW, Maxson RT, Letton RW, Garcia NM, et al. Nonoperative management of blunt liver and spleen injury in children: evaluation of the ATOMAC guideline using GRADE. J Trauma Acute Care Surg. 2015;79:683–93.
Singer G, Rieder S, Eberl R, Wegmann H, Hoellwarth ME. Comparison of two treatment eras and sonographic long-term outcome of blunt splenic injuries in children. Eur J Pediatr. 2013;172:1187–90.
Durkin N, Deganello A, Sellars ME, Sidhu PS, Davenport M, Makin E. Post-traumatic liver and splenic pseudoaneurysms in children: diagnosis, management, and follow-up screening using contrast enhanced ultrasound (CEUS). J Pediatr Surg. 2016;51:289–92.
Menaker J, Blumberg S, Wisner DH, Dayan PS, Tunik M, Garcia M, et al. Use of the focused assessment with sonography for trauma (FAST) examination and its impact on abdominal computed tomography use in hemodynamically stable children with blunt torso trauma. J Trauma Acute Care Surg. 2014;77:427–32.
Murphy R, Ghosh A. Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. The accuracy of abdominal ultrasound in paediatric trauma. Emerg Med J. 2001;18:208–9.
Scaife ER, Rollins MD, Barnhart DC, Downey EC, Black RE, Meyers RL, et al. The role of focused abdominal sonography for trauma (FAST) in pediatric trauma evaluation. J Pediatr Surg. 2013;48:1377–83.
Holmes JF, Gladman A, Chang CH. Performance of abdominal ultrasonography in pediatric blunt trauma patients: a meta-analysis. J Pediatr Surg. 2007;42:1588–94.
Zabolotny B, Hancock BJ, Postuma R, Wiseman N. Blunt splenic injuries in a Canadian pediatric population: the need for a management guideline. Can J Surg. 2002;45:358–62.
Stylianos S, Pearl R. Abdominal Trauma. In: Grosfeld JL, O’Neill J, Coran A, Fonkalsrud E, Caldamone A, editors. Pediatr Surg. 6th ed. Philadelphia: Mosby; 2006. p. 295–316.
Leinwand MJ, Atkinson CC, Mooney DP, Groner J, Lund D. Application of the APSA evidence-based guidelines for isolated liver or spleen injuries: a single institution experience. J Pediatr Surg. 2004;39:487–90.
Gutierrez IM, Zurakowski D, Chen Q, Mooney DP. Clinical practice guidelines (CPGs) reduce costs in the management of isolated splenic injuries at pediatric trauma centers. Langenbeck's Arch Surg. 2013;398:313–5.
Cloutier DR, Baird TB, Gormley P, McCarten KM, Bussey JG, Luks FI. Pediatric splenic injuries with a contrast blush: successful nonoperative management without angiography and embolization. J Pediatr Surg. 2004;39:969–71.
Al-Shanafey S, Giacomantonio M, Jackson R. Splenic injuries in children: correlation between imaging and clinical management. Pediatr Surg Int. 2001;17:365–8.
Ruess L, Sivit CJ, Eichelberger MR, Taylor GA, Bond SJ. Blunt hepatic and splenic trauma in children: correlation of a CT injury severity scale with clinical outcome. Pediatr Radiol. 1995;25:321–5.
Nance ML, Mahboubi S, Wickstrom M, Prendergast F, Stafford PW. Pattern of abdominal free fluid following isolated blunt spleen or liver injury in the pediatric patient. J Trauma. 2002;52:85–7.
Murphy EE, Murphy SG, Cipolle MD, Tinkoff GH. The pediatric trauma center and the inclusive trauma system: impact on splenectomy rates. J Trauma Acute Care Surg. 2015;78:930–4.
Sims CA, Wiebe DJ, Nance ML. Blunt solid organ injury: do adult and pediatric surgeons treat children differently? J Trauma. 2008;65:698–703.
Stylianos S, Egorova N, Guice KS, Arons RR, Oldham KT. Variation in treatment of pediatric spleen injury at trauma centers versus nontrauma centers: a call for dissemination of American Pediatric Surgical Association benchmarks and guidelines. J Am Coll Surg. 2006;202:247–51.
Mooney DP, Rothstein DH, Forbes PW. Variation in the management of pediatric splenic injuries in the United States. J Trauma Inj Infect Crit Care. 2006;61:330–3.
Mooney DP, Forbes PW. Variation in the management of pediatric splenic injuries in New England. J Trauma. 2004;56:328–33.
Todd SR, Arthur M, Newgard C, Hedges JR, Mullins RJ. Hospital factors associated with splenectomy for splenic injury: a national perspective. J Trauma. 2004;57:1065–71.
Holmes JH 4th, Wiebe DJ, Tataria M, Mattix KD, Mooney DP, Scaife ER, et al. The failure of nonoperative management in pediatric solid organ injury: a multi-institutional experience. J Trauma. 2005;59:1309–13.
Sharma OP, Oswanski MF, Singer D, Raj SS, Daoud YAH. Assessment of nonoperative management of blunt spleen and liver trauma. Am Surg. 2005;71:379–86.
Narci A, Solak O, Turhan-Haktanir N, Ayçiçek A, Demir Y, Ela Y, et al. The prognostic importance of trauma scoring systems in pediatric patients. Pediatr Surg Int. 2009;25:25–30.
Richards JR, McGahan JP, Jones CD, Zhan S, Gerscovich EO. Ultrasound detection of blunt splenic injury. Injury. 2001;32:95–103.
Tataria M, Nance ML, Holmes JH 4th, Miller CC 3rd, Mattix KD, Brown RL, et al. Pediatric blunt abdominal injury: age is irrelevant and delayed operation is not detrimental. J Trauma. 2007;63:608–14.
Gross JL, Woll NL, Hanson CA, Pohl C, Scorpio RJ, Kennedy AP Jr, et al. Embolization for pediatric blunt splenic injury is an alternative to splenectomy when observation fails. J Trauma Acute Care Surg. 2013;75:421–5.
Kiankhooy A, Sartorelli KH, Vane DW, Bhave AD. Angiographic embolization is safe and effective therapy for blunt abdominal solid organ injury in children. J Trauma. 2010;68:526–31.
Bansal S, Karrer FM, Hansen K, Partrick DA. Contrast blush in pediatric blunt splenic trauma does not warrant the routine use of angiography and embolization. Am J Surg. 2015;210:345–50.
Nance ML. Abdominal trauma. Fundam Pediatr Surg. New York: Springer New York; 2011. p. 135–43.
Yardeni D, Polley TZJ, Coran AG. Splenic artery embolization for post-traumatic splenic artery pseudoaneurysm in children. J Trauma. 2004;57:404–7.
Skattum J, Gaarder C, Naess PA. Splenic artery embolisation in children and adolescents—an 8 year experience. Injury. 2014;45:160–3.
Mayglothling JA, Haan JM, Scalea TM. Blunt splenic injuries in the adolescent trauma population: the role of angiography and embolization. J Emerg Med. 2011;41:21–8.
Schuster T, Leissner G. Selective angioembolization in blunt solid organ injury in children and adolescents: review of recent literature and own experiences. Eur J Pediatr Surg. 2013;23:454–63.
van der Vlies CH, Saltzherr TP, Wilde JCH, van Delden OM, de Haan RJ, Goslings JC. The failure rate of nonoperative management in children with splenic or liver injury with contrast blush on computed tomography: a systematic review. J Pediatr Surg. 2010;45:1044–9.
Ben-Ishay O, Gutierrez IM, Pennington EC, Mooney DP. Transarterial embolization in children with blunt splenic injury results in postembolization syndrome: a matched case-control study. J Trauma Acute Care Surg. 2012;73:1558–63.
Skattum J, Loekke RJV, Titze TL, Bechensteen AG, Aaberge IS, Osnes LT, et al. Preserved function after angioembolisation of splenic injury in children and adolescents: a case control study. Injury. 2014;45:156–9.
Schimmer JAG, Van Der Steeg AFW, Zuidema WP. Splenic function after angioembolization for splenic trauma in children and adults: a systematic review. Injury. 2016;47:525–30.
Akinkuolie AA, Lawal OO, Arowolo OA, Agbakwuru EA, Adesunkanmi ARK. Determinants of splenectomy in splenic injuries following blunt abdominal trauma. South African J Surg. 2010;48:15–9.
Polites SF, Zielinski MD, Zarroug AE, Wagie AE, Stylianos S, Habermann EB. Benchmarks for splenectomy in pediatric trauma: how are we doing? J Pediatr Surg. 2015;50:339–42.
Nwomeh BC, Nadler EP, Meza MP, Bron K, B a G, Ford HR. Contrast extravasation predicts the need for operative intervention in children with blunt splenic trauma. J Trauma. 2004;56:537–41.
Jen HC, Tillou A, Cryer HG, Shew SB. Disparity in management and long-term outcomes of pediatric splenic injury in California. Ann Surg. 2010;251:1162–6.
Mohamed AA, Mahran KM, Zaazou MM. Blunt abdominal trauma requiring laparotomy in polytraumatized patients. Saudi Med J. 2010;31:43–8.
Lo A, Matheson A-M, Adams D. Impact of concomitant trauma in the management of blunt splenic injuries. N Z Med J. 2004;117:U1052.
Resende V, Petroianu A. Functions of the splenic remnant after subtotal splenectomy for treatment of severe splenic injuries. Am J Surg. 2003;185:311–5.
Keller MS, Sartorelli KH, Vane DW. Associated head injury should not prevent nonoperative management of spleen or liver injury in children. J Trauma. 1996;41:471–5.
St Peter SD, Aguayo P, Juang D, Sharp SW, Snyder CL, Holcomb GW, et al. Follow up of prospective validation of an abbreviated bedrest protocol in the management of blunt spleen and liver injury in children. J Pediatr Surg. 2013;48:2437–41.
Minarik L, Slim M, Rachlin S, Brudnicki A. Diagnostic imaging in the follow-up of nonoperative management of splenic trauma in children. Pediatr Surg Int. 2002;18:429–31.
Huebner S, Reed MH. Analysis of the value of imaging as part of the follow-up of splenic injury in children. Pediatr Radiol. 2001;31(12):852–5.
Pachter HL, Guth AA, Hofstetter SR, Spencer FC. Changing patterns in the management of splenic trauma: the impact of nonoperative management. Ann Surg. 1998;227:708–9.
Moore HB, Vane DW. Long-term follow-up of children with nonoperative management of blunt splenic trauma. J Trauma. 2010;68:522–5.
Leone G, Pizzigallo E. Bacterial infections following splenectomy for malignant and nonmalignant hematologic diseases. Mediterr J Hematol Infect Dis. 2015;7
Skattum J, P a N, Gaarder C. Non-operative management and immune function after splenic injury. Br J Surg. 2012;99 Suppl 1:59–65.
Shatz DV. Vaccination practices among North American trauma surgeons in splenectomy for trauma. J Trauma. 2002;53:950–6.
Spelman D, Buttery J, Daley A, Isaacs D, Jennens I, Kakakios A, et al. Guidelines for the prevention of sepsis in asplenic and hyposplenic patients. Intern Med J. 2008;38:349–56.
Salvadori MI, Price VE. Preventing and treating infections in children with asplenia or hyposplenia. Paediatr Child Heal. 2014;19:271–4.
Programme Funded Pre Post Splenectomy, Immunisation Advisory Center. University of Auckland. Auckland, New Zealand http://www.immune.org.nz/sites/default/files/ProgrammeAspleniaImac20160331V01Final_0.pdf.
Shatz DV, Romero-Steiner S, Elie CM, Holder PF, Carlone GM. Antibody responses in postsplenectomy trauma patients receiving the 23-valent pneumococcal polysaccharide vaccine at 14 versus 28 days postoperatively. J Trauma. 2002;53:1037–42.
ACIP Vaccine Recommendations. Centers for disease control and prevention, recommended immunization schedules, 2016.
Special thanks to Ms. Franca Boschini (Bibliographer, Medical Library, Papa Giovanni XXIII Hospital, Bergamo, Italy) for the precious bibliographical work.
FC, GM, FCa, YK, WB, EEM, VR, CB, MB, PF, HB, IM, GV, RI, KS, TH, RB, BMP, GPF, KI, JK, NP, KSM, PTM, AK, FAZ, CAG, SVB, NN, FS, SM, MS, VA, EG, LS, AC, AC, MT, VK, CA, LN, LH, MP, SM, DAS, MM, KAD, NDA, AL, PF, RL, DCN, YO, RC, RVM, FM, SR, BS, JMG, OC, SC, ACM, DW, MC, AH, ABP, LW, MS, SDS, and LA contributed to manuscript conception and draft, critically revised the manuscript, contributed important scientific knowledge, and gave final approval of the manuscript.
There is no funding received in this study.
Availability of data and materials
Ethics approval and consent to participate
Consent for publication
The authors declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Coccolini, F., Montori, G., Catena, F. et al. Splenic trauma: WSES classification and guidelines for adult and pediatric patients. World J Emerg Surg 12, 40 (2017). https://doi.org/10.1186/s13017-017-0151-4