- Open Access
Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO): 2017 update of the evidence-based guidelines from the world society of emergency surgery ASBO working group
- Richard P. G. ten Broek†1, 39Email author,
- Pepijn Krielen†1,
- Salomone Di Saverio2,
- Federico Coccolini3,
- Walter L. Biffl4,
- Luca Ansaloni3,
- George C. Velmahos5,
- Massimo Sartelli6,
- Gustavo P. Fraga7,
- Michael D. Kelly8,
- Frederick A. Moore9,
- Andrew B. Peitzman10,
- Ari Leppaniemi11,
- Ernest E. Moore12,
- Johannes Jeekel13,
- Yoram Kluger14,
- Michael Sugrue15,
- Zsolt J. Balogh16,
- Cino Bendinelli17,
- Ian Civil18,
- Raul Coimbra19,
- Mark De Moya20,
- Paula Ferrada21,
- Kenji Inaba22,
- Rao Ivatury21,
- Rifat Latifi23,
- Jeffry L. Kashuk24,
- Andrew W. Kirkpatrick25,
- Ron Maier26,
- Sandro Rizoli27,
- Boris Sakakushev28,
- Thomas Scalea29,
- Kjetil Søreide30, 31,
- Dieter Weber32,
- Imtiaz Wani33,
- Fikri M. Abu-Zidan34,
- Nicola De’Angelis35,
- Frank Piscioneri36,
- Joseph M. Galante37,
- Fausto Catena38 and
- Harry van Goor1
© The Author(s). 2018
- Received: 19 January 2018
- Accepted: 29 May 2018
- Published: 19 June 2018
Adhesive small bowel obstruction (ASBO) is a common surgical emergency, causing high morbidity and even some mortality. The adhesions causing such bowel obstructions are typically the footprints of previous abdominal surgical procedures. The present paper presents a revised version of the Bologna guidelines to evidence-based diagnosis and treatment of ASBO. The working group has added paragraphs on prevention of ASBO and special patient groups.
The guideline was written under the auspices of the World Society of Emergency Surgery by the ASBO working group. A systematic literature search was performed prior to the update of the guidelines to identify relevant new papers on epidemiology, diagnosis, and treatment of ASBO. Literature was critically appraised according to an evidence-based guideline development method. Final recommendations were approved by the workgroup, taking into account the level of evidence of the conclusion.
Adhesion formation might be reduced by minimally invasive surgical techniques and the use of adhesion barriers. Non-operative treatment is effective in most patients with ASBO. Contraindications for non-operative treatment include peritonitis, strangulation, and ischemia. When the adhesive etiology of obstruction is unsure, or when contraindications for non-operative management might be present, CT is the diagnostic technique of choice. The principles of non-operative treatment are nil per os, naso-gastric, or long-tube decompression, and intravenous supplementation with fluids and electrolytes. When operative treatment is required, a laparoscopic approach may be beneficial for selected cases of simple ASBO.
Younger patients have a higher lifetime risk for recurrent ASBO and might therefore benefit from application of adhesion barriers as both primary and secondary prevention.
This guideline presents recommendations that can be used by surgeons who treat patients with ASBO. Scientific evidence for some aspects of ASBO management is scarce, in particular aspects relating to special patient groups. Results of a randomized trial of laparoscopic versus open surgery for ASBO are awaited.
- Small bowel obstruction
Adhesive small bowel obstruction (ASBO) is one of the leading causes of surgical emergencies and in particular of surgical emergencies that require an emergent operations [1–4]. In the UK, small bowel obstruction was the indication for 51% of all emergency laparotomies . Scott et al. reported on seven emergency surgical procedures that account for 80% of all general surgery emergency admissions, morbidity, deaths, and healthcare expenditures in the USA . Adhesive small bowel obstruction was the most common diagnosis for both the top 2 (small bowel resection) and top 5 (adhesiolysis) procedures . Post-operative adhesions are the leading cause of small bowel obstructions, accounting for 60% of cases .
ASBO causes considerable harm, resulting in 8 days of hospitalization on average and an in-hospital mortality rate of 3% per episode [5–8]. Between 20 and 30% of patients with adhesive small bowel obstruction require operative treatment [1, 9–11]. Length of hospitalization and morbidity depend on the need for surgical intervention. Average hospitalization after surgical treatment of ASBO is 16 days, compared to 5 days following non-operative treatment . Associated costs in a Dutch study in 2016 were estimated at €16,305 for surgical and €2227 for non-operative treatment .
Although adhesive small bowel obstruction is a common condition, the prevention and treatment is often characterized by surgeons’ personal preferences rather than standardized evidence-based protocols. There is a large amount of conflicting and low-quality evidence in publications regarding treatment of adhesive small bowel obstruction.
Therefore, the World Society of Emergency Surgery (WSES) working group on ASBO has developed evidence-based guidelines to support clinical decision making in diagnosis and management of ASBO [11, 13]. In the present revision of these guidelines, all recommendations were updated according to the latest evidence available from the medical literature. Further, we have introduced two new sections: prevention of ASBO and special patient groups.
The guideline was written under the auspices of the WSES by the ASBO working group. Systematic searches of the MEDLINE and Embase databases were carried out in October 2016 using the keywords relevant to each section. Terms relevant to each section of the guideline were mapped to MEDLINE Medical Subjects Headings (MeSH) terms, as well as searched for as text items. Articles describing randomized controlled trials and systematic reviews were searched for using the methodological filters of the Scottish Intercollegiate Guidelines Network (http://www.sign.ac.uk/methodological-principles.html). The bibliographies of included articles were subsequently hand-searched for other relevant references, and experts in the field were asked if they found any relevant reports missing.
Classification of evidence per article
Level of evidence
Studies concerning diagnostic accuracy
Studies on complications or side effects, etiology, prognosis
Systematic review/meta-analysis of at least 2 independently performed level A2 studies
Double-blind controlled randomized comparative clinical trial of good study quality with an adequate number of study participants
Diagnostic test compared to reference test; criteria and outcomes defined in advance; assessment of test results by independent observers; independent interpretation of test results; adequate number of consecutive patients enrolled; all patients subjected to both tests
Prospective cohort with sufficient amount of study participants and follow-up, adequately controlled for confounders; selection in follow-up has been successfully excluded
Comparative studies, but without all the features mentioned for level A2 (including patient-control studies, cohort studies)
Diagnostic test compared to reference test, but without all the features mentioned in A2
Prospective cohort study, but without all the features mentioned for level A2 or retrospective cohort study or case-control study
Grading of the conclusions and recommendations according to the level of evidence and strength of recommendation
Conclusion based on
Systematic review (A1) or at least 2 independent studies with evidence level A2 (“there is evidence that…”)
One study with evidence level A2 or at least 2 independent studies with evidence level B (“it is likely that…”)
One study with evidence level B or level C (“there are indications that…”)
Expert opinion (“the working group recommends…”)
Weak recommendation (suggestion)
Conclusion and recommendations are graded according to the level of evidence from strong (“there is strong evidence for,” level A) to weak (“we cannot be confident,” level D). Recommendations were graded as strong recommendations (level I) or weak recommendation or suggestions (level II). Recommendations were considered strong recommendations if there is sufficient evidence (level A or B) demonstrating that the benefits of an intervention are of clinical importance and clearly outweigh the harm of the intervention. A concept guideline was sent to all involved for comment and approval after which internal consensus was reached between the members of the working group. Amendments were made based upon these comments, leading to the final version of this updated guideline.
The term “peritoneal adhesions” or simply “adhesions” is defined as fibrous tissue that connects surfaces or organs within the peritoneal cavity that are normally separated. Such adhesions are the results of a pathological healing response of the peritoneum upon injury, as opposed to the normal “ad integrum” repair . Typical adhesions form after peritoneal injury from abdominal surgery. Other conditions that may cause peritoneal injury resulting in adhesion formation include radiotherapy, endometriosis, inflammation, and local response to tumors. Adhesions from a non-operative etiology are often part of a more complex pathology that can cause chronic pain and complications as the result of adhesions and other mechanisms . Management of chronic abdominal complications by adhesiolysis is controversial [18, 19]. The scope of the present guideline is limited to diagnosis and management of acute bowel obstructions.
Adhesive small bowel obstruction
Small bowel obstruction is a surgical emergency in which the obstruction of the small intestine hinders passage of intestinal contents. Small bowel obstruction is characterized by abdominal pain, vomiting, distention, and constipation. Adhesions are the single most common cause for small bowel obstruction [1, 20]. Nonadhesive etiologies of bowel obstruction include incarcerated hernias, obstructive lesions (malignant and benign), and a number of infrequent causes for bowel obstruction such as bezoars, inflammatory bowel disease, and volvulus [21–25]. Definitive confirmation of the adhesive etiology of bowel obstruction is made during operative treatment. Methods to confirm the adhesive etiology of bowel obstruction non-invasively include a history of previous episodes of bowel obstruction by adhesions or exclusion of other causes of bowel obstruction by imaging (often CT scan).
Seromuscular injury: injury to the visceral peritoneum (serosa) and smooth muscle layer of the bowel. The lumen of the bowel or leakage of bowel contents is not visible.
Enterotomy: a full thickness injury to the bowel. The mucous layer or lumen of the bowel is visible, or there may be leakage of intestinal contents.
Delayed diagnosed perforation: bowel injuries made during surgery that initially go unrecognized. Typically, the abdomen is closed at the end of procedure with the bowel injury still in place, causing patients to deteriorate during the postoperative course.
The risk of SBO is highest following colorectal, oncologic gynecological, or pediatric surgery [1, 26–28]. One in ten patients develops at least one episode of SBO within 3 years after colectomy . Reoperations for ASBO occur in between 4.2 and 12.6% of patients after pediatric surgery patients, and 3.2% of colorectal patients [1, 29]. Recurrence of ASBO is also frequent; 12% of non-operatively treated patients are readmitted within 1 year, rising to 20% after 5 years. The risk of recurrence is slightly lower after operative treatment: 8% after 1 year and 16% after 5 years .
Classification of adhesions
Classification of adhesions according to Zühlke et al.
No adhesions or insignificant adhesions
Adhesions that are filmy and easy to separate by blunt dissection
Adhesions where blunt dissection is possible but some sharp dissection necessary, beginning vascularization
Lysis of adhesions possible by sharp dissection only, clear vascularization
Lysis of adhesions possible by sharp dissection only, organs strongly attached with severe adhesions, damage of organs hardly preventable
A different type of classification in the field of ASBO is risk stratification that predicts the need for surgery. Zielinski reported on three radiological and clinical signs that correlate with the need for surgical exploration: mesenteric edema, absence of the small-bowel feces sign, and obstipation. The score was validated in 100 cases of ASBO and predicted the risk with a concordance index of 0.77 . A more accurate model was reported by Baghdadi et al. This score comprises radiological findings, sepsis criteria, and comorbidity index. Although the score is somewhat complex to assess, it correlates with an area under the curve of 0.80 in a validation study of 351 cases .
The main principles of prevention of adhesion and related complications are minimizing surgical trauma and the use of adjuvants to reduce adhesion formation. Laparoscopy is often believed to reduce adhesion formation and the risk for ASBO. In a systematic review of cohort studies, the incidence of reoperation for ASBO was 1.4 (95% CI 1.0–1.8%) after laparoscopic and 3.8% (95% CI 3.1–4.4%) after open surgery. However, there were differences in both the type and indications for surgery . In a recent meta-analysis of SBO after colorectal operations, the incidence of ASBO after laparoscopic surgery was somewhat lower than after open colorectal procedures (OR 0.62, 95% CI 0.54 to 0.72). However, no significant difference was found in the three randomized trials included in this review (OR 0.50, 95% CI 0.20 to 1.2) . In summary, there is some evidence that the incidence of ASBO is lower after laparoscopy. However, the effect seems modest when correcting for type and indication of surgery. Thus, performing (colorectal) surgery by laparoscopy is not a complete solution to preventing adhesive SBO.
Many other aspects of surgical technique have been associated with adhesion formation, although there are little or no epidemiological data concerning their impact on the incidence of ASBO. Nevertheless, a number of important risk factors for aggravated adhesion formation are worth considering. One of the most important risk factors is the foreign body reaction, for example as seen with starch-powdered gloves, and meshes used for abdominal wall reconstruction [40, 41]. The choice of energy device might also impact adhesion formation. Peritoneal injury is lower in bipolar electrocautery and ultrasonic devices as compared to monopolar electrocautery [42, 43]. Animal data suggest that both systemic and intraperitoneal application of antibiotics, and metronidazole in particular, can reduce adhesion formation in septic conditions [44, 45].
Adhesion barriers are adjuvants for peritoneal administration that can effectively reduce adhesion formation. Adhesion barriers are produced in several forms: solid membranes, gels, and liquids. The concept behind barriers is that they do not actively interfere with inflammation and wound healing. Rather, they act as a spacer which separates injured surfaces of the peritoneum, allowing these surfaces to heal without forming fibrinous attachments which eventually lead to adhesions. In order to accomplish this task, such barriers should ideally be inert to the human immune system and be slowly degradable.
Overview of most common applied adhesion barriers and their impact on adhesion formation and incidence of ASBO
Solid barrier most suitable for open surgery although laparoscopic placement has been described
Studies in both general surgery and gynecological procedures
Reduces adhesion formation, as well as the risk for reoperations for adhesive small bowel obstruction (relative risk 0.49, 95% CI 0.28–0.88)
Oxidized regenerated cellulose
Solid barrier most suitable for open surgery
Only studied in gynecological procedures
Reduces incidence of adhesion formation relative risk 0.51, 95% CI 0.31–0.86
No studies available on subsequent risk of ASBO
This workgroup does not recommend the use of this barrier to prevent ASBO in general surgery
Liquid barrier, easy to apply in both open and laparoscopic surgery
Good safety record in both general surgery and gynecological surgery
Reduces recurrence of ASBO following surgery for ASBO in one trial (relative risk 0.20, 95% CI 0.04–0.88)
Gel barrier, easy to apply in both open and laparoscopic surgery
Reduces adhesion score in both general surgery and gynecological trials
Relative few and small studies, impact on long-term adhesion-related complications not described
Adhesion barriers might also be useful to prevent recurrence after surgical treatment of ASBO. One randomized trial with an adhesion barrier included patients undergoing surgery for ASBO . In this trial, patients were randomized to a liquid 4% icodextrin adhesion barrier or standard operative treatment without an adhesion barrier. The ASBO recurrence rate was 2.19% (2/91) in the icodextrin groups versus 11.11% (10/90) in the control group after a mean follow-up period of 41.4 months (p < 0.05) . In this trial, the barrier was applied in patients treated for ASBO by laparotomy. However, the icodextrin 4% adhesion barrier can also be administered in laparoscopic surgery. Other trials with icodextrin as an adhesion barrier indicated that it actually might not be the most potent barrier to prevent adhesion reformation, which is typically more challenging than prevention of de novo adhesions . Favoring the use of icodextrin are its low costs and good safety record . From the results of other trials, we suggest that a hyaluronate carboxymethylcellulose might be more efficacious, but this barrier is less practical in laparoscopic surgery [46–48, 52].
Approach to the patient with ASBO
Differentiating between adhesive small bowel obstruction and other causes of bowel obstruction
Assessing the need for urgent surgical exploration
Identifying and preventing complications from bowel obstruction
History taking and physical examination
History taking in a patient suspected for ASBO includes assessment of potential causes of bowel obstruction (previous operations, radiotherapy) and nutritional status. Signs of dehydration should also be assessed. Traditionally, ASBO is clinically diagnosed in a patient with intermittent colicky abdominal pain, distention, and nausea (with or without vomiting), with or without absence of stools. Although diagnosis of small bowel obstruction is fairly certain in a patient in whom all of these symptoms are present, there are some specific pitfalls that can result in delayed or misdiagnosis of bowel obstruction upon initial presentation. In patients with incomplete obstruction, watery diarrhea may be present. The presence of watery diarrhea can cause an episode of ASBO to be mistaken for gastro-enteritis. Stools might also be present in patients with a relatively high obstruction who are admitted early after onset of symptoms. Moreover, not all of these symptoms may be present, especially in the elderly in whom pain is often less prominent [55, 56].
During physical examination, signs of peritonitis that might reveal strangulation or ischemia should be evaluated. Differential diagnostic considerations that can be assessed during physical examination include the presence of any abdominal wall or groin hernias. The evaluation of ASBO by history taking and physical examination has a low sensitivity for detecting bowel strangulation and ischemia. Sensitivity of physical examination for detection of strangulation is only 48%, even in experienced hands .
The minimum of laboratory tests include blood count, lactate, electrolytes, CRP, and BUN/creatinine. Laboratory values that might indicate peritonitis are a CRP > 75 and white blood cell count > 10.000/mm3, although sensitivity and specificity of these tests are relatively low [6, 57, 58]. Electrolytes are often disturbed in patients with a bowel obstruction; in particular, low values of potassium are frequently found and need to be corrected. BUN/creatinine needs to be assessed as patients with ASBO are frequently dehydrated which could result in acute kidney injury.
The value of plain X-rays complementary to physical examination is limited. In high-grade obstruction, a triad of multiple air-fluid levels, distention of small bowel loops, and absence of gas in the colon are pathognomonic for small bowel obstruction, but overall sensitivity and specificity of plain x-rays are low (sensitivity approximately 70%) [59, 60]. A large volume pneumoperitoneum secondary to bowel perforation in ASBO can also be detected on plain X-rays, preferably by an erect chest X-ray. Plain X-rays, however, do not detect the more early signs of peritonitis or strangulation [59–61]. Furthermore, a plain abdominal X-ray does not provide anatomical information that helps differentiate between the various causes of bowel obstruction.
Water-soluble contrast studies
Several systematic reviews and meta-analyses have established the usefulness of water-soluble contrast agents in the diagnostic work-up of ASBO [62–64]. If the contrast has not reached the colon on an abdominal X-ray taken 24 h following administration of the contrast, this is highly indicative of failure of non-operative management. Multiple studies have shown that the use of water-soluble contrast agents accurately predicts the need for surgery and reduces hospital stay [62, 63]. Some authors also suggest that water-soluble contrast studies reduce the need for surgery, which is attributed to an active therapeutic role of the contrast [62, 63].
Current helical CT scans not only have good test characteristics for diagnosing small bowel obstruction but also have approximately 90% accuracy in predicting strangulation and the need for urgent surgery [37, 60, 65–68]. Diagnostic value of CT scan can be enhanced with the use of water-soluble contract. As with water-soluble contrast studies, progress of the contrast can be evaluated by X-ray at 24 h after CT scan.
Although adhesions are not directly visible even on CT scan, a CT scan can differentiate accurately between different causes of bowel obstruction by excluding other causes. The workgroup therefore considers CT scan to be the preferred imaging technique if there is any doubt about the diagnosis of ASBO, and to assess the need for urgent surgery.
A CT scan should help to differentiate between a complete obstruction of the bowel and help facilitate the decision for a trial of non-operative management versus a decision to proceed to surgery. It may also help to define the location of the obstruction (e.g., high in the jejunum or deep in the pelvis). Signs of a closed loop, bowel ischemia, and free fluid are signs that suggest the need for surgery without delay. In addition, radiological and clinical scores can be used to predict the need for surgery as described above [37, 38].
Ultrasound and MRI
Although the working group considered CT scan to be the preferred technique for diagnosis of ASBO, ultrasound and MRI might be useful in specific situations. Ultrasound is operator dependent but in experienced hands can provide more information than plain X-rays, and is also available in most low income settings. Apart from distension of bowel loops, ultrasound enables detection of free fluid (that might indicate the need for urgent surgery) and assessment of the degree of shock in dehydrated patients [61, 69]. Ultrasound can also be of value in situations in which exposure to radiation is undesirable, such as in pregnant patients. In these cases, ultrasound might be complemented with MRI for more anatomical information if the diagnosis of bowel obstruction is confirmed .
Overview of conclusions and recommendation
Adhesive small bowel obstruction is a leading cause of morbidity, deaths, and healthcare expenditures in emergency surgery.
A2 Scott 2016; NELA project team 2016
Adhesive small bowel obstruction causes high morbidity, with average hospital stay of 8 days and 3% in-hospital mortality per episode. Recurrence of adhesive small bowel obstruction is high. Risk for adhesive small bowel obstruction may be somewhat lower after laparoscopic compared to open colorectal surgery, but that results could not be confirmed in randomized trials.
A2 ten Broek 2013; Yamada 2016; B Krielen 2016; Foster 2006
Laparoscopic surgery reduces adhesion formation and might reduce subsequent incidence of ASBO.
B Lundorff 1992; ten Broek 2013; Yamada 2016
Hyaluronate carboxymethylcellulose reduces adhesion formation and the risk of subsequent reoperations of adhesive SBO. The use of this barrier seems cost-effective in open colorectal surgery.
A1 ten Broek 2014; A2 Fazio 2006; Park 2009; Kusunoki 205
In the absence of signs that require emergent surgical exploration (i.e., peritonitis, strangulation, or bowel ischemia), non-operative management is the treatment strategy of choice.
C Fevang 2002; Fevang 2004; Ten Broek 2013; Jeppesen 2016
A trial of non-operative management can be continued safely for 72 h.
B Keenan 2014; Sakakibara 2007
Initial evaluation should be complemented with assessment of nutritional status and laboratory tests evaluating at least blood count, lactate, electrolytes, and BUN/Creat
Plain X-rays have only limited value in the work-up of patients with small bowel obstruction and are not recommended.
B Maglinte 1996
Optimal diagnostic work-up should include CT scan in the assessment and water soluble oral contrast. In the absence of the need to perform immediate surgery, a follow-up abdominal X-ray should be made after 24 h. If the contrast has reach the colon, this is indicative for resolution of the bowel obstruction.
A2 Ceresoli 2016; Branco 2010; Abbas 2005; B Goussous 2013; Zielinski 2011; Zielinski 2010; Daneshmat 1999; Makita 1999; Zalcman 2000
Long trilumen naso-intestinal tubes are more efficacious than naso-gastric tubes in non-operative management, but require endoscopic placement.
Laparoscopic adhesiolyis might reduce morbidity in selected cases of ASBO that require surgery. Results of a randomized trial are awaited.
B Sajid 2016; Farinella 2009; Sallinen 2014
Adhesion barriers reduce the risk of recurrence for ASBO following operative treatment.
A2 Catena 2012
Younger patients, and pediatric patients in particular, have higher lifetime risk of developing adhesion-related complications and might therefore benefit most from adhesion prevention.
A1 ten Broek 2013; A2 Strik 2016; B Fredriksson 2016
More research is needed to the impact of comorbidities in elderly patients on optimal management of adhesive small bowel obstruction. Patients with diabetes might require more early operative intervention.
B Karamanos 2016
Initial decision making
Non-operative management should always be tried in patients with adhesive small bowel obstruction, unless there are signs of peritonitis, strangulation, or bowel ischemia . Although the risk of recurrence is slightly lower after operative treatment, this is not a reason to opt for a primary surgical approach. Morbidity from emergency surgical exploration is high; there is a considerable risk for bowel injury, and surgical treatment may significantly reduce post-operative quality of life [1, 72–74].
The cornerstone of non-operative management is nil per os and decompression using a naso-gastric tube or long intestinal tube. Non-operative management is effective in approximately 70–90% of patients with ASBO [1, 75, 76]. There has been some debate in the literature over the use of long intestinal tubes or naso-gastric tubes. In an older trial, no significant difference in failure rates was found between naso-gastric tubes and long intestinal tubes . In a more recent trial, 186 patients were randomized between a newly designed trilumen long tube and a naso-gastric tube. Long tubes seemed more effective in this trial with a failure rate of 10.4% in this group compared with 53.3% in the naso-gastric tube group . Results from this trial should be interpreted with care, because the failure rate of naso-gastric tube compression is much higher than would be expected from other literature. Moreover, a drawback of trilumen tubes is the need for endoscopic placement. Non-operative management should further include fluid resuscitation, correction of electrolyte disturbances, nutritional support, and prevention of aspiration.
Duration of the period in which non-operative management can be tried is subject to debate. Several retrospective series and databases have shown that delays in surgery increase morbidity and mortality [30, 71, 79, 80]. Evidence for the optimal duration of non-operative treatment is absent, but most authors and the panel consider a 72-h period as safe and appropriate [11, 58, 76, 79, 80]. Continuing non-operative treatment for more than 72 h in cases with persistent high output from a decompression tube, but no other signs of clinical deterioration, however, remains subject to debate. Common medical complications in patients with small bowel obstruction are dehydration with kidney injury, electrolyte disturbances, malnutrition, and aspiration.
Non-operative management: summary
The panel recommends a trial of non-operative management in all patients with ASBO, unless there are signs of peritonitis, strangulation, or bowel ischemia. Evidence for the optimal duration of non-operative is absent, but most authors and the panel consider a 72-h period as safe and appropriate. Further recommendations are found in Table 5.
Historically, abdominal exploration through laparotomy has been the standard treatment for adhesive small bowel obstruction. In recent years, however, laparoscopic surgery for ASBO has been introduced. The potential benefits of laparoscopy include less extensive adhesion (re)formation, earlier return of bowel movements, reduced post-operative pain, and shorter length of stay [81–83]. In a recent systematic review and meta-analysis of 14 non-randomized studies, laparoscopic adhesiolysis reduced risk of morbidity, in-hospital mortality, and surgical infections . However, there also seems strong selection bias in these series allocating mainly the less severe cases to laparoscopy. In a questionnaire among surgeons, 60% of the respondents reported to have performed laparoscopic adhesiolysis for ASBO in their practice, but half of them in less than 15% of cases .
Although laparoscopy might provide some benefits to some patients for ASBO, surgeons should carefully select candidates for laparoscopic treatment. Laparoscopy in an abdomen with very distended loops of bowel and multiple complex adhesions could increase the risk of severe complications such as enterotomies and delayed diagnosis of perforations [85, 86]. Indeed, some authors have reported bowel injury in 6.3 to 26.9% of patients treated with laparoscopic adhesiolysis for ASBO [87–89]. In a recent population-based study, bowel resections were significantly more frequent in laparoscopic surgery. Incidence of bowel resection was 53.5 versus 43.4% in laparoscopic versus open procedures . Farinella et al. reported that predictors for a successful laparoscopic treatment of ASBO are the following: ≤ 2 laparotomies in history, appendectomy as the operation in history, no previous median laparotomy incision, and a single adhesive band . Laparoscopic adhesiolysis also seems more difficult in patients who have previously been treated by radiotherapy .
More compelling evidence on the role of laparoscopy in surgery for ASBO is from an ongoing randomized trial and is still awaited . In this trial, strict inclusion and exclusion criteria have been used to select candidates in whom simple single band adhesions are expected.
Operative management: summary
Laparoscopic surgery has been introduced in recent years and might decrease morbidity in subgroups of patients undergoing surgery for ASBO. The risk of bowel injuries seems higher in laparoscopic surgery for ASBO. Therefore, careful selection of patients for laparoscopic surgery is required. Further recommendations are found in Table 5.
Special patient groups
The risk of adhesion-related complications is life-long. Although most small bowel obstructions will occur within the first 2 years after surgery, new cases continue to develop many years after the primary operation [1, 30, 72, 94, 95]. Also, the risk of requiring a future reoperation for unrelated causes is higher in younger patients . Pediatric patients, who are at the extreme of young age, have a high risk for adhesion-related complications . In a recent cohort of patients who underwent surgery at a pediatric age, the incidence of adhesive small bowel obstruction was 12.6% after a median follow-up of 14.7 years .
Young patients therefore might have the highest lifetime benefit from adhesion prevention . No trials with adhesion barriers have been performed in pediatric surgery, but a recent cohort study in pediatric patients showed a significant reduction in ASBO with the use of a hyaluronate carboxymethylcellulose adhesion barrier . After a follow-up of 24 months, 2.0% of pediatric patients operated with adhesion barrier versus 4.5% of patients operated on without adhesion barrier developed ASBO.
In elderly patients, quality of life considerations are extremely important in decision making. Patients with a high frailty index have a prolonged recovery after a surgical procedure and may not be able to return to their previous functional state and quality of life [98, 99].
The principles of treatment for adhesive small bowel obstruction might interfere with comorbidities and medication in the elderly patients. There is a marked paucity of research on the consequences of stopping or withholding oral medications when a patient is put on nil per os for non-operative treatment of small bowel obstruction. A recent cohort showed that patients with diabetes might require earlier intervention although the level of evidence is rather low. Patients with diabetes were shown to suffer from a 7.5% incidence of acute kidney injury and 4.8% incidence of myocardial infarction if the operation was delayed more than 24 h . The incidence of these complications was significantly higher when compared to diabetic patients that were operated within 24 h and non-diabetic patients with delayed operation.
Small bowel obstruction in pregnancy is very rare but represents an important clinical challenge with significant risk of fetal loss. In a recent review, 46 cases of bowel obstruction during pregnancy were found in literature from case series and case reports . Approximately half of cases were attributed to adhesions, most commonly from previous abdominal operations. Imaging studies performed to diagnose SBO in the case reports included ultrasound in ten cases (83%), abdominal X-ray in four patients (33%), MRI in four patients (33%), and a CT scan in three patients (25%). Strikingly, the failure rate of non-operative treatment in pregnant patients with ASBO was high. A total of 23 cases with ASBO were reported, in 17 of whom initial management was by a non-operative trial. Non-operative treatment failed in 16 cases (94%). Risk of fetal loss was 17% (n = 8) and risk of maternal death 2% (n = 1).
The conclusions and recommendations of this guideline have been summarized in Table 5. ASBO is a common surgical emergency, causing high morbidity and even some mortality. Surgeons should be aware that the adhesions causing such bowel obstructions are typically the footprints of previous abdominal surgical procedures or disease. Part of the adhesion formation can be prevented by application of minimal invasive surgical techniques and the use of adhesion barriers. Most cases of ASBO can be treated non-operatively. If operative treatment is required, a laparoscopic approach might be beneficial for simple cases. However, there is a considerable risk for conversion to an open laparotomy and care needs to be taken not to make bowel injury.
Availability of data and materials
Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.
RtB, PK, and SdS performed the search for relevant literature, graded the level of evidence of available literature, contributed to the conception of the draft, contributed with important scientific knowledge, and gave the final approval of the manuscript. FCo, WB, LA, GV, MS, GF, MK, FM, AB, AL, EM, JJ, YK, MS, AB, CB, IC, RC, MdM, PF, KI, RI, RL, JK, AK, RM, SR, BS, TS, KS, DW, IW, FAZ, NdA, RP, JM, and FCa contributed to the manuscript draft, critically revised the manuscript, contributed with important scientific knowledge, and gave the final approval of the manuscript. HvG supervised the literature study, contributed to the conception of the draft, critically revised the manuscript, contributed with important scientific knowledge, and gave the final approval of the manuscript. All authors read and approved the final manuscript.
Ethics approval and consent to participate
The authors declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Ten Broek RP, Issa Y, van Santbrink EJ, Bouvy ND, Kruitwagen RF, Jeekel J, et al. Burden of adhesions in abdominal and pelvic surgery: systematic review and met-analysis. BMJ. 2013;347:f5588.View ArticlePubMedPubMed CentralGoogle Scholar
- NELA Project Team. The second patient report of the National Emergency Laparotomy Audit (NELA). London: The Royal College of Anaesthetists; 2016.Google Scholar
- Scott JW, Olufajo OA, Brat GA, Rose JA, Zogg CK, Haider AH, et al. Use of national burden to define operative emergency general surgery. JAMA Surg. 2016;151(6):e160480.View ArticlePubMedGoogle Scholar
- Gale SC, Shafi S, Dombrovskiy VY, Arumugam D, Crystal JS. The public health burden of emergency general surgery in the United States: a 10-year analysis of the nationwide inpatient sample—2001 to 2010. J Trauma Acute Care Surg. 2014;77(2):202–8.View ArticlePubMedGoogle Scholar
- Kossi JA, Salminen PT, Laato MK. Surgical workload and cost of postoperative adhesion-related intestinal obstruction: importance of previous surgery. World J Surg. 2004;28(7):666–70.View ArticlePubMedGoogle Scholar
- Shih SC, Jeng KS, Lin SC, Kao CR, Chou SY, Wang HY, et al. Adhesive small bowel obstruction: how long can patients tolerate conservative treatment. World J Gastroenterol. 2003;9(3):603–5.View ArticlePubMedPubMed CentralGoogle Scholar
- Parikh JA, Ko CY, Maggard MA, Zingmond DS. What is the rate of small bowel obstruction after colectomy? Am Surg. 2008 October;74(10):1001–5.PubMedGoogle Scholar
- Shikata J, Ohtaki K, Amino K, Takeda Y. Nationwide investigations of intestinal obstruction in Japan. Jpn J Surg. 1990;20(6):660–4.View ArticlePubMedGoogle Scholar
- Pricolo VE, Curley F. CT scan findings do not predict outcome of nonoperative management in small bowel obstruction: retrospective analysis of 108 consecutive patients. Int J Surg. 2016;27:88–91.View ArticlePubMedGoogle Scholar
- Musiienko AM, Shakerian R, Gorelik A, Thomson BN, Skandarajah AR. Impact of introduction of an acute surgical unit on management and outcomes of small bowel obstruction. ANZ J Surg. 2016;86(10):831–5.View ArticlePubMedGoogle Scholar
- Di Saverio S, Coccolini F, Galati M, Smerieri N, Biffl WL, Ansaloni L, et al. Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO): 2013 update of the evidence-based guidelines from the world society of emergency surgery ASBO working group. World J Emerg Surg. 2013;8(1):42.View ArticlePubMedPubMed CentralGoogle Scholar
- Krielen P, van den Beukel BA, Stommel MW, Van GH, Strik C, Ten Broek RP. In-hospital costs of an admission for adhesive small bowel obstruction. World J Emerg Surg. 2016;11:49.View ArticlePubMedPubMed CentralGoogle Scholar
- Catena F, Di SS, Kelly MD, Biffl WL, Ansaloni L, Mandala V, et al. Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO): 2010 evidence-based guidelines of the World Society of Emergency Surgery. World J Emerg Surg. 2011;6:5.View ArticlePubMedPubMed CentralGoogle Scholar
- Guyatt GH, Oxman AD, Kunz R, Vist GE, Falck-Ytter Y, Schunemann HJ. What is "quality of evidence" and why is it important to clinicians? BMJ. 2008;336(7651):995–8.View ArticlePubMedPubMed CentralGoogle Scholar
- Guyatt GH, Oxman AD, Kunz R, Falck-Ytter Y, Vist GE, Liberati A, et al. Going from evidence to recommendations. BMJ. 2008;336(7652):1049–51.View ArticlePubMedPubMed CentralGoogle Scholar
- Duron JJ. Postoperative intraperitoneal adhesion pathophysiology. Color Dis. 2007;9(Suppl 2):14–24.View ArticleGoogle Scholar
- Kvaskoff M, Mu F, Terry KL, Harris HR, Poole EM, Farland L, et al. Endometriosis: a high-risk population for major chronic diseases? Hum Reprod Update. 2015;21(4):500–16.View ArticlePubMedPubMed CentralGoogle Scholar
- Swank DJ, Swank-Bordewijk SC, Hop WC, van Erp WF, Janssen IM, Bonjer HJ, et al. Laparoscopic adhesiolysis in patients with chronic abdominal pain: a blinded randomised controlled multi-centre trial. Lancet. 2003;361(9365):1247–51.View ArticlePubMedGoogle Scholar
- van den Beukel BA, de Ree R, van Leuven S, Bakkum EA, Strik C, Van Goor H, et al. Surgical treatment of adhesion-related chronic abdominal and pelvic pain after gynaecological and general surgery: a systematic review and meta-analysis. Hum Reprod Update. 2017;23(3):276–88.PubMedGoogle Scholar
- Catena F, Ansaloni L, Di Saverio S, Pinna AD. P.O.P.A. study: prevention of postoperative abdominal adhesions by icodextrin 4% solution after laparotomy for adhesive small bowel obstruction. A prospective randomized controlled trial. J Gastrointest Surg. 2012;16(2):382–8.Google Scholar
- Agresta F, Piazza A, Michelet I, Bedin N, Sartori CA. Small bowel obstruction. Laparoscopic approach. Surg Endosc. 2000;14(2):154–6.View ArticlePubMedGoogle Scholar
- Chowbey PK, Panse R, Sharma A, Khullar R, Soni V, Baijal M. Elective laparoscopy in diagnosis and treatment of recurrent small bowel obstruction. Surg Laparosc Endosc Percutan Tech. 2006;16(6):416–22.View ArticlePubMedGoogle Scholar
- Grassi R, Romano S, D'Amario F, Giorgio RA, Romano L, Pinto F, et al. The relevance of free fluid between intestinal loops detected by sonography in the clinical assessment of small bowel obstruction in adults. Eur J Radiol. 2004;50(1):5–14.View ArticlePubMedGoogle Scholar
- Nieuwenhuijzen M, Reijnen MM, Kuijpers JH, Van GH. Small bowel obstruction after total or subtotal colectomy: a 10-year retrospective review. Br J Surg. 1998;85(9):1242–5.View ArticlePubMedGoogle Scholar
- Zerey M, Sechrist CW, Kercher KW, Sing RF, Matthews BD, Heniford BT. The laparoscopic management of small-bowel obstruction. Am J Surg. 2007;194(6):882–7.View ArticlePubMedGoogle Scholar
- Montz FJ. Small bowel obstruction following radical hysterectomy: risk factors, incidence, and operative findings. Gynecol Oncol. 1994;53(1):114–20.View ArticlePubMedGoogle Scholar
- Ellis H, Moran BJ, Thompson JN, Parker MC, Wilson MS, Menzies D, et al. Adhesion-related hospital readmissions after abdominal and pelvic surgery: a retrospective cohort study. Lancet. 1999;353(9163):1476–80.View ArticlePubMedGoogle Scholar
- Lower AM, Hawthorn RJ, Clark D, Boyd JH, Finlayson AR, Knight AD, et al. Adhesion-related readmissions following gynaecological laparoscopy or laparotomy in Scotland: an epidemiological study of 24 046 patients. Hum Reprod. 2004;19(8):1877–85.View ArticlePubMedGoogle Scholar
- Fredriksson F, Christofferson RH, Lilja HE. Adhesive small bowel obstruction after laparotomy during infancy. Br J Surg. 2016;103(3):284–9.View ArticlePubMedGoogle Scholar
- Foster NM, McGory ML, Zingmond DS, Ko CY. Small bowel obstruction: a population-based appraisal. J Am Coll Surg. 2006;203(2):170–6.View ArticlePubMedGoogle Scholar
- Zühlke HV, Lorenz EMP, Straub EM, Savvas V. Pathophysiology and classification of adhesions. Langenbecks Archiv fur Chirurgie. 1990:1009–16.Google Scholar
- The American Fertility Society. The American Fertility Society classifications of adnexal adhesions, distal tubal occlusion, tubal occlusion secondary to tubal ligation, tubal pregnancies, mullerian anomalies and intrauterine adhesions. Fertil Steril. 1988;49(6):944–955.Google Scholar
- The American Fertility Society. Improvement of interobserver reproducibility of adhesion scoring systems. Adhesion scoring group. Fertil Steril. 1994;62(5):984–8.Google Scholar
- Johns DB, Keyport GM, Hoehler F, diZerega GS. Reduction of postsurgical adhesions with Intergel adhesion prevention solution: a multicenter study of safety and efficacy after conservative gynecologic surgery. Fertil Steril. 2001;76(3):595–604.View ArticlePubMedGoogle Scholar
- Coccolini F, Ansaloni L, Manfredi R, Campanati L, Poiasina E, Bertoli P, et al. Peritoneal adhesion index (PAI): proposal of a score for the "ignored iceberg" of medicine and surgery. World J Emerg Surg. 2013;8(1):6.View ArticlePubMedPubMed CentralGoogle Scholar
- Fugazzola P, Coccolini F, Nita GE, Montori G, Corman M, Adeskunkanmi AR, et al. Validation of peritoneal adhesion index as a standardized classification to universalize peritoneal adhesions definition. J Peritoneum (and other serosal surfaces). 2017;2:61–9.View ArticleGoogle Scholar
- Zielinski MD, Eiken PW, Heller SF, Lohse CM, Huebner M, Sarr MG, et al. Prospective, observational validation of a multivariate small-bowel obstruction model to predict the need for operative intervention. J Am Coll Surg. 2011;212(6):1068–76.View ArticlePubMedGoogle Scholar
- Baghdadi YMK, Morris DS, Choudhry AJ, Thiels CA, Khasawneh MA, Polites SF, et al. Validation of the anatomic severity score developed by the American Association for the Surgery of Trauma in small bowel obstruction. J Surg Res. 2016;204(2):428–34.View ArticlePubMedGoogle Scholar
- Yamada T, Okabayashi K, Hasegawa H, Tsuruta M, Yoo JH, Seishima R, et al. Meta-analysis of the risk of small bowel obstruction following open or laparoscopic colorectal surgery. Br J Surg. 2016;103(5):493–503.View ArticlePubMedGoogle Scholar
- Luijendijk RW, de L, Wauters CC, Hop WC, Duron JJ, Pailler JL, et al. Foreign material in postoperative adhesions. Ann Surg. 1996;223(3):242–8.View ArticlePubMedPubMed CentralGoogle Scholar
- Schreinemacher MH, Emans PJ, Gijbels MJ, Greve JW, Beets GL, Bouvy ND. Degradation of mesh coatings and intraperitoneal adhesion formation in an experimental model. Br J Surg. 2009;96(3):305–13.View ArticlePubMedGoogle Scholar
- Ten Broek RP, Wilbers J, van Goor H. Electrocautery causes more ischemic peritoneal tissue damage than ultrasonic dissection. Surg Endosc. 2011;25(6):1827–34.View ArticlePubMedGoogle Scholar
- Ten Broek RP, Kok-Krant N, Bakkum EA, Bleichrodt RP, van Goor H. Different surgical techniques to reduce post-operative adhesion formation: a systematic review and meta-analysis. Hum Reprod Update. 2013;19(1):12–25.View ArticlePubMedGoogle Scholar
- Kayaoglu HA, Ozkan N, Yenidogan E, Koseoglu RD. Effect of antibiotic lavage in adhesion prevention in bacterial peritonitis. Ulus Travma Acil Cerrahi Derg. 2013;19(3):189–94.View ArticlePubMedGoogle Scholar
- Wang XC, Gui CQ, Zheng QS. Combined therapy of allantoin, metronidazole, dexamethasone on the prevention of intra-abdominal adhesion in dogs and its quantitative analysis. World J Gastroenterol. 2003;9(3):568–71.View ArticlePubMedPubMed CentralGoogle Scholar
- Fazio VW, Cohen Z, Fleshman JW, Van GH, Bauer JJ, Wolff BG, et al. Reduction in adhesive small-bowel obstruction by Seprafilm adhesion barrier after intestinal resection. Dis Colon Rectum. 2006;49(1):1–11.View ArticlePubMedGoogle Scholar
- Kusunoki M, Ikeuchi H, Yanagi H, Noda M, Tonouchi H, Mohri Y, et al. Bioresorbable hyaluronate-carboxymethylcellulose membrane (Seprafilm) in surgery for rectal carcinoma: a prospective randomized clinical trial. Surg Today. 2005;35(11):940–5.View ArticlePubMedGoogle Scholar
- Park CM, Lee WY, Cho YB, Yun HR, Lee WS, Yun SH, et al. Sodium hyaluronate-based bioresorbable membrane (Seprafilm) reduced early postoperative intestinal obstruction after lower abdominal surgery for colorectal cancer: the preliminary report. Int J Color Dis. 2009;24(3):305–10.View ArticleGoogle Scholar
- Ten Broek RP, Bakkum EA, Laarhoven CJ, van Goor H. Epidemiology and prevention of postsurgical adhesions revisited. Ann Surg. 2016;263(1):12–9.View ArticlePubMedGoogle Scholar
- Trew G, Pistofidis G, Pados G, Lower A, Mettler L, Wallwiener D, et al. Gynaecological endoscopic evaluation of 4% icodextrin solution: a European, multicentre, double-blind, randomized study of the efficacy and safety in the reduction of de novo adhesions after laparoscopic gynaecological surgery. Hum Reprod. 2011;26(8):2015–27.View ArticlePubMedGoogle Scholar
- Menzies D, Pascual MH, Walz MK, Duron JJ, Tonelli F, Crowe A, et al. Use of icodextrin 4% solution in the prevention of adhesion formation following general surgery: from the multicentre ARIEL registry. Ann R Coll Surg Engl. 2006;88(4):375–82.View ArticlePubMedPubMed CentralGoogle Scholar
- Ten Broek RP, Stommel MW, Strik C, van Laarhoven CJ, Keus F, van Goor H. Benefits and harms of adhesion barriers for abdominal surgery: a systematic review and meta-analysis. Lancet. 2014;383(9911):48–59.View ArticlePubMedGoogle Scholar
- Ellis H, Crowe A. Medico-legal consequences of post-operative intra-abdominal adhesions. Int J Surg. 2009;7(3):187–91.View ArticlePubMedGoogle Scholar
- Choudhry AJ, Haddad NN, Rivera M, Morris DS, Zietlow SP, Schiller HJ, et al. Medical malpractice in the management of small bowel obstruction: a 33-year review of case law. Surgery. 2016;160(4):1017–27.View ArticlePubMedGoogle Scholar
- Laurell H, Hansson LE, Gunnarsson U. Acute abdominal pain among elderly patients. Gerontology. 2006;52(6):339–44.View ArticlePubMedGoogle Scholar
- Krause WR, Webb TP. Geriatric small bowel obstruction: an analysis of treatment and outcomes compared with a younger cohort. Am J Surg. 2015;209(2):347–51.View ArticlePubMedGoogle Scholar
- Sarr MG, Bulkley GB, Zuidema GD. Preoperative recognition of intestinal strangulation obstruction. Prospective evaluation of diagnostic capability. Am J Surg. 1983;145(1):176–82.View ArticlePubMedGoogle Scholar
- Loftus T, Moore F, VanZant E, Bala T, Brakenridge S, Croft C, et al. A protocol for the management of adhesive small bowel obstruction. J Trauma Acute Care Surg. 2015;78(1):13–9.View ArticlePubMedPubMed CentralGoogle Scholar
- Maglinte DD, Reyes BL, Harmon BH, Kelvin FM, Turner WW Jr, Hage JE, et al. Reliability and role of plain film radiography and CT in the diagnosis of small-bowel obstruction. AJR Am J Roentgenol. 1996;167(6):1451–5.View ArticlePubMedGoogle Scholar
- Daneshmand S, Hedley CG, Stain SC. The utility and reliability of computed tomography scan in the diagnosis of small bowel obstruction. Am Surg. 1999;65(10):922–6.PubMedGoogle Scholar
- Hefny AF, Corr P, Abu-Zidan FM. The role of ultrasound in the management of intestinal obstruction. J Emerg Trauma Shock. 2012;5(1):84–6.View ArticlePubMedPubMed CentralGoogle Scholar
- Ceresoli M, Coccolini F, Catena F, Montori G, Di SS, Sartelli M, et al. Water-soluble contrast agent in adhesive small bowel obstruction: a systematic review and meta-analysis of diagnostic and therapeutic value. Am J Surg. 2016;211(6):1114–25.View ArticlePubMedGoogle Scholar
- Branco BC, Barmparas G, Schnuriger B, Inaba K, Chan LS, Demetriades D. Systematic review and meta-analysis of the diagnostic and therapeutic role of water-soluble contrast agent in adhesive small bowel obstruction. Br J Surg. 2010;97(4):470–8.View ArticlePubMedGoogle Scholar
- Abbas S, Bissett IP, Parry BR. Oral water soluble contrast for the management of adhesive small bowel obstruction. Cochrane Database Syst Rev. 2005;1:CD004651.Google Scholar
- Goussous N, Eiken PW, Bannon MP, Zielinski MD. Enhancement of a small bowel obstruction model using the gastrografin(R) challenge test. J Gastrointest Surg. 2013;17(1):110–6.View ArticlePubMedGoogle Scholar
- Zielinski MD, Eiken PW, Bannon MP, Heller SF, Lohse CM, Huebner M, et al. Small bowel obstruction-who needs an operation? A multivariate prediction model. World J Surg. 2010;34(5):910–9.View ArticlePubMedPubMed CentralGoogle Scholar
- Makita O, Ikushima I, Matsumoto N, Arikawa K, Yamashita Y, Takahashi M. CT differentiation between necrotic and nonnecrotic small bowel in closed loop and strangulating obstruction. Abdom Imaging. 1999;24(2):120–4.View ArticlePubMedGoogle Scholar
- Zalcman M, Sy M, Donckier V, Closset J, Gansbeke DV. Helical CT signs in the diagnosis of intestinal ischemia in small-bowel obstruction. AJR Am J Roentgenol. 2000;175(6):1601–7.View ArticlePubMedGoogle Scholar
- Abu-Zidan FM. Optimizing the value of measuring inferior vena cava diameter in shocked patients. World J Crit Care Med. 2016;5(1):7–11.View ArticlePubMedPubMed CentralGoogle Scholar
- Abu-Zidan FM, Abdel-Kader S, Abusharia MI, Mousa H. Role of magnetic resonance imaging in the management of intestinal obstruction during the first trimester of pregnancy. ANZ J Surg. 2016;Google Scholar
- Fevang BT, Jensen D, Svanes K, Viste A. Early operation or conservative management of patients with small bowel obstruction? Eur J Surg. 2002;168(8–9):475–81.View ArticlePubMedGoogle Scholar
- Fevang BT, Fevang J, Lie SA, Soreide O, Svanes K, Viste A. Long-term prognosis after operation for adhesive small bowel obstruction. Ann Surg. 2004;240(2):193–201.View ArticlePubMedPubMed CentralGoogle Scholar
- Ten Broek RP, Strik C, Issa Y, Bleichrodt RP, van Goor H. Adhesiolysis-related morbidity in abdominal surgery. Ann Surg. 2013;258(1):98–106.View ArticlePubMedGoogle Scholar
- Jeppesen M, Tolstrup MB, Gogenur I. Chronic pain, quality of life, and functional impairment after surgery due to small bowel obstruction. World J Surg. 2016;40(9):2091–7.Google Scholar
- Fazel MZ, Jamieson RW, Watson CJ. Long-term follow-up of the use of the Jones' intestinal tube in adhesive small bowel obstruction. Ann R Coll Surg Engl. 2009;91(1):50–4.View ArticlePubMedPubMed CentralGoogle Scholar
- Schraufnagel D, Rajaee S, Millham FH. How many sunsets? Timing of surgery in adhesive small bowel obstruction: a study of the nationwide inpatient sample. J Trauma Acute Care Surg. 2013;74(1):181–7.View ArticlePubMedGoogle Scholar
- Fleshner PR, Siegman MG, Slater GI, Brolin RE, Chandler JC, Aufses AH Jr. A prospective, randomized trial of short versus long tubes in adhesive small-bowel obstruction. Am J Surg. 1995;170(4):366–70.View ArticlePubMedGoogle Scholar
- Chen XL, Ji F, Lin Q, Chen YP, Lin JJ, Ye F, et al. A prospective randomized trial of transnasal ileus tube vs nasogastric tube for adhesive small bowel obstruction. World J Gastroenterol. 2012;18(16):1968–74.View ArticlePubMedPubMed CentralGoogle Scholar
- Keenan JE, Turley RS, McCoy CC, Migaly J, Shapiro ML, Scarborough JE. Trials of nonoperative management exceeding 3 days are associated with increased morbidity in patients undergoing surgery for uncomplicated adhesive small bowel obstruction. J Trauma Acute Care Surg. 2014;76(6):1367–72.View ArticlePubMedGoogle Scholar
- Sakakibara T, Harada A, Yaguchi T, Koike M, Fujiwara M, Kodera Y, et al. The indicator for surgery in adhesive small bowel obstruction patient managed with long tube. Hepatogastroenterology. 2007;54(75):787–90.PubMedGoogle Scholar
- Nordin A, Freedman J. Laparoscopic versus open surgical management of small bowel obstruction: an analysis of clinical outcomes. Surg Endosc. 2016;30(10):4454–63.View ArticlePubMedGoogle Scholar
- Szomstein S, Lo ME, Simpfendorfer C, Zundel N, Rosenthal RJ. Laparoscopic lysis of adhesions. World J Surg. 2006;30(4):535–40.View ArticlePubMedGoogle Scholar
- Hackenberg T, Mentula P, Leppaniemi A, Sallinen V. Laparoscopic versus open surgery for acute adhesive small-bowel obstruction: a propensity score-matched analysis. Scand J Surg. 2017;106(1):28–33.View ArticlePubMedGoogle Scholar
- Sajid MS, Khawaja AH, Sains P, Singh KK, Baig MK. A systematic review comparing laparoscopic vs open adhesiolysis in patients with adhesional small bowel obstruction. Am J Surg. 2016;212(1):138–50.View ArticlePubMedGoogle Scholar
- Strik C, Stommel MW, Ten Broek RP, Van GH. Adhesiolysis in patients undergoing a repeat median laparotomy. Dis Colon Rectum. 2015;58(8):792–8.View ArticlePubMedGoogle Scholar
- Ten Broek RP, Strik C, Van GH. Preoperative nomogram to predict risk of bowel injury during adhesiolysis. Br J Surg. 2014;101(6):720–7.View ArticlePubMedGoogle Scholar
- Grafen FC, Neuhaus V, Schob O, Turina M. Management of acute small bowel obstruction from intestinal adhesions: indications for laparoscopic surgery in a community teaching hospital. Langenbeck's Arch Surg. 2010;395(1):57–63.View ArticleGoogle Scholar
- Wullstein C, Gross E. Laparoscopic compared with conventional treatment of acute adhesive small bowel obstruction. Br J Surg. 2003;90(9):1147–51.View ArticlePubMedGoogle Scholar
- Johnson KN, Chapital AB, Harold KL, Merritt MV, Johnson DJ. Laparoscopic management of acute small bowel obstruction: evaluating the need for resection. J Trauma Acute Care Surg. 2012;72(1):25–30.View ArticlePubMedGoogle Scholar
- Behman R, Nathens AB, Byrne JP, Mason S, Look HN, Karanicolas PJ. Laparoscopic surgery for adhesive small bowel obstruction is associated with a higher risk of bowel injury: a population-based analysis of 8584 patients. Ann Surg. 2017;266(3):489–98.View ArticlePubMedGoogle Scholar
- Farinella E, Cirocchi R, La MF, Morelli U, Cattorini L, Delmonaco P, et al. Feasibility of laparoscopy for small bowel obstruction. World J Emerg Surg. 2009;4:3.View ArticlePubMedPubMed CentralGoogle Scholar
- Nakamura T, Ishii Y, Tsutsui A, Kaneda M, Sato T, Watanabe M. Safety and indications of laparoscopic surgery for postoperative small-bowel obstruction: a single-center study of 121 patients. Surg Laparosc Endosc Percutan Tech. 2017;27(4):301–5.View ArticlePubMedGoogle Scholar
- Sallinen V, Wikstrom H, Victorzon M, Salminen P, Koivukangas V, Haukijarvi E, et al. Laparoscopic versus open adhesiolysis for small bowel obstruction—a multicenter, prospective, randomized, controlled trial. BMC Surg. 2014;14:77.View ArticlePubMedPubMed CentralGoogle Scholar
- Duron JJ, Silva NJ, du Montcel ST, Berger A, Muscari F, Hennet H, et al. Adhesive postoperative small bowel obstruction: incidence and risk factors of recurrence after surgical treatment: a multicenter prospective study. Ann Surg. 2006;244(5):750–7.View ArticlePubMedPubMed CentralGoogle Scholar
- Parker MC, Ellis H, Moran BJ, Thompson JN, Wilson MS, Menzies D, et al. Postoperative adhesions: ten-year follow-up of 12,584 patients undergoing lower abdominal surgery. Dis Colon Rectum. 2001;44(6):822–9.View ArticlePubMedGoogle Scholar
- Strik C, Stommel MW, Schipper LJ, Van GH, Ten Broek RP. Risk factors for future repeat abdominal surgery. Langenbeck's Arch Surg. 2016;401(6):829–37.Google Scholar
- Inoue M, Uchida K, Otake K, Nagano Y, Ide S, Hashimoto K, et al. Efficacy of Seprafilm for preventing adhesive bowel obstruction and cost-benefit analysis in pediatric patients undergoing laparotomy. J Pediatr Surg. 2013;48(7):1528–34.View ArticlePubMedGoogle Scholar
- Bruce J, Krukowski ZH. Quality of life and chronic pain four years after gastrointestinal surgery. Dis Colon Rectum. 2006;49(9):1362–70.View ArticlePubMedGoogle Scholar
- Bakker FC, Persoon A, Bredie SJ, van Haren-Willems J, Leferink VJ, Noyez L, et al. The CareWell in hospital program to improve the quality of care for frail elderly inpatients: results of a before-after study with focus on surgical patients. Am J Surg. 2014;208(5):735–46.View ArticlePubMedGoogle Scholar
- Karamanos E, Dulchavsky S, Beale E, Inaba K, Demetriades D. Diabetes mellitus in patients presenting with adhesive small bowel obstruction: delaying surgical intervention results in worse outcomes. World J Surg. 2016;40(4):863–9.View ArticlePubMedGoogle Scholar
- Webster PJ, Bailey MA, Wilson J, Burke DA. Small bowel obstruction in pregnancy is a complex surgical problem with a high risk of fetal loss. Ann R Coll Surg Engl. 2015;97(5):339–44.View ArticlePubMedPubMed CentralGoogle Scholar