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Emergency angiography for trauma patients and potential association with acute kidney injury

Abstract

Background

Angiography has been conducted as a hemostatic procedure for trauma patients. While several complications, such as tissue necrosis after embolization, have been reported, little is known regarding subsequent acute kidney injury (AKI) due to contrast media. To elucidate whether emergency angiography would introduce kidney dysfunction in trauma victims, we compared the incidence of AKI between patients who underwent emergency angiography and those who did not.

Methods

A retrospective cohort study was conducted using a nationwide trauma database (2004–2019), and adult trauma patients were included. The indication of emergency angiography was determined by both trauma surgeons and radiologists, and AKI was diagnosed by treating physicians based on a rise in serum creatinine and/or fall in urine output according to any published standard criteria. Incidence of AKI was compared between patients who underwent emergency angiography and those who did not. Propensity score matching was conducted to adjust baseline characteristics including age, comorbidities, mechanism of injury, vital signs on admission, Injury Severity Scale (ISS), degree of traumatic kidney injury, surgical procedures, and surgery on the kidney, such as nephrectomy and nephrorrhaphy.

Results

Among 230,776 patients eligible for the study, 14,180 underwent emergency angiography. The abdomen/pelvis was major site for angiography (10,624 [83.5%]). Embolization was performed in 5,541 (43.5%). Propensity score matching selected 12,724 pairs of severely injured patients (median age, 59; median ISS, 25). While the incidence of AKI was rare, it was higher among patients who underwent emergency angiography than in those who did not (140 [1.1%] vs. 67 [0.5%]; odds ratio = 2.10 [1.57–2.82]; p < 0.01). The association between emergency angiography and subsequent AKI was observed regardless of vasopressor usage or injury severity in subgroup analyses.

Conclusions

Emergency angiography in trauma patients was probably associated with increased incidence of AKI. The results should be validated in future studies.

Background

Angiography has been conducted as a hemostatic or diagnostic procedure for trauma patients for several decades, and indications for angiography after injury continue to expand [1, 2]. While surgery is the standard treatment for patients with bleeding, angiography with embolization to control arterial hemorrhage has been performed as a less invasive procedure [1, 3, 4]. Notably, the success rate of non-operative management for patients with high-grade splenic injury has been reported to be improved to 95% after emergency angiography with embolization [5, 6].

While several complications of angiography including tissue necrosis, re-bleeding, and vascular injury [7, 8] have been reported, little is known regarding subsequent kidney injury due to contrast media that is used in angiography for trauma victims. Acute kidney injury (AKI) following intravascular administration of contrast media is defined by several terms such as contrast-induced nephropathy (CIN), contrast-induced AKI (CI-AKI), or post-contrast AKI (PC-AKI) [9, 10], and nearly 10% of patients who were given considerable amount of contrast media in percutaneous coronary angiography were found to develop PC-AKI [11]. Conversely, a recent systematic review identified that a relatively small amount of contrast media, such as the amount administered in a contrast-enhanced CT scan, was not associated with newly developed AKI unless baseline kidney function was severely compromised [12]. Since the dosage of contrast media administered during emergency angiography for trauma patients is often higher than the amount given for a CT with contrast [13], risks of angiography on kidney function exist, and this potential effect has not been extensively examined among severely injured patients. It should be also emphasized that some trauma patients who undergo angiography are likely at higher risk for AKI due to hemodynamic instability and direct traumatic insult to the kidney [14, 15].

Accordingly, to eventually ascertain whether emergency angiography might independently introduce subsequent AKI among trauma patients, we used a nationwide trauma database to compare the incidence of AKI between patients who underwent emergency angiography and those who did not. We hypothesized that emergency angiography would be independently associated with higher incidence of AKI in severely injured trauma patients.

Methods

Study design and setting

We conducted a retrospective cohort study using data from the Japan Trauma Data Bank (JTDB). The JTDB was established as a Japanese nationwide trauma registry in 2003, representing > 250 participating hospitals and tertiary care centers. Before initiating the study, all collaborating hospitals obtained individual local institutional review board approval for conducting research with human subjects [16].

Current practice in Japan recommends consideration for emergency angiography in hemodynamically stable trauma patients who have evidence of bleeding or severe organ injury diagnosed with contrast-enhanced CT scan. The decision to perform emergency angiography is determined by discussion between trauma surgeons and radiologists based on CT scan findings and patient status. However, as trauma surgeons are not always present in the hospital, emergency physicians sometimes independently decide emergency angiography.

Study population

We retrospectively reviewed data from the JTDB between January 2004 and March 2019. Trauma patients who were aged ≥ 18 years and were transported directly from the scene were included. Patients who arrived with cardiac arrest and those with missing data on the emergency angiography were excluded.

Data collection and definitions

Available data included age, sex, mechanism of injury, comorbidities, vital signs on hospital arrival, Abbreviated Injury Scale (AIS) score, Injury Severity Score (ISS), presence of compartment syndrome in extremities, vasopressor usage, and any surgical procedures including laparotomy, thoracotomy, resuscitative thoracotomy (RT), and resuscitative endovascular balloon occlusion of the aorta (REBOA). Procedures performed related to traumatic kidney injury such as total nephrectomy, partial nephrectomy, and nephrorrhaphy were also available. The target regions for angiography and concomitant embolization were recorded in the database, but details regarding the indications for angiography or the hemodynamic status during angiography were not available.

Emergency angiography was recorded when an angiography was urgently performed as a hemostatic or diagnostic procedure during the initial resuscitation, regardless of preceding hemostatic surgery or time interval between hospital arrival and initiation of the angiography. Any scheduled or unscheduled angiographic procedures which were conducted after the achievement of initial resuscitation with hemostasis (e.g., angiography for re-bleeding or pseudoaneurysm found later), were not recorded as emergency angiography.

AKI was diagnosed by treating physicians based on a rise in serum creatinine and/or fall in urine output according to any published standard criteria depending on the time of study inclusion. Predefined uniform criteria for AKI were not used in the database. Serum creatine values, urine output, and hemodialysis requirement were not available in the database.

Outcome measures

The primary outcome was the incidence of AKI prior to discharge. Secondary outcomes included hospital-free days and intensive care unit (ICU)-free days until day 30.

Statistical analysis

Patient data were divided between angiography and non-angiography groups. The angiography group consisted of patients who underwent emergency angiography, while the non-angiography group consisted of those who were treated without emergency angiography. Unadjusted analysis was performed on the primary outcome with Chi-square test.

To select a similar cohort of control patients from the non-angiography group, propensity score matching was performed [17]. The propensity score was developed using a logistic regression model to estimate the probability of being assigned to the angiography group [18]. Relevant covariates were selected from known or possible indications for angiography and background risks for kidney injury, including baseline characteristics such as age, sex, comorbidities, mechanism of injury, vital signs on admission, abdominal AIS, renal AIS, ISS, surgical procedures, and the type of surgery on the kidney [9, 10, 13,14,15, 19]. Patients with missing covariates were excluded from propensity score calculation. The precision of discrimination of propensity score was analyzed with the c-statistic. One-to-one propensity score matching was then performed using a greedy matching algorithm without replacement, where a caliper width of less than 0.2 of the standard deviation of logit-transformed propensity score was applied. Equality of patient characteristics between both groups after matching was evaluated with the standardized difference of each covariate, in which standardized difference < 0.1 was considered as non-biased distribution [18, 20]. The inter-group comparison of primary and secondary outcomes after propensity score matching was performed using Chi-square tests or ordinal regression analysis, as appropriate.

An inverse probability weighting analysis using propensity score and a logistic regression analysis with propensity score as covariate were conducted as sensitivity analyses on the whole population [17, 21]. Furthermore, the primary outcome was compared between the angiography and non-angiography groups in the subgroup of patients who were divided based on the presence of chronic kidney disease (CKD) before injury, age (≥ 65 vs < 65 years), severity of injury (ISS ≥ 25 vs < 25), vasopressor usage, and the year of injury (2004–2009 vs 2010–2019).

Descriptive statistics are presented as the median (interquartile range) or number (percentage). Results are shown using standardized difference and 95% confidence interval (CI). Missing/ambiguous values were used without manipulation. Testing of the hypothesis was only performed on the primary outcome, in which a 2-sided α threshold of 0.05 was considered statistically significant. All statistical analyses were conducted using SPSS, version 26.0 (IBM, Armonk, NY), and Microsoft Excel (Microsoft, Redmond, WA).

Results

Patient characteristics

Among 361,706 trauma patients in the database, 331,709 adult patients were transported directly from the scene, and 230,776 patients were eligible for this study (Fig. 1). A total of 14,180 (6.1%) patients underwent an emergency angiography.

Fig. 1
figure1

Patient flow diagram. Among 361,706 trauma patients in the database, 331,709 adult patients were transported directly from the scene, and 230,776 patients were eligible for this study. A total of 14,180 (6.1%) patients underwent an emergency angiography. Among the 14,180 patients in the angiography group, 12,724 patients were matched with controls in the non-angiography group

Patient characteristics are summarized in Table 1. Patients in the angiography group were younger and had lower Glasgow Coma Scale (GCS) and lower systolic blood pressures (sBP) on arrival compared with those in the non-angiography group, as well as higher ISS (25 [16–35] vs. 10 [9–18]). Furthermore, more patients in the angiography group underwent surgical procedures than those in the non-angiography group, including total nephrectomy (43 [0.3%] vs. 100 [0.0%]). Vasopressors were used more in the angiography group than in the non-angiography group. Target regions for emergency angiography are shown in Table 2. The abdomen/pelvis was the major site for angiography (10,624 [83.5%]), and embolization was performed in 5,541 (43.5%) patients.

Table 1 Characteristics of patients with or without angiography
Table 2 Details of angiography

The propensity model was validated with 0.818 of c-statistic. Among the 14,180 patients in the angiography group, 12,724 patients were matched with controls in the non-angiography group. Patient characteristics after matching are summarized in Table 1. In the matched population, background characteristics of patients in the two groups became comparable (standardized differences were < 0.1 in all covariates after matching).

Incidence of AKI and secondary outcomes

Unadjusted analysis identified that the incidence of AKI was significantly higher among patients who underwent emergency angiography compared to those who did not (160 [1.1%] vs. 537 [0.2%]; odds ratio [OR], 4.59; 95% confidence interval [CI], 3.85–5.48; p < 0.001; Table 3), and propensity score matching analysis revealed similar results (140 [1.1%] vs. 67 [0.5%]; OR, 2.10; 95% CI, 1.57–2.82; p < 0.001; Table 3). Hospital-free days and ICU-free days to day 30 were also shorter in patient in the angiography group than in those in the non-angiography group (2 [0–17] vs. 10 [0–22] days; difference in median, 0 [95% CI, 0–0] days; and 16 [0–25] vs. 20 [7–27] days; difference in median, 2 [95% CI, 1–2] days, respectively, Table 3).

Table 3 Angiography and clinical outcomes

Inverse probability weighting analysis confirmed that the emergency angiography was associated with the higher incident of subsequent AKI (OR, 1.48; 95% CI, 1.32–1.67; Additional file 1: Table S1), and logistic regression with propensity score as a covariate identified the similar results (OR, 2.38; 95% CI, 1.86–3.04; Additional file 1: Table S1).

Subgroup analysis

In the subgroup analyses (Table 4), the relationship between higher incidence of subsequent AKI and emergency angiography was observed in several subgroups: severe and mild/moderate injury, resuscitation with and without vasopressors, and early and late period of injury during the study period.

Table 4 In-hospital mortality in subgroup analyses

Conversely, patients who had CKD before injury had comparable incidence of AKI regardless of emergency angiography, whereas those without history of CKD developed AKI more frequently when they underwent emergency angiography (OR, 2.13; 95% CI, 1.58–2.86).

Furthermore, emergency angiography was associated with increased subsequent AKI among relatively younger patients who were aged < 65 years (OR, 2.64; 95% CI, 1.82–3.84), whereas the incidence of AKI was comparable between the angiography and non-angiography groups among those who were aged ≥ 65 years.

Discussion

In this retrospective study, emergency angiography was associated with higher incidence of subsequent AKI. This relationship was validated even after several background risks for kidney injury and injury severity were adjusted. Thus, a future prospective study using predefined criteria for AKI is expected to be conducted for the validation of the current study.

Several pathophysiological mechanisms could be considered for the results in this study. First, the accumulated dose of contrast media is likely similar to the dosage used for coronary angiography (about 200 to 300 ml), and this amount of contrast is validated as a major risk factor for PC-AKI [22, 23]. During emergency angiography, radiologists usually use low-dose contrast (100 to 150 ml) [13] in an effort to avoid PC-AKI [22, 24]; however, most trauma patients would have undergone CT scan prior to angiography [25, 26] and received an additional 50 to 120 ml of contrast [13, 27]. Second, trauma victims who needed emergency angiography are bleeding, subsequently reducing intravascular volume. As decreased blood flow in the renal arteries precipitates kidney injury [10], the addition of contrast presents an increased risk of nephrotoxicity. Third, systemic inflammation following severe injury affects the tolerance for kidney insult by contrast media. Given that increased acute inflammation is associated with increased risk of PC-AKI [28], background risks of AKI would be high among patients in this study.

In the subgroup analyses, patients with a history of CKD did not have higher incidence of AKI after exposure to the contrast media, which is different from previous studies [29, 30]. One of the possibilities would be potential differences in procedures of angiography between patients with and without CKD. In Japan, standard practice by radiologists in the setting of CKD is to utilize alternative contrast agents [31, 32], and therefore in these cases radiologists would have used less-nephrotoxic agent such as carbon dioxide, instead of contrast media, when baseline kidney function was severely compromised. It should be also emphasized that the 95% CI of OR for developing AKI was wide (0.16–6.15) and including more patients with CKD would possibly reach a different result. Moreover, the length of hospital stay (LOS) was comparable between the angiography and non-angiography groups, although past studies suggested that PC-AKI was associated with prolonged hospital stay [33]. Considering that the incidence of subsequent AKI was rare in this study, the small number of patients with AKI might not have significantly affected LOS in all the patients. Notably, the length of ventilator usage was longer by 1–2 days in patients treated with the angiography.

Some potential preventions for PC-AKI can be considered if emergency angiography is validated as an independent risk for PC-AKI by a future study. Given that preprocedural hydration with saline or bicarbonate has been shown to prevent PC-AKI [34,35,36], restoration of intravascular volume should be achieved before emergency angiography. As anti-inflammatory medications, such as statins, have shown promising results for the prevention of PC-AKI in clinical studies on coronary angiography [37], this potential treatment should be investigated as an adjunct in trauma patients who require an angiography. Urine alkalization is scheduled to be investigated in an upcoming randomized controlled trial and may become an option for PC-AKI prevention in the near future [38]. To define clinical benefits of such managements, the results in the current study should be further validated in prospective studies using uniform criteria for the diagnosis of AKI.

The results in this study must be interpreted within the context of the study design. We investigated data using the JTDB, which does not record details of emergency angiography, including the indication for the procedure. Thus, our results could have been different if the decision for emergency angiography had been dependent on unrecorded strong prognostic factors for AKI. Another limitation is that serum creatinine, urine output, and hemodialysis requirement were not available in the database. Although AKI was diagnosed and recorded by treating physicians according to published clinical criteria, the specific criteria used for AKI definition and/or the degree of AKI severity could not be evaluated in this study: As this is a significant limitation, a future prospective study must be conducted to validate the current results. Moreover, we defined the primary outcome as AKI that was subsequently developed after emergency angiography, regardless of the timing of the diagnosis. As CIN, CI-AKI, and PC-AKI are usually defined as newly developed or worsened kidney dysfunction within 2–3 days after the exposure to contrast media [9], our results would be different if such standard definitions are used. However, as no changes in serum creatinine and/or urine output within a few days would not deny the possibility of gradually deteriorating kidney dysfunction [39], examining the incidence of AKI for longer period would be more clinically relevant. Finally, we investigated only emergency angiographies that were urgently performed during the initial resuscitation. Therefore, the results in this study should not be applied to scheduled angiography, such as one performed for a pseudoaneurysm found later during the hospital course.

Conclusions

Emergency angiography was associated with increased incidence of subsequent AKI among trauma patients. This result should be validated in a future study using predefined criteria for the diagnosis of AKI. Prevention measures for PC-AKI, such as preprocedural hydration, should be considered in the setting of emergency angiography.

Availability of data and materials

The data of this study are available from the Japanese Association for Trauma Surgery and the Japanese Association for Acute Medicine; however, restrictions apply to the availability of these data, which were used under the license for the current study and so are not publicly available. However, data are available from the authors upon reasonable request and with permission of the Japanese Association for Trauma Surgery and the Japanese Association for Acute Medicine.

Abbreviations

AKI:

Acute kidney injury

ISS:

Injury Severity Scale

CIN:

Contrast-induced nephropathy

CI-AKI:

Contrast-induced AKI

PC-AKI:

Post-contrast AKI

JTDB:

Japan Trauma Data Bank

AIS:

Abbreviated Injury Scale

ISS:

Injury Severity Score

RT:

Resuscitative thoracotomy

REBOA:

Resuscitative endovascular balloon occlusion of the aorta

ICU:

Intensive care unit

CKD:

Chronic kidney disease

CI:

Confidence interval

GCS:

Glasgow Coma Scale

sBP:

Systolic blood pressures

OR:

Odds ratio

References

  1. 1.

    Matsushima K, Hogen R, Piccinini A, Biswas S, Khor D, Delapena S, et al. Adjunctive use of hepatic angioembolization following hemorrhage control laparotomy. J Trauma Acute Care Surg. 2020;88(5):636–43.

    Article  Google Scholar 

  2. 2.

    Zarzaur BL, Kozar R, Myers JG, Claridge JA, Scalea TM, Neideen TA, et al. The splenic injury outcomes trial: an American Association for the Surgery of Trauma multi-institutional study. J Trauma Acute Care Surg. 2015;79(3):335–42.

    Article  Google Scholar 

  3. 3.

    Sabe AA, Claridge JA, Rosenblum DI, Lie K, Malangoni MA. The effects of splenic artery embolization on nonoperative management of blunt splenic injury: a 16-year experience. J Trauma Acute Care Surg. 2009;67(3):565–72.

    Article  Google Scholar 

  4. 4.

    Shapiro M, McDonald AA, Knight D, Johannigman JA, Cuschieri J. The role of repeat angiography in the management of pelvic fractures. J Trauma Acute Care Surg. 2005;58(2):227–31.

    Article  Google Scholar 

  5. 5.

    Miller PR, Chang MC, Hoth JJ, Mowery NT, Hildreth AN, Martin RS, et al. Prospective trial of angiography and embolization for all grade III to V blunt splenic injuries: nonoperative management success rate is significantly improved. J Am Coll Surg. 2014;218(4):644–8.

    Article  Google Scholar 

  6. 6.

    Virdis F, Reccia I, Di Saverio S, Tugnoli G, Kwan SH, Kumar J, et al. Clinical outcomes of primary arterial embolization in severe hepatic trauma: a systematic review. Diagn Interv Imaging. 2019;100(2):65–75.

    CAS  Article  Google Scholar 

  7. 7.

    Dabbs DN, Stein DM, Scalea TM. Major hepatic necrosis: a common complication after angioembolization for treatment of high-grade liver injuries. J Trauma Acute Care Surg. 2009;66(3):621–9.

    Article  Google Scholar 

  8. 8.

    van der Vlies CH, Saltzherr TP, Reekers JA, Ponsen KJ, van Delden OM, Goslings JC. Failure rate and complications of angiography and embolization for abdominal and pelvic trauma. J Trauma Acute Care Surg. 2012;73(5):1208–12.

    Article  Google Scholar 

  9. 9.

    Ostermann M, Joannidis M. Acute kidney injury 2016: diagnosis and diagnostic workup. Critical Care. 2016;20(1).

  10. 10.

    van der Molen AJ, Reimer P, Dekkers IA, Bongartz G, Bellin MF, Bertolotto M, et al. Post-contrast acute kidney injury. Part 2: risk stratification, role of hydration and other prophylactic measures, patients taking metformin and chronic dialysis patients: Recommendations for updated ESUR Contrast Medium Safety Committee guidelines. Eur Radiol. 2018;28(7):2856–69.

    Article  Google Scholar 

  11. 11.

    Tsai TT, Patel UD, Chang TI, Kennedy KF, Masoudi FA, Matheny ME, et al. Contemporary incidence, predictors, and outcomes of acute kidney injury in patients undergoing percutaneous coronary interventions: insights from the NCDR Cath-PCI registry. JACC Cardiovasc Interv. 2014;7(1):1–9.

    Article  Google Scholar 

  12. 12.

    Aycock RD, Westafer LM, Boxen JL, Majlesi N, Schoenfeld EM, Bannuru RR. Acute kidney injury after computed tomography: a meta-analysis. Ann Emerg Med. 2018;71(1):44-53.e4.

    Article  Google Scholar 

  13. 13.

    Hsieh TM, Tsai TH, Liu YW, Hsieh CH. Risk factors for contrast-induced nephropathy and their association with mortality in patients with blunt splenic injuries. Int J Surg. 2016;35:69–75.

    Article  Google Scholar 

  14. 14.

    Haines RW, Fowler AJ, Kirwan CJ, Prowle JR. The incidence and associations of acute kidney injury in trauma patients admitted to critical care: a systematic review and meta-analysis. J Trauma Acute Care Surg. 2019;86(1):141–7.

    Article  Google Scholar 

  15. 15.

    Hatton GE, Wang YW, Isbell KD, Finkel KW, Kao LS, Wade CE. Urinary cell cycle arrest proteins urinary tissue inhibitor of metalloprotease 2 and insulin-like growth factor binding protein 7 predict acute kidney injury after severe trauma: a prospective observational study. J Trauma Acute Care Surg. 2020;89(4):761–7.

    CAS  Article  Google Scholar 

  16. 16.

    Yamamoto R, Cestero RF, Muir MT, Jenkins DH, Eastridge BJ, Funabiki T, et al. Delays in surgical intervention and temporary hemostasis using resuscitative endovascular balloon occlusion of the aorta (REBOA): influence of time to operating room on mortality. Am J Surg. 2020;220(6):1485–91.

    Article  Google Scholar 

  17. 17.

    Austin PC. An introduction to propensity score methods for reducing the effects of confounding in observational studies. Multivariate Behav Res. 2011;46(3):399–424.

    Article  Google Scholar 

  18. 18.

    Brookhart MA, Schneeweiss S, Rothman KJ, Glynn RJ, Avorn J, Stürmer T. Variable selection for propensity score models. Am J Epidemiol. 2006;163(12):1149–56.

    Article  Google Scholar 

  19. 19.

    Raux M, Sartorius D, Le Manach Y, David JS, Riou B, Vivien B. What do prehospital trauma scores predict besides mortality? J Trauma. 2011;71(3):754–9.

    PubMed  Google Scholar 

  20. 20.

    Lunt M. Selecting an appropriate caliper can be essential for achieving good balance with propensity score matching. Am J Epidemiol. 2014;179(2):226–35.

    Article  Google Scholar 

  21. 21.

    Leisman DE. Ten pearls and pitfalls of propensity scores in critical care research: a guide for clinicians and researchers. Crit Care Med. 2019;47(2):176–85.

    Article  Google Scholar 

  22. 22.

    Gurm HS, Dixon SR, Smith DE, Share D, Lalonde T, Greenbaum A, et al. Renal function-based contrast dosing to define safe limits of radiographic contrast media in patients undergoing percutaneous coronary interventions. J Am Coll Cardiol. 2011;58(9):907–14.

    Article  Google Scholar 

  23. 23.

    Zhao N, Chen Z, Zhou Y, Xu Q, Xu Z, Tong W, et al. Effects of a high dose of the contrast medium iodixanol on renal function in patients following percutaneous coronary intervention. Angiology. 2021;72(2):145–52.

    CAS  Article  Google Scholar 

  24. 24.

    Werner S, Bez C, Hinterleitner C, Horger M. Incidence of contrast-induced acute kidney injury (CI-AKI) in high-risk oncology patients undergoing contrast-enhanced CT with a reduced dose of the iso-osmolar iodinated contrast medium iodixanol. PLoS ONE. 2020;15(5):e0233433.

    CAS  Article  Google Scholar 

  25. 25.

    Matsumoto S, Jung K, Smith A, Yamazaki M, Kitano M, Coimbra R. Comparison of trauma outcomes between Japan and the USA using national trauma registries. Trauma Surg Acute Care Open. 2018;3(1):e000247.

    Article  Google Scholar 

  26. 26.

    Tsurukiri J, Ohta S, Mishima S, Homma H, Okumura E, Akamine I, et al. Availability of on-site acute vascular interventional radiology techniques performed by trained acute care specialists: a single-emergency center experience. J Trauma Acute Care Surg. 2017;82(1):126–32.

    Article  Google Scholar 

  27. 27.

    Davenport MS, Khalatbari S, Cohan RH, Dillman JR, Myles JD, Ellis JH. Contrast Material–induced Nephrotoxicity and Intravenous Low-Osmolality Iodinated Contrast Material: Risk Stratification by Using Estimated Glomerular Filtration Rate. Radiology. 2013;268(3):719–28.

    Article  Google Scholar 

  28. 28.

    Toso A, Leoncini M, Maioli M, Tropeano F, Di Vincenzo E, Villani S, et al. Relationship between inflammation and benefits of early high-dose rosuvastatin on contrast-induced nephropathy in patients with acute coronary syndrome: the pathophysiological link in the PRATO-ACS study (Protective Effect of Rosuvastatin and Antiplatelet Therapy on Contrast-Induced Nephropathy and Myocardial Damage in Patients With Acute Coronary Syndrome Undergoing Coronary Intervention). JACC Cardiovasc Interv. 2014;7(12):1421–9.

    Article  Google Scholar 

  29. 29.

    Jakobi T, Meyborg M, Freisinger E, Gebauer K, Stella J, Engelbertz C, et al. Feasibility and impact of carbon dioxide angiography on acute kidney injury following endovascular interventions in patients with peripheral artery disease and renal impairment. Journal of Nephrology. 2021.

  30. 30.

    Sebastià C, Páez-Carpio A, Guillen E, Paño B, Garcia-Cinca D, Poch E, et al. Oral hydration compared to intravenous hydration in the prevention of post-contrast acute kidney injury in patients with chronic kidney disease stage IIIb: a phase III non-inferiority study (NICIR study). Eur J Radiol. 2021;136:109509.

    Article  Google Scholar 

  31. 31.

    Criado E, Upchurch GR Jr, Young K, Rectenwald JE, Coleman DM, Eliason JL, et al. Endovascular aortic aneurysm repair with carbon dioxide-guided angiography in patients with renal insufficiency. J Vasc Surg. 2012;55(6):1570–5.

    Article  Google Scholar 

  32. 32.

    Hayakawa N, Kodera S, Ohki N, Kanda J. Efficacy and safety of endovascular therapy by diluted contrast digital subtraction angiography in patients with chronic kidney disease. Heart Vessels. 2019;34(11):1740–7.

    Article  Google Scholar 

  33. 33.

    James MT, Samuel SM, Manning MA, Tonelli M, Ghali WA, Faris P, et al. Contrast-induced acute kidney injury and risk of adverse clinical outcomes after coronary angiography: a systematic review and meta-analysis. Circ Cardiovasc Interv. 2013;6(1):37–43.

    Article  Google Scholar 

  34. 34.

    Jurado-Roman A, Hernandez-Hernandez F, Garcia-Tejada J, Granda-Nistal C, Molina J, Velazquez M, et al. Role of hydration in contrast-induced nephropathy in patients who underwent primary percutaneous coronary intervention. Am J Cardiol. 2015;115(9):1174–8.

    Article  Google Scholar 

  35. 35.

    Maioli M, Toso A, Leoncini M, Gallopin M, Tedeschi D, Micheletti C, et al. Sodium bicarbonate versus saline for the prevention of contrast-induced nephropathy in patients with renal dysfunction undergoing coronary angiography or intervention. J Am Coll Cardiol. 2008;52(8):599–604.

    CAS  Article  Google Scholar 

  36. 36.

    Maioli M, Toso A, Leoncini M, Micheletti C, Bellandi F. Effects of hydration in contrast-induced acute kidney injury after primary angioplasty: a randomized, controlled trial. Circ Cardiovasc Interv. 2011;4(5):456–62.

    Article  Google Scholar 

  37. 37.

    Kang WC, Kim M, Park SM, Kim B-K, Lee B-K, Kwon HM. Preventive effect of pretreatment with pitavastatin on contrast-induced nephropathy in patients with renal dysfunction undergoing coronary procedure: PRINCIPLE-II Randomized Clinical Trial. J Clin Med. 2020;9(11):3689.

    CAS  Article  Google Scholar 

  38. 38.

    Lombardi M, Molisana M, Genovesi E, De Innocentiis C, Limbruno U, Misuraca L, et al. PrevenTion of contrast-inducEd nephropAThy with urinE alkalinization: the TEATE study design. J Cardiovasc Med (Hagerstown). 2020;21(1):65–72.

    Article  Google Scholar 

  39. 39.

    Cheng W, Wu X, Liu Q, Wang H-S, Zhang N-Y, Xiao Y-Q, et al. Post-contrast acute kidney injury in a hospitalized population: short-, mid-, and long-term outcome and risk factors for adverse events. Eur Radiol. 2020;30(6):3516–27.

    CAS  Article  Google Scholar 

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Acknowledgements

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Funding

There is no financial support in this study.

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Authors

Contributions

RY, RC, JY, and JS contributed to the acquisition of data, conceived and designed the study, interpreted the data, drafted the manuscript, and revised the manuscript for important intellectual content. KM contributed to the acquisition of data, interpreted the data, and revised the manuscript for important intellectual content. All authors reviewed and discussed the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Ryo Yamamoto.

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Ethics approval and consent to participate

All collaborating hospitals obtained approval of their individual institutional review board (IRB) for conducting research with human participants (approval number 20090087 from the Keio University School of Medicine Keio, Institute of the corresponding author).

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The authors have no relevant conflicts of interest to disclose.

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Supplementary Information

Additional file 1: Table S1.

Development of AKI in sensitivity analyses.

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Yamamoto, R., Cestero, R.F., Yoshizawa, J. et al. Emergency angiography for trauma patients and potential association with acute kidney injury. World J Emerg Surg 16, 56 (2021). https://doi.org/10.1186/s13017-021-00400-0

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Keywords

  • Angiography
  • Embolization
  • Hemostasis
  • Acute kidney injury