Non-iatrogenic esophageal injury: a retrospective analysis from the National Trauma Data Bank
© The Author(s). 2017
Received: 4 March 2017
Accepted: 18 April 2017
Published: 27 April 2017
Traumatic, non-iatrogenic esophageal injuries, despite their rarity, are associated with significant morbidity and mortality. The optimal management of these esophageal perforations remains largely debated. To date, only a few small case series are available with contrasting results. The purpose of this study was to examine a large contemporary experience with traumatic esophageal injury management and to analyze risk factors associated with mortality.
This National Trauma Data Bank (NTDB) database study included patients with non-iatrogenic esophageal injuries. Variables abstracted were demographics, comorbidities, mechanism of injury, Abbreviated Injury Scale (AIS), esophageal Organ Injury Scale (OIS), Injury Severity Score (ISS), level of injury, vital signs, and treatment. Multivariate analysis was used to identify independent predictors for mortality and overall complications.
A total of 944 patients with non-iatrogenic esophageal injury were included in the final analysis. The cervical segment of the esophagus was injured in 331 (35%) patients. The unadjusted 24-h mortality (8.2 vs. 14%, p = 0.008), 30-day mortality (4.2 vs. 9.3%, p = 0.005), and overall mortality (7.9 vs. 13.5%, p = 0.009) were significantly lower in the group of patients with a cervical injury. The overall complication rate was also lower in the cervical group (19.8 vs. 27.1%, p = 0.024). Multilogistic regression analysis identified age >50, thoracic injury, high-grade esophageal injury (OIS IV–V), hypotension on admission, and GCS <9 as independent risk factors associated with increased mortality. Treatment within the first 24 h was found to be protective (OR 0.284; 95% CI, 0.148–0.546; p < 0.001). Injury to the thoracic esophagus was also an independent risk factor for overall complications (OR 1.637; 95% CI, 1.06–2.53; p = 0.026).
Despite improvements in surgical technique and critical care support, the overall mortality for traumatic esophageal injury remains high. The presence of a thoracic esophageal injury and extensive esophageal damage are the major independent risk factors for mortality. Early surgical treatment, within the first 24 h of admission, is associated with improved survival.
KeywordsEsophageal trauma Non-iatrogenic esophageal injury Primary suture Outcomes
The management of iatrogenic and spontaneous perforations of the esophagus has well-established risk factors and treatment guidelines. In this setting, thoracic perforations are associated with poor outcomes because of the association with systemic sepsis and multi-organ failure [1–5]. In contrast, small and well-contained cervical perforations are associated with better outcomes . Prompt diagnosis and early treatment have been shown to improve outcomes [7–9].
Despite its rarity, traumatic esophageal injury is associated with a significant morbidity and mortality burden. To date, only a few small series are available in the literature addressing management and outcomes with contrasting results. As a result, our current understanding of the optimal treatment for these injuries is unclear.
The purpose of this study was to examine a large contemporary experience with traumatic esophageal injury management, to compare cervical and thoracic injury, and to analyze risk factors associated with mortality.
After Institutional Review Board approval, the National Trauma Data Bank (NTDB) was queried to identify all patients 16 years and older who sustained a traumatic esophageal injury (ICD-9 codes 862.22 and 862.32) over a 7-year period (2007–2014). Patients transferred from an outside hospital and those who died upon arrival were excluded from the study. Spontaneous (Boerhaave syndrome) and iatrogenic esophageal perforations that occurred during upper gastrointestinal endoscopy were also excluded from the final analysis.
Variables extracted from the NTDB included demographics, comorbidities, mechanism of injury, Abbreviated Injury Scale (AIS), Injury Severity Score (ISS), Organ Injury Scale (OIS), and vital signs in the emergency department. The location of the esophageal injury (cervical vs. thoracic), treatment modalities (primary repair vs. esophagectomy vs. esophagostomy), and timing of surgical treatment were abstracted. Outcomes of interest included in-hospital mortality, complications, ventilation days, ICU length of stay, and hospital length of stay.
The study population was further subdivided and analyzed by the level of esophageal injury: cervical or thoracic. Severe injury was defined as AIS 3 or higher in any body region. Early surgical treatment was defined as operative intervention performed in the first 24 h. Isolated esophageal injury was defined as an esophageal injury with no other associated injuries with an AIS ≥3.
Categorical variables were reported as percentages, while continuous variables were reported as medians with interquartile range (IQR). Continuous variables were also dichotomized using clinically relevant cut-off points. Univariate analysis was performed to identify differences between outcomes in groups of interest. The Mann-Whitney U test was used to compare continuous variables while Fisher’s exact or Pearson’s chi-squared test was used to compare proportions for categorical variables. Variables with p < 0.2 in univariate analysis were included into a forward stepwise logistic regression to identify independent predictors for mortality and the development of complications. Multicollinearity testing was performed to identify the correlation between variables. The accuracy of the test is calculated using the area under the curve with a 95% confidence interval. Variables with a p value <0.05 were considered significant. All statistical analysis was performed using SPSS for Windows version 23.0 (SPSS Inc. Chicago, IL).
Patients with an esophageal injury were more likely to be males (77.6%), with a median age of 35 years (IQR 24–52) and 27.4% were over 50 years of age. On admission, 9.4% of the cases were identified as being hypotensive (systolic blood pressure <90 mmHg), with a median heart rate of 97 (IQR 80–112), and a Glasgow Coma Scale (GCS) <9 was seen in 23.1% of cases.
Mechanism of injury
Demographics and clinical data according to the location of the esophageal injury
(n = 944)
(n = 613)
(n = 331)
Age (years), median (IQR)
Age >50 year
Chronic renal failure
SBP <90 mmHg
HR (bpm), median (IQR)
GCS score <9
ISS, median (IQR)
Associated injuries (AIS ≥3)
Isolated esophageal injury
Early treatment (≤24 h)
Patients presenting to the emergency department with an esophageal injury had a median ISS of 24 (IQR 16–33), with 80.6% having an ISS >15. Associated severe head, chest, and abdominal injuries were documented in 28.6, 91.1, and 17.1% of patients, respectively.
Injury to the thoracic esophagus occurred in 64.9% of patients, and the remaining 35.1% had a cervical esophageal injury. Patients with a cervical injury were also more likely to have an associated tracheal injury requiring surgical repair and needing tracheostomy (17.5 vs. 7.3%, p < 0.001 and 26 vs. 18.4%, p = 0.007, respectively). High-grade injury with full-thickness perforation occurred in 56.5% of patients (OIS III: n = 466, 49.4%; OIS IV/V: n = 68, 7.2%); low-grade esophageal injury occurred in 43.4% of patients (OIS I/II: n = 410). Overall, 218 patients (23.1%) had an isolated esophageal injury, and half of these had a low-grade injury (OIS I/II: n = 120, 55%).
Cervical esophageal injuries were more likely to occur following a penetrating mechanism (60.4 vs. 45.4%, p < 0.001) (Table 1). Compared to thoracic injuries, cervical injuries were less frequent after MVC (13.9 vs. 21.7%, p = 0.004) and less likely to have associated severe abdominal trauma (8.8 vs. 21.5%, p < 0.001). No difference in the median ISS, systolic blood pressure, GCS, and ISS >15 were noted in the two study groups (Table 1).
Different operative strategies according to the location of the esophageal injury
Thoracic (n = 613)
Cervical (n = 331)
Primary suture (n = 317)
Esophagectomy (n = 15)
Esophageal diversion/esophagostomy (n = 13)
Esophageal stent (n = 11)
Perivisceral drainage (n = 160)
Different operative strategies according to the esophageal Organ Injury Scale (OIS)
OIS I–II (n = 410)
OIS III (n = 466)
OIS IV–V (n = 68)
Primary suture (n = 317)
Esophagectomy (n = 15)
Esophageal diversion/esophagostomy (n = 13)
Esophageal stent (n = 11)
Perivisceral drainage (n = 160)
Outcome comparison between patients with a thoracic and cervical esophageal injury
(n = 944)
(n = 613)
(n = 331)
Mechanical ventilation (days)a, median (IQR)
ICU stay (days)a, median (IQR)
Hospital length of stay (days)a, median (IQR)
Acute kidney injury
Catheter related Blood infection
Overall infectious complication
Independent risk factors for mortality
95% CI for OR
Age >50 year
Severe head injury (AIS ≥3)
GCS score <9
Early treatment (≤24h)
The purpose of this study was to examine a large contemporary experience with traumatic esophageal injury, specifically with regard to the management, outcomes, and risk factors for mortality. Injury to the thoracic segment of the esophagus was found to be a major risk factor for mortality. Early treatment, within 24 h from admission, was independently associated with improved survival.
Traumatic esophageal injury is rare and associated with high morbidity and mortality. While previous studies have tried to describe outcomes, management, and risk factors for mortality, the limited sample size remained a major weakness.
In our study of more than 900 cases, the overall mortality rate was 12%. This is slightly lower compared to a 2001 retrospective multicenter study that analyzed patients with a penetrating esophageal injury (19%) . This finding likely reflects recent improvements in the treatment and critical care management of such patients. In accordance with a retrospective 2013 database study of 227 patients who sustained a penetrating esophageal injury, the majority of deaths (62.8%) occurred in the first 24 h of admission due to the severity of associated injuries . In our study, the mortality rate for cervical injuries was significantly lower than thoracic injuries. This result is in keeping with the current data showing that cervical injuries are associated with lower mortality . This may be due to the protected anatomical location of the cervical esophagus which limits lateral bacterial spillage avoiding downward mediastinal contamination . In contrast, injury to the thoracic segment of the esophagus is often associated with extensive, non-contained bacterial spillage with mediastinitis, pleural effusion, empyema, systemic sepsis, and multi-organ failure . Moreover, the negative intrathoracic pressure can exacerbate the bacterial spillage from the esophageal lumen into the thoracic cavity .
Primary repair was the most commonly adopted surgical approach. Debridement of necrotic tissue, complete exposure of the mucosal layer, and a tension-free repair is recommended whenever feasible. Massive destructive injuries may require a more aggressive approach using esophageal resection or diversion . In our study, the more invasive surgical procedures were performed for extensive esophageal injury. An early surgical procedure was performed in 79.7% of patients who underwent an operation. It has been previously advocated that early treatment is associated with improved outcomes because of limited bacterial spillage and less systemic inflammatory response. Brinster et al. in a 2004 literature review on 559 patients with esophageal perforation found that a treatment delay greater than 24 h can result in a doubled risk of mortality . Similarly, Asensio et al., in a retrospective multicenter study, found that a treatment delay of greater than 13 h was associated with a significant increase in the overall complication rate and worse outcomes . Discordant results were reported in a small retrospective single center study of 119 patients who sustained an iatrogenic or spontaneous perforation, with no difference in terms of mortality when comparing early and late treatment .
Non-operative management has been advocated for selected patients in the setting of iatrogenic and spontaneous esophageal perforation . Markar et al. in a large 12-year retrospective multicenter study of 2564 patients demonstrated a significant reduction in the overall number of surgical procedures with a concomitant increase in non-operative management . Minimally invasive endoscopic stenting or clipping for iatrogenic perforation has also been proposed for small discontinuities with viable, non-necrotic edges [18, 19]. These strategies may be useful in selected, hemodynamically stable trauma patients with a contained leak .
Because of the rarity of traumatic esophageal injury, limited data is available. For this reason, we chose to use the NTDB databank to collect a large study population, reducing the risk of a type II error. Exclusion of iatrogenic and spontaneous perforation makes our study population homogeneous, focusing only on traumatic esophageal injury. The major weaknesses of our study are related to its retrospective nature and to the fact that treatment delay of the esophageal injury may have been due to prioritizing treatment of other life-threatening injuries. We were not able to analyze the patient status in detail, and the elapsed time from the onset of symptoms to treatment was also unavailable in this administrative database. Moreover, the lack of specific details regarding the surgical procedure was a limitation.
Despite improvements in surgical technique and critical care support, the overall mortality for traumatic esophageal injury remains high. The presence of a thoracic injury and extensive esophageal damage are the major independent risk factors for mortality. Early surgical treatment is associated with improved survival.
Availability of data and materials
The datasets used and/or analyzed during the current study available from the corresponding author on reasonable request.
AA and EA did the literature search. AA, KI, and LB formed the study design. The data collection was done by AA. AA, GR, and DK analyzed the data. AA, KI, GR, and DD interpreted the data. AA, KI, and LB wrote the manuscript. KI, EB, LL, AS, LB, and DD critically reviewed the manuscript. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
Consent for publication
Ethics approval and consent to participate
Informed consent was obtained from all individual participants included in the study.
All procedures performed in the study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
The ethics committee that approved this study is the University of Southern California Health Sciences Institutional Review Board (committee reference number: not applicable).
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- Makhani M, Midani D, Goldberg A, Friedenberg FK. Pathogenesis and outcomes of traumatic injuries of the esophagus. Dis Esophagus. 2014;27:630–6.View ArticlePubMedGoogle Scholar
- Griffiths EA, Yap N, Poulter J, Hendrickse MT, Khurshid M. Thirty-four cases of esophageal perforation: the experience of a district general hospital in the UK. Dis Esophagus. 2009;22:616–25.View ArticlePubMedGoogle Scholar
- Vogel SB, Rout WR, Martin TD, Abbitt PL. Esophageal perforation in adults: aggressive, conservative treatment lowers morbidity and mortality. Ann Surg. 2005;241:1016–21.View ArticlePubMedPubMed CentralGoogle Scholar
- Onat S, Ulku R, Cigdem KM, Avci A, Ozcelik C. Factors affecting the outcome of surgically treated non-iatrogenic traumatic cervical esophageal perforation: 28-years’ experience at a single center. J Cardiothorac Surg. 2010;5:46.View ArticlePubMedPubMed CentralGoogle Scholar
- Attar S, Hankins JR, Suter CM, Coughlin TR, Sequeira A, McLaughlin JS. Esophageal perforation: a therapeutic challenge. Ann Thorac Surg. 1990;50:45–9.View ArticlePubMedGoogle Scholar
- Jones II WG, Ginsberg RJ. Esophageal perforation: a continuing challenge. Ann Thorac Surg. 1992;53:534–43.View ArticlePubMedGoogle Scholar
- Brinster CJ, Singhal S, Lee L, Marshall MB, Kaiser LR, Kucharczuk JC. Evolving options in the management of esophageal perforation. Ann Thorac Surg. 2004;77:1475–83.View ArticlePubMedGoogle Scholar
- Rubesin SE, Levine MS. Radiological diagnosis of gastrointestinal perforation. Radiol Clin North Am. 2003;41:1095–115.View ArticlePubMedGoogle Scholar
- Asensio JA, Chahwan S, Forno W, MacKersie R, Wall M, Lake J, et al. Penetrating esophageal injuries: multicenter study of the American Association for the Surgery of Trauma. J Trauma. 2001;50:289–96.View ArticlePubMedGoogle Scholar
- Patel MS, Malinoski DJ, Zhou L, Neal ML, Hoyt DB. Penetrating oesophageal injury: a contemporary analysis of the National Trauma Data Bank. Injury. 2013;44:48–55.View ArticlePubMedGoogle Scholar
- Biffl WL, Moore EE, Feliciano DV, Albrecht RA, Croce M, Karmy-Jones R, et al. Western Trauma Association critical decisions in trauma: diagnosis and management of esophageal injuries. J Trauma Acute Care Surg. 2015;79:1089–95.View ArticlePubMedGoogle Scholar
- Barrett N, Allison PR, Johnstone AS, Bonham-Carter RE. Discussion on unusual aspects of esophageal disease. Proc R Soc Med. 1956;49:529.PubMedGoogle Scholar
- Muir AD, White J, McGuigan JA, McManus KG, Graham AN. Treatment and outcomes of oesophageal perforation in a tertiary referral centre. Eur J Cardiothorac Surg. 2003;23:799–804.View ArticlePubMedGoogle Scholar
- Parsons S, Black E. Traumatic injury to the oesophagus. Surgery: Oesophagus and Stomach. 2006;24:101–4.Google Scholar
- Bhatia P, Fortin D, Inculet RI, Malthaner RA. Current concepts in the management of esophageal perforations: a twenty-seven year Canadian experience. Ann Thorac Surg. 2011;92:209–15.View ArticlePubMedGoogle Scholar
- Ivatury RR, Moore FA, Biffl W, Leppeniemi A, Ansaloni L, Catena F, et al. Oesophageal injuries: position paper, WSES, 2013. World J Emerg Surg. 2014;9(1):9.View ArticlePubMedPubMed CentralGoogle Scholar
- Markar SR, Mackenzie H, Wiggins T, Askari A, Faiz O, Zaninotto G, et al. Management and outcomes of esophageal perforation: a national study of 2,564 patients in England. Am J Gastroenterol. 2015;110:1559–66.View ArticlePubMedGoogle Scholar
- Dasari BV, Neely D, Kennedy A, Spence G, Rice P, Mackle E, et al. The role of esophageal stents in the management of esophageal anastomotic leaks and benign esophageal perforations. Ann Surg. 2014;259:852–60.View ArticlePubMedGoogle Scholar
- Biancari F, Saarnio J, Mennander A, Hypén L, Salminen P, Kuttila K, et al. Outcome of patients with esophageal perforations: a multicenter study. World J Surg. 2014;38:902–9.View ArticlePubMedGoogle Scholar
- Sudarshan M, Elharram M, Spicer J, Mulder D, Ferri LE. Management of esophageal perforation in the endoscopic era: is operative repair still relevant? Surgery. 2016;160:1104–10.View ArticlePubMedGoogle Scholar